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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Upk2-cre)6Xrw
transgene insertion 6, Xue-Ru Wu
MGI:3583893
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fgfr3tm4Cxd/Fgfr3+
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0 		involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N MGI:5141739
cn2
 		Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0 		involves: 129S4/SvJae * 129X1/SvJ * FVB/N MGI:5790500
cn3
 		Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Ptentm1Hwu/Ptentm1Hwu
Tg(Upk2-cre)6Xrw/0 		involves: 129S4/SvJae * 129X1/SvJ * FVB/N MGI:4943268
cn4
 		Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Upk2-cre)6Xrw/0 		involves: 129S4/SvJae * 129X1/SvJ * FVB/N MGI:4943270
cn5
 		Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0 		involves: 129S4/SvJae * 129X1/SvJ * FVB/N MGI:5141743
cn6
 		Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0 		involves: 129S4/SvJae * FVB/N MGI:5141740
cn7
 		Krastm4Tyj/Kras+
Ptentm1Hwu/Pten+
Tg(Upk2-cre)6Xrw/0 		involves: 129S4/SvJae * FVB/N MGI:5141742
cn8
 		Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0 		involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N MGI:5141741
cn9
 		Cdkn1atm1Led/Cdkn1atm1Led
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0 		involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N MGI:5790498
cn10
 		Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0 		involves: 129S6/SvEvTac * FVB/N MGI:5141738
cn11
 		Fgfr3tm1Iwa/Fgfr3+
Tg(Upk2-cre)6Xrw/0 		involves: 129S6/SvEvTac * FVB/N MGI:5141737
cn12
 		Cdkn1atm1Led/Cdkn1atm1Led
Tg(Upk2-cre)6Xrw/0 		involves: 129S6/SvEvTac * FVB/N MGI:5790499
cn13
 		Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0 		involves: 129X1/SvJ * FVB/N MGI:4943263
cn14
 		Ctnnb1tm1Mmt/Ctnnb1+
Tg(Upk2-cre)6Xrw/0 		involves: 129X1/SvJ * FVB/N MGI:4943264
cn15
 		Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
Tg(Upk2-HRAS*Q61L)5Xrw/0 		involves: 129X1/SvJ * FVB/N MGI:5790497


Genotype
MGI:5141739
cn1
Allelic
Composition		 Fgfr3tm4Cxd/Fgfr3+
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm4Cxd mutation (0 available); any Fgfr3 mutation (52 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased skin papilloma incidence ( J:174242 )
• by 1 year of age, 44% of mutants develop skin papilloma, with tumors reaching 1 cm in diameter by a median of 220 days

mortality/aging
premature death ( J:174242 )
• shorter survival due to skin papillomas, with a survival time between 100-400 days

neoplasm
neoplasm ( J:174242 )
N
• mice aged to 12 month do not develop urothelial hyperplasia or urothelial carcinoma or lung tumors
increased skin papilloma incidence ( J:174242 )
• by 1 year of age, 44% of mutants develop skin papilloma, with tumors reaching 1 cm in diameter by a median of 220 days




Genotype
MGI:5790500
cn2
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:234236 )
• mean survival of 185 days and median survival of 200 days

neoplasm
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop bladder tumors resembling urothelial cell carcinoma

renal/urinary system
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop bladder tumors resembling urothelial cell carcinoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
urinary bladder cancer DOID:11054 OMIM:109800
 J:234236




Genotype
MGI:4943268
cn3
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Ptentm1Hwu/Ptentm1Hwu
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
increased urinary bladder carcinoma incidence ( J:164579 )
• mice develop urothelial bladder tumors that progress to papillary carcinoma

renal/urinary system
increased urinary bladder carcinoma incidence ( J:164579 )
• mice develop urothelial bladder tumors that progress to papillary carcinoma




Genotype
MGI:4943270
cn4
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
increased urinary bladder carcinoma incidence ( J:164579 )
• mice develop urothelial bladder tumors that progress to papillary carcinoma

renal/urinary system
increased urinary bladder carcinoma incidence ( J:164579 )
• mice develop urothelial bladder tumors that progress to papillary carcinoma




Genotype
MGI:5141743
cn5
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm

respiratory system




Genotype
MGI:5141740
cn6
Allelic
Composition		 Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:174242 , J:234236 )
N
• mutants aged up to 18 months do not develop skin papillomas, bladder tumors or lung tumors (J:174242)
(J:234236)

renal/urinary system
renal/urinary system phenotype ( J:234236 )
N
• mice do not develop urothelium hyperplasia or bladder tumors




Genotype
MGI:5141742
cn7
Allelic
Composition		 Krastm4Tyj/Kras+
Ptentm1Hwu/Pten+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased skin papilloma incidence ( J:174242 )
• 42% of mutants develop skin papillomas

neoplasm
increased skin papilloma incidence ( J:174242 )
• 42% of mutants develop skin papillomas




Genotype
MGI:5141741
cn8
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Fgfr3tm4Cxd mutation (0 available); any Fgfr3 mutation (52 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:174242 )
• shorter survival due to lung cancer, with a survival time between 200-400 days

renal/urinary system
abnormal urinary bladder urothelium morphology ( J:174242 )
• 100% of mutants exhibit areas of hyperproliferation in the bladder urothelium from about 3 months of age, however these lesions do not progress further when examined at 12 months of age

neoplasm
neoplasm ( J:174242 )
N
• despite hyperproliferation in the bladder, mutants do not develop urothelial carcinoma by 12 months of age
• mutants do not develop skin papillomas
increased lung tumor incidence ( J:174242 )
• 36% of mutants develop lung tumors by 1 year of age
• lung tumors resemble solitary fibrous tumors of the lugs (hemangiopericytomas)

respiratory system
increased lung tumor incidence ( J:174242 )
• 36% of mutants develop lung tumors by 1 year of age
• lung tumors resemble solitary fibrous tumors of the lugs (hemangiopericytomas)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
 J:174242




Genotype
MGI:5790498
cn9
Allelic
Composition		 Cdkn1atm1Led/Cdkn1atm1Led
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (60 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:234236 )
• mean survival of 237 days and median survival of 238 days

neoplasm
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop urothelial cell carcinoma

renal/urinary system
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop urothelial cell carcinoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
urinary bladder cancer DOID:11054 OMIM:109800
 J:234236




Genotype
MGI:5141738
cn10
Allelic
Composition		 Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm4Cxd mutation (0 available); any Fgfr3 mutation (52 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:174242 )
N
• mutants do not develop skin or lung tumors, or urothelial hyperplasia, dysplasia or carcinoma




Genotype
MGI:5141737
cn11
Allelic
Composition		 Fgfr3tm1Iwa/Fgfr3+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm1Iwa mutation (0 available); any Fgfr3 mutation (52 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:174242 )
N
• mutants do not develop skin or lung tumors, or urothelial hyperplasia, dysplasia or carcinoma




Genotype
MGI:5790499
cn12
Allelic
Composition		 Cdkn1atm1Led/Cdkn1atm1Led
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (60 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:234236 )
N
• mice do not develop urothelial tumors or other urothelial abnormalities




Genotype
MGI:4943263
cn13
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal urinary bladder urothelium morphology ( J:164579 , J:234236 )
• mice develop hyperplastic lesions in the bladder unlike wild-type mice (J:164579)
• mice develop premalignant bladder lesions (J:234236)

neoplasm
neoplasm ( J:164579 )
N
• hyperproliferative lesions in the bladder do not progress to carcinoma




Genotype
MGI:4943264
cn14
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal urinary bladder urothelium morphology ( J:164579 , J:174242 )
• mice develop hyperplastic lesions in the bladder unlike wild-type mice (J:164579)
• 100% of mutants exhibit areas of hyperproliferation in the bladder urothelium from about 3 months of age, however these lesions do not progress further when examined at 12 months of age (J:174242)

neoplasm
neoplasm ( J:164579 , J:174242 )
N
• hyperproliferative lesions in the bladder do not progress to carcinoma (J:164579)
• mutants aged up to 18 months do not develop lung tumors, skin tumors or urothelial carcinoma (J:174242)




Genotype
MGI:5790497
cn15
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
Tg(Upk2-HRAS*Q61L)5Xrw/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
Tg(Upk2-HRAS*Q61L)5Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:234236 )
• mean survival of 231 days and median survival of 236 days

neoplasm
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop bladder tumors with progression to non-invasive papillary carcinomas (urothelial cell carcinoma)
• the number of proliferating cells within each tumor is increased compared to single conditional Ctnnb1tm1Mmt homozygotes
• mice treated with a MEK1/2 inhibitor, PD184352, show tumor regression and reduction in proliferation

renal/urinary system
hematuria ( J:234236 )
• due to bladder tumors
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop bladder tumors with progression to non-invasive papillary carcinomas (urothelial cell carcinoma)
• the number of proliferating cells within each tumor is increased compared to single conditional Ctnnb1tm1Mmt homozygotes
• mice treated with a MEK1/2 inhibitor, PD184352, show tumor regression and reduction in proliferation

homeostasis/metabolism
hematuria ( J:234236 )
• due to bladder tumors

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
urinary bladder cancer DOID:11054 OMIM:109800
 J:234236




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory