Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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skeleton
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• a 5-fold increase in the rate of bone formation is detected; however, osteoblast surface and osteiod thickness are similar to wild-type
• in vitro osteoblasts produce larger and more mineralized nodules but show similar growth curve kinetics to wild-type cells
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• long bone marrow cavities are virtually obliterated by 7 months of age
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• bone mass is similar at birth but by 8 weeks of age bone mass is increased in the long bones, calvariae, and vertebrae
• however, no premature cartilage mineralization is seen and skeletal morphogenesis is similar to wild-type
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cellular
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• a 5-fold increase in the rate of bone formation is detected; however, osteoblast surface and osteiod thickness are similar to wild-type
• in vitro osteoblasts produce larger and more mineralized nodules but show similar growth curve kinetics to wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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immune system
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• CD4 cells activated in vitro by CD3/CD28 stimulation produce 10-fold less IL-2 than wild-type CD4 cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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Analysis of bone mass in Lrp5tm3.2Mawa/Lrp5tm3.2Mawa, Hivep3tm1Glm/Hivep3tm1Glm, and double mutant mice
skeleton
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• decreased trabecula spacing
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• increased bone formation rate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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skeleton
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• mesenchymal cells are defective in driving osteoclastogenesis
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• in whole-mount skull preparations and along the surfaces of increased diaphyseal trabecular bone
• however, numbers are normal just below the growth plate
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• due to aging and disuses
• however, bone loss due to secondary hyperparathyroidism is normal
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• increased diaphyseal trabecular bone
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cellular
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• mesenchymal cells are defective in driving osteoclastogenesis
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immune system
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• mesenchymal cells are defective in driving osteoclastogenesis
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• in whole-mount skull preparations and along the surfaces of increased diaphyseal trabecular bone
• however, numbers are normal just below the growth plate
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hematopoietic system
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• mesenchymal cells are defective in driving osteoclastogenesis
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• in whole-mount skull preparations and along the surfaces of increased diaphyseal trabecular bone
• however, numbers are normal just below the growth plate
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Allelic
Composition |
Hivep3tm1Glm/Hivep3+
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Genetic
Background |
involves: C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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Trabecular bone and clavicle analysis in various mice with Runx2tm1Mjo and/or Hivep3tm1Glm alleles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
Hivep3tm2Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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Bone phenotype in mice with various combiantions of Hivep3tm1Glm and/or Hivep3tm2Glm alleles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
Nfatc1tm3Glm mutation
(1 available);
any
Nfatc1 mutation
(47 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Tow mutation
(1 available);
any
Atf4 mutation
(21 available)
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
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Bone volume and trabeculae analysis in Hivep3tm1GlmHivep3tm1Glm and Atf4tm1Tow/Atf4tm1Tow Hivep3tm1Glm/Hivep3tm1Glm mice
skeleton
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• increased bone formation rate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
Lrp5tm3.2Mawa mutation
(0 available);
any
Lrp5 mutation
(81 available)
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Analysis of bone mass in Lrp5tm3.2Mawa/Lrp5tm3.2Mawa, Hivep3tm1Glm/Hivep3tm1Glm, and double mutant mice
skeleton
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• partially rescued from Hivep3tm1Glm homozygotes
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• partially rescued from Hivep3tm1Glm homozygotes
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• decreased trabecula spacing partially rescued from Hivep3tm1Glm homozygotes
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• partially rescued from Hivep3tm1Glm homozygotes
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• partially rescued from Hivep3tm1Glm homozygotes
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• osteosclerotic bone phenotype is partially rescued as in Hivep3tm1Glm homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
Runx2tm1Mjo mutation
(0 available);
any
Runx2 mutation
(42 available)
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Trabecular bone and clavicle analysis in various mice with Runx2tm1Mjo and/or Hivep3tm1Glm alleles
Analysis Tools