Analysis Tools
nervous system
| N |
• mice exhibit no change in Cajal-Retzius cell number
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Allele Symbol Allele Name Allele ID |
Tg(Nes-cre/ERT2)5-1Imayo transgene insertion 5-1, Itaru Imayoshi MGI:3641212 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit no change in Cajal-Retzius cell number
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following exposure to tamoxifen at E13.5, the late-born/upper-layer neurons in the cortical plate at P6.5 that had been labeled with BrdU at E19.0 is greater than in control Rnf2tm1Mvi homozygotes
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• following exposure to tamoxifen at E13.5, the late-born/upper-layer neurons in the cortical plate at P6.5 that had been labeled with BrdU at E19.0 is greater than in control Rnf2tm1Mvi homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following tamoxifen treatment at E13.5 and E14.5, the number of S100beta+ cells are reduced in the neocortex at P1.5 compared to in similarly treated control mice
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• following tamoxifen treatment at E13.5 and E14.5, the number of S100beta+ cells are reduced in the neocortex at P1.5 compared to in similarly treated control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
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• following treatment with tamoxifen, mice exhibit ablation of newly forming neurons
• following treatment with tamoxifen, neuroblasts at the entry site of the rostral migratory stream exhibit markers of apoptosis
• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
• following treatment with tamoxifen, mice exhibit a loss of granule cells in deep regions while superficial neurons are preserved
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• 3 weeks following treatment with tamoxifen, mice exhibit loss of granule neurons in the olfactory bulb
• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus compared to in wild-type mice
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| N |
• despite ablation of olfactory neurons, mice exhibit normal behavior towards wild-type mice and normal odor-associated memory
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• marked increase in Pax6+, Tbr2+ and Tuj1+ populations following tamoxifen administration at E9.5
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• telencephalic wall appears thinner following tamoxifen administration at E9.5
• telencephalic vesicles are remarkably dilated at E14.5, E16.5 and E18.5 following tamoxifen administration at E9.5
• volume of the ventral telencephalon is reduced and the wall of the dorsal telencephalon is thinner after E14.5 following tamoxifen administration at E9.5
• the ventricular surface area in the dorsolateral telencephalon (cortical region) is enlarged following tamoxifen administration at E9.5
• neuronal layer (Tuj1+) is thinner compared to controls following tamoxifen administration at E9.5
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• thickness of cortical neuronal layers is reduced at all stages following tamoxifen administration at E9.5
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• appears to be stretched in the tangential direction following tamoxifen administration at E9.5
• thinner following tamoxifen administration at E9.5
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• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5
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• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5
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• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5
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• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5
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• increase in the number of neuronal stem cells at E14.5 following tamoxifen administration at E9.5
• rapid depletion of neuronal stem cell pool between E14.5 and E16.5 following tamoxifen administration at E9.5
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• decrease in the number of Tbr2+ and early born neurons in cortical regions at E12.5 following tamoxifen administration at E9.5 indicating a delay in onset of neurogenesis
• proportional decrease in cortical neurons in all layers following tamoxifen administration at E9.5
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• at E12.5 neuronal stem cells continue to expand by symmetric divisions following tamoxifen administration at E9.5
• cell cycle length is reduced in the cortex at all stages examined following tamoxifen administration at E9.5
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• neuronal stem cell cell cycle length is reduced in the cortex at all stages examined following tamoxifen administration at E9.5
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• marked increase in Pax6+, Tbr2+ and Tuj1+ populations following tamoxifen administration at E9.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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