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Allele Symbol Allele Name Allele ID |
Tnfrsf4tm2(cre)Nik targeted mutation 2, Nigel Killeen MGI:3843034 |
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| Summary |
13 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• absolute number of T reg cells in the spleen and the pancreatic lymph nodes are normal
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• development of diabetes is somewhat delayed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• memory T cell development is unaffected
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• impaired "reactivation" of T cells after a second antibody challenge
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• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure
• fewer cells in bronchoalveolar lavage fluid
• fewer eosinophiles
• increased number of macrophage
• reduced number of activated T cells after rechallenge (CD4+CD69+)
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| N |
• acute airway response to Ova challenge is unaffected
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• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure
• fewer cells in bronchoalveolar lavage fluid
• fewer eosinophiles
• increased number of macrophage
• reduced number of activated T cells after rechallenge (CD4+CD69+)
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• impaired "reactivation" of T cells after a second antibody challenge
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following immunization
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• following immunization
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• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
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• following immunization, the number of NP2-binding antibody forming cells in the bone marrow and spleen is reduced compared to in wild-type mice
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• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice
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• following immunization
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• following immunization
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• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
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• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• following immunization
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• 3-fold following immunization
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• following immunization, mice exhibit an increased in high-affinity antibody titers compared to in similarly treated wild-type mice
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• following immunization
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• 3-fold following immunization
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• following immunization, mice exhibit an increased in high-affinity antibody titers compared to in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
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• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
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• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
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• in an experimental autoimmune encephalomyelitis model
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• almost complete resistance
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
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• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
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• slight hyperplasia
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• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
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• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
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• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
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• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
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• in an experimental autoimmune encephalomyelitis model
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• slight hyperplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
|
|
• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
|
|
• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
|
|
• in an experimental autoimmune encephalomyelitis model
|
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• almost complete resistance
|
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
|
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• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
|
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• slight hyperplasia
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• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
|
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
|
|
• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
|
|
• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
|
|
• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
|
|
• in an experimental autoimmune encephalomyelitis model
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• slight hyperplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
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• in the thymus and spleen
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• in the lymph node
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• regulatory T cell turnover is impaired and suppressive function is lost
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• mild
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• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
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• in the thymus and spleen
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• in the lymph node
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• regulatory T cell turnover is impaired and suppressive function is lost
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• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice succumb to disease at 12-16 weeks of age
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• marker analysis indicates impaired keratinocyte differentiation
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• mice develop mild skin dermatitis
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• mice develop mild skin dermatitis
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• marker analysis indicates impaired keratinocyte differentiation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while the number of regulatory T cells is normal, they lack CD4 expression
• however, regulatory T cells are capable of suppressing T cell activity in vitro
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• while the number of regulatory T cells is normal, they lack CD4 expression
• however, regulatory T cells are capable of suppressing T cell activity in vitro
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
|
|
• in the thymus and spleen
|
|
• in the lymph node
|
|
• regulatory T cell turnover is impaired and suppressive function is lost
|
|
• mild
|
|
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
|
|
• in the thymus and spleen
|
|
• in the lymph node
|
|
• regulatory T cell turnover is impaired and suppressive function is lost
|
|
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• slightly under Th17-polarizing conditions
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• adoptive transfer of CD4+ Th17 cells immunized with MOG results in delayed onset and reduced severity of experimental autoimmune encephalomyelitis with reduced in recipient mice compared with when wild-type cells are transferred
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• slightly under Th17-polarizing conditions
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• slightly under Th17-polarizing conditions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop a wasting syndrome and succumb to disease by 11 weeks of age
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• mice develop an enlarged spleen
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• loss of hypodermal fat
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• marker analysis indicates impaired keratinocyte differentiation
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• mice with advanced disease show loss of skin barrier integrity at 7-8 weeks of age
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• mice develop severe, systemic dermatitis starting at 5 weeks of age
• inflammation is not seen in the lung, liver, kidney or gut
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• dermatitis is accompanied by hair loss
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• loss of hair follicles
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• mild epidermal hyperplasia and microabsceess are seen at 3 weeks of age but not at 10 days of age
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• skin contains epidermal scales
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• skin of mice with advanced disease contains lesions with epidermal damage, resulting in loss of skin barrier integrity
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• dermatitis is accompanied by skin thickening
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• increase in dermal fibrosis
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• mice develop an enlarged spleen
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• decrease in the frequency of Foxp3+ CD25+ Tregs with a corresponding increase in Foxp3-CD25+ effector T cells
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• CD4 T cells exhibit an activated phenotype
• mice develop systemic T helper type 2 immunity
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• mice develop peripheral lymphadenopathy
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• mice develop severe, systemic dermatitis starting at 5 weeks of age
• inflammation is not seen in the lung, liver, kidney or gut
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• mice with advanced disease show loss of skin barrier integrity at 7-8 weeks of age
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• mice develop an enlarged spleen
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• decrease in the frequency of Foxp3+ CD25+ Tregs with a corresponding increase in Foxp3-CD25+ effector T cells
|
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• CD4 T cells exhibit an activated phenotype
• mice develop systemic T helper type 2 immunity
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• marker analysis indicates impaired keratinocyte differentiation
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• loss of hypodermal fat
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in Th1-polarized T cells, IFN-gamma secretion is mildly, if at all, affected compared with similarly treated wild-type cells
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• Th2-polarized T cell exhibit impaired IL4 and IL5 secretion compared with similarly treated wild-type cells
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• slightly, but not significantly, in CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies
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• from anti-CD3- and anti-CD28-stimulated CD4+ T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
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• from anti-CD3- and anti-CD28-stimulated CD4+ T cells
• in Th2-polarized T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
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• in Th2-polarized T cells
• in the bronchoalveolar lavage fluid from ovalbumin challenged mice
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• following ovalbumin challenge, mice exhibit reduced inflammation (bronchoalveolar lavage total cell number, eosinophil infiltration, and levels of IL4, IL5, and IL13) compared with similarly treated wild-type mice
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• in Th1-polarized T cells, IFN-gamma secretion is mildly, if at all, affected compared with similarly treated wild-type cells
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• Th2-polarized T cell exhibit impaired IL4 and IL5 secretion compared with similarly treated wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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