Cd4^tm1Nik
Targeted Allele Detail

Summary

• Symbol: Cd4^tm1Nik
• Name: CD4 antigen; targeted mutation 1, Nigel Kileen
• MGI ID: MGI:2654930
• Synonyms: Cd4^lox
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^tm1Nik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73479
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted upstream of the initiator methionine codon in exon 2 and in intron 3. (J:73479)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 82 strains or lines available

References

• Original: J:73479 Wang Q, et al., Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. J Exp Med. 2001 Dec 17;194(12):1721-30
• All: 6 reference(s)