Hbp1^tm1.1Ohts
Targeted Allele Detail

Summary

• Symbol: Hbp1^tm1.1Ohts
• Name: high mobility group box transcription factor 1; targeted mutation 1.1, Toshiyuki Ohtsuka
• MGI ID: MGI:6361942
• Synonyms: Hbp1^flx
• Gene: Hbp1 Location: Chr12:31976449-32000529 bp, - strand Genetic Position: Chr12, 13.73 cM
• Alliance: Hbp1^tm1.1Ohts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278919
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1 and a loxP site and FRT flanked neo cassette were inserted in intron 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:278919)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hbp1 Mutation: 41 strains or lines available

References

• Original: J:278919 Watanabe N, et al., Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression. Development. 2015 Jul 1;142(13):2278-90
• All: 1 reference(s)