Phenotypes associated with this allele

• Allele Symbol: Hivep3^tm2Glm
• Allele Name: targeted mutation 2, Laurie H Glimcher
• Allele ID: MGI:5550461
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hivep3^tm2Glm/Hivep3^tm2Glm	involves: C57BL/6	MGI:5550479
ht2	Hivep3^tm1Glm/Hivep3^tm2Glm	involves: C57BL/6	MGI:5550481

Genotype
MGI:5550479

hm1

• Allelic Composition: Hivep3^tm2Glm/Hivep3^tm2Glm
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increase in femoral bone mass in Hivep3^tm2Glm/Hivep3^tm2Glm mice

skeleton

skeleton phenotype ( J:201597 )

N • mice exhibit normal osteoclast numbers

abnormal osteoblast physiology ( J:201597 )

• osteoblasts exhibit increased mineralization compared with wild-type cells

increased bone volume ( J:201597 )

increased compact bone thickness ( J:201597 )

increased osteoblast cell number ( J:201597 )

increased bone trabecula number ( J:201597 )

increased bone mass ( J:201597 )

• progressive increase

cellular

abnormal osteoblast physiology ( J:201597 )

• osteoblasts exhibit increased mineralization compared with wild-type cells

Genotype
MGI:5550481

ht2

• Allelic Composition: Hivep3^tm1Glm/Hivep3^tm2Glm
• Genetic Background: involves: C57BL/6

Bone phenotype in mice with various combiantions of Hivep3^tm1Glm and/or Hivep3^tm2Glm alleles

skeleton

increased bone volume ( J:201597 )

increased compact bone thickness ( J:201597 )

increased bone trabecula number ( J:201597 )

increased trabecular bone thickness ( J:201597 )