Alk Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Alk
anaplastic lymphoma kinase
MGI:103305

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Alk^{tm1.1(ALKF1174L)Heno}/Alk⁺ Tg(Mpz-cre)94Imeg/0 Tg(Th-MYCN)41Waw/0 involves: 129X1/SvJ BALB/c * C57BL/6 * SJL	decreased tumor-free survival time	J:294092
	increased neuroblastoma incidence	J:294092
Alk^{tm1.1(ALKF1174L)Heno}/Alk^{tm1.1(ALKF1174L)Heno} involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL	no abnormal phenotype detected	J:294092
Alk^{tm1.1(ALKF1174L)Heno}/Alk^{tm1.1(ALKF1174L)Heno} Tg(Mpz-cre)94Imeg/0 involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL	abnormal sympathetic ganglion morphology	J:294092
	enlarged superior cervical ganglion	J:294092
	normal neoplasm	J:294092
Alk^{tm1.1(ALKF1174L)Heno}/Alk^{tm1.1(ALKF1174L)Heno} Tg(Mpz-cre)94Imeg/0 Tg(Th-MYCN)41Waw/0 involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL	decreased tumor latency	J:294092
	increased neuroblastoma incidence	J:294092
	premature death	J:294092
Alk^{tm1.1(ALKF1174L)Heno}/Alk^{tm1.1(ALKF1174L)Heno} Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺ involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL	abnormal stellate ganglion morphology	J:294092
	normal neoplasm	J:294092
Alk^tm1.1Ics/? Tg(Th-MYCN)41Waw/0 involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J	increased neuroblastoma incidence	J:228124, J:261033
	premature death	J:261033
Alk^tm1Swm/Alk^tm1Swm involves: 129P2/OlaHsd * C57BL/6J	normal behavior/neurological phenotype	J:227538
	enhanced behavioral response to alcohol	J:227538
	normal homeostasis/metabolism phenotype	J:227538
	increased alcohol consumption	J:227538
Alk^tm2.1Ics/? Tg(Th-MYCN)41Waw/0 involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J	increased neuroblastoma incidence	J:228124, J:261033
	premature death	J:261033

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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