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Gene Ontology Browser
Term Detail
GO term:transmembrane receptor protein tyrosine kinase signaling pathway
Synonym: transmembrane receptor protein tyrosine kinase signalling pathway
GO id:GO:0007169
Definition:A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-aleukemia inhibitory factor signaling pathway +
                                                                is-areceptor guanylyl cyclase signaling pathway
                                                                is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                        part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                        is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                        is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                        is-aephrin receptor signaling pathway +
                                                                        is-aERBB signaling pathway +
                                                                        is-afibroblast growth factor receptor signaling pathway +
                                                                        is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                        is-agrowth hormone receptor signaling pathway +
                                                                        is-ahepatocyte growth factor receptor signaling pathway +
                                                                        is-ainsulin receptor signaling pathway +
                                                                        is-ainsulin-like growth factor receptor signaling pathway +
                                                                        is-aKit signaling pathway +
                                                                        is-aneurotrophin TRK receptor signaling pathway +
                                                                        is-aplatelet-derived growth factor receptor signaling pathway +
                                                                        is-asevenless signaling pathway +
                                                                        is-aTie signaling pathway
                                                                        is-atorso signaling pathway
                                                                        is-avascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor signaling pathway +
                                                                is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-aleukemia inhibitory factor signaling pathway +
                                                        is-areceptor guanylyl cyclase signaling pathway
                                                        is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway +
                                                                is-avascular endothelial growth factor signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-aleukemia inhibitory factor signaling pathway +
                                                        is-areceptor guanylyl cyclase signaling pathway
                                                        is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway +
                                                                is-avascular endothelial growth factor signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-aleukemia inhibitory factor signaling pathway +
                                                                is-areceptor guanylyl cyclase signaling pathway
                                                                is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                        part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                        is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                        is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                        is-aephrin receptor signaling pathway +
                                                                        is-aERBB signaling pathway +
                                                                        is-afibroblast growth factor receptor signaling pathway +
                                                                        is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                        is-agrowth hormone receptor signaling pathway +
                                                                        is-ahepatocyte growth factor receptor signaling pathway +
                                                                        is-ainsulin receptor signaling pathway +
                                                                        is-ainsulin-like growth factor receptor signaling pathway +
                                                                        is-aKit signaling pathway +
                                                                        is-aneurotrophin TRK receptor signaling pathway +
                                                                        is-aplatelet-derived growth factor receptor signaling pathway +
                                                                        is-asevenless signaling pathway +
                                                                        is-aTie signaling pathway
                                                                        is-atorso signaling pathway
                                                                        is-avascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor signaling pathway +
                                                                is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-aleukemia inhibitory factor signaling pathway +
                                                        is-areceptor guanylyl cyclase signaling pathway
                                                        is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway +
                                                                is-avascular endothelial growth factor signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-aleukemia inhibitory factor signaling pathway +
                                                        is-areceptor guanylyl cyclase signaling pathway
                                                        is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway +
                                                                is-avascular endothelial growth factor signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-aleukemia inhibitory factor signaling pathway +
                                                        is-areceptor guanylyl cyclase signaling pathway
                                                        is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway +
                                                                is-avascular endothelial growth factor signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-aleukemia inhibitory factor signaling pathway +
                                                        is-areceptor guanylyl cyclase signaling pathway
                                                        is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                is-aephrin receptor signaling pathway +
                                                                is-aERBB signaling pathway +
                                                                is-afibroblast growth factor receptor signaling pathway +
                                                                is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                is-agrowth hormone receptor signaling pathway +
                                                                is-ahepatocyte growth factor receptor signaling pathway +
                                                                is-ainsulin receptor signaling pathway +
                                                                is-ainsulin-like growth factor receptor signaling pathway +
                                                                is-aKit signaling pathway +
                                                                is-aneurotrophin TRK receptor signaling pathway +
                                                                is-aplatelet-derived growth factor receptor signaling pathway +
                                                                is-asevenless signaling pathway +
                                                                is-aTie signaling pathway
                                                                is-atorso signaling pathway
                                                                is-avascular endothelial growth factor receptor signaling pathway +
                                                                is-avascular endothelial growth factor signaling pathway +
                                                        is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-aleukemia inhibitory factor signaling pathway +
                                                                is-areceptor guanylyl cyclase signaling pathway
                                                                is-atransmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] (461 genes, 770 annotations)
                                                                        part-ofactivation of transmembrane receptor protein tyrosine kinase activity
                                                                        is-abrain-derived neurotrophic factor receptor signaling pathway +
                                                                        is-acollagen-activated tyrosine kinase receptor signaling pathway
                                                                        is-aephrin receptor signaling pathway +
                                                                        is-aERBB signaling pathway +
                                                                        is-afibroblast growth factor receptor signaling pathway +
                                                                        is-aglial cell-derived neurotrophic factor receptor signaling pathway +
                                                                        is-agrowth hormone receptor signaling pathway +
                                                                        is-ahepatocyte growth factor receptor signaling pathway +
                                                                        is-ainsulin receptor signaling pathway +
                                                                        is-ainsulin-like growth factor receptor signaling pathway +
                                                                        is-aKit signaling pathway +
                                                                        is-aneurotrophin TRK receptor signaling pathway +
                                                                        is-aplatelet-derived growth factor receptor signaling pathway +
                                                                        is-asevenless signaling pathway +
                                                                        is-aTie signaling pathway
                                                                        is-atorso signaling pathway
                                                                        is-avascular endothelial growth factor receptor signaling pathway +
                                                                        is-avascular endothelial growth factor signaling pathway +
                                                                is-atransmembrane receptor protein tyrosine phosphatase signaling pathway


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory