Hivep3^tm2Glm
Targeted Allele Detail

Summary

• Symbol: Hivep3^tm2Glm
• Name: human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 2, Laurie H Glimcher
• MGI ID: MGI:5550461
• Synonyms: Shn3^KI
• Gene: Hivep3 Location: Chr4:119590982-119992608 bp, + strand Genetic Position: Chr4, 55.51 cM, cytoband D1
• Alliance: Hivep3^tm2Glm page

Increase in femoral bone mass in Hivep3^tm2Glm/Hivep3^tm2Glm mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201597
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 4 was replaced with a modified exon in which nucleotide substitutions result in the amino acid substitution of three alanines for three lysines at positions 886, 887 and 888 (SHN3-KA) in the D-domain. (J:201597)

Schematic of the Hivep3^tm2Glm allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hivep3 Mutation: 103 strains or lines available

References

• Original: J:201597 Shim JH, et al., Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep 3;123(9):4010-22
• All: 2 reference(s)