Phenotypes associated with this allele

• Allele Symbol: Hbp1^tm1.1Ohts
• Allele Name: targeted mutation 1.1, Toshiyuki Ohtsuka
• Allele ID: MGI:6361942
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hbp1^tm1.1Ohts/Hbp1^tm1.1Ohts Tg(Nes-cre/ERT2)5-1Imayo/0	involves: C57BL/6 * CBA/JNCrlj * ICR	MGI:6361945

Genotype
MGI:6361945

cn1

• Allelic Composition: Hbp1^tm1.1Ohts/Hbp1^tm1.1Ohts; Tg(Nes-cre/ERT2)5-1Imayo/0
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:278919 )

• marked increase in Pax6+, Tbr2+ and Tuj1+ populations following tamoxifen administration at E9.5

abnormal telencephalon morphology ( J:278919 )

• telencephalic wall appears thinner following tamoxifen administration at E9.5

• telencephalic vesicles are remarkably dilated at E14.5, E16.5 and E18.5 following tamoxifen administration at E9.5

• volume of the ventral telencephalon is reduced and the wall of the dorsal telencephalon is thinner after E14.5 following tamoxifen administration at E9.5

• the ventricular surface area in the dorsolateral telencephalon (cortical region) is enlarged following tamoxifen administration at E9.5

• neuronal layer (Tuj1+) is thinner compared to controls following tamoxifen administration at E9.5

abnormal telencephalon development ( J:278919 )

• thickness of cortical neuronal layers is reduced at all stages following tamoxifen administration at E9.5

abnormal cortical ventricular zone morphology ( J:278919 )

• appears to be stretched in the tangential direction following tamoxifen administration at E9.5

• thinner following tamoxifen administration at E9.5

decreased corpus callosum size ( J:278919 )

• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5

absent corpus callosum ( J:278919 )

• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5

hippocampus hypoplasia ( J:278919 )

• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5

absent hippocampus ( J:278919 )

• hypoplastic or absent at E18.5 following tamoxifen administration at E9.5

abnormal neuronal stem cell morphology ( J:278919 )

• increase in the number of neuronal stem cells at E14.5 following tamoxifen administration at E9.5

• rapid depletion of neuronal stem cell pool between E14.5 and E16.5 following tamoxifen administration at E9.5

decreased neuron number ( J:278919 )

• decrease in the number of Tbr2+ and early born neurons in cortical regions at E12.5 following tamoxifen administration at E9.5 indicating a delay in onset of neurogenesis

• proportional decrease in cortical neurons in all layers following tamoxifen administration at E9.5

increased neuronal stem cell self-renewal ( J:278919 )

• at E12.5 neuronal stem cells continue to expand by symmetric divisions following tamoxifen administration at E9.5

• cell cycle length is reduced in the cortex at all stages examined following tamoxifen administration at E9.5

cellular

abnormal cell cycle ( J:278919 )

• neuronal stem cell cell cycle length is reduced in the cortex at all stages examined following tamoxifen administration at E9.5

increased neuron apoptosis ( J:278919 )

• marked increase in Pax6+, Tbr2+ and Tuj1+ populations following tamoxifen administration at E9.5