All Phenotypes Tg(Tyr-cre)1Lru MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Tyr-cre)1Lru
transgene insertion 1, Lionel Larue
MGI:3573939

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru/0	B6.Cg-Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru	MGI:6272341
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/0	B6.Cg-Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru Tg(Dct-lacZ)A12Jkn	MGI:6272344
cn3	Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0	B6.Cg-Pten^tm1Hwu Tg(Tyr-cre)1Lru	MGI:4882033
cn4	Ppargc1a^tm2Brsp/Ppargc1a^tm2Brsp Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk Tg(Tyr-cre)1Lru/0	involves: 129 * 129X1/SvJ * C57BL/6	MGI:6272349
cn5	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Bmpr2^tm1.1Enl/Bmpr2^tm1.1Enl Tg(Tyr-cre)1Lru/Y	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2	MGI:6258677
cn6	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Bmpr2^tm1.1Enl/Bmpr2^tm1.1Enl Tg(Tyr-cre)1Lru/0	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2	MGI:6258685
cn7	Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2	MGI:6220636
cn8	Fscn1^{Gt(OST124903)Lex}/Fscn1^{Gt(OST124903)Lex} Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Tyr-cre)1Lru/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:6209605
cn9	Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Tyr-cre)1Lru/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:6220632
cn10	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * CBA * DBA/2	MGI:6226060
cn11	Rest^tm1.1Yasu/Rest⁺ Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:6241517
cn12	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:6226058
cn13	Rest^tm1.1Yasu/Rest^tm1.1Yasu Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:6241524
cn14	Atg7^tm1Tchi/Atg7^tm1Tchi Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2	MGI:6209426
cn15	Chek1^tm1Jmr/Chek1⁺ Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * CBA * DBA/2	MGI:6220869
cn16	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * CBA * DBA/2	MGI:6220868
cn17	Nras^tm1Tyj/Nras⁺ Tg(Tyr-cre)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755101
cn18	Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755097
cn19	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * DBA/2	MGI:6220867

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru/0
Genetic Background	B6.Cg-Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanogenesis ( J:176245 )

• at 7 days of age, mice show absence of pigmentation in the hair follicle bulbs, unlike wild-type controls

reduced hair shaft melanin granule number ( J:176245 )

• spectrophotometry revealed absence of melanin in hairs, unlike in wild-type controls

abnormal pinna hair pigmentation ( J:176245 )

• mice exhibit white ears, similar to their coat pigmentation

abnormal tail hair pigmentation ( J:176245 )

• mice exhibit white tails, similar to their coat pigmentation

absent coat pigmentation ( J:176245 )

• mice exhibit a white coat color, unlike the black coat color of wild-type controls

integument

abnormal hair follicle melanogenesis ( J:176245 )

• at 7 days of age, mice show absence of pigmentation in the hair follicle bulbs, unlike wild-type controls

reduced hair shaft melanin granule number ( J:176245 )

• spectrophotometry revealed absence of melanin in hairs, unlike in wild-type controls

abnormal pinna hair pigmentation ( J:176245 )

• mice exhibit white ears, similar to their coat pigmentation

abnormal tail hair pigmentation ( J:176245 )

• mice exhibit white tails, similar to their coat pigmentation

absent coat pigmentation ( J:176245 )

• mice exhibit a white coat color, unlike the black coat color of wild-type controls

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/0
Genetic Background	B6.Cg-Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru Tg(Dct-lacZ)A12Jkn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Tg(Dct-lacZ)A12Jkn mutation (4 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased melanoblast proliferation ( J:176245 )

• overall, melanoblasts exhibit a much lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E14.5) relative to wild-type controls

• however, no differences in apoptosis, cell differentiation or fate are observed

abnormal melanoblast morphology ( J:176245 )

• in the trunk region, melanoblast number is normal at E10.5 but significantly lower than that in wild-type controls at each developmental stage from E12.5 to E15.5; this difference increases with time

• at E14.5, melanoblasts are less abundant than in mice hemizygous for the Tg(Tyr-Ctnnb1/EGFP)#Lru transgene, reflecting the differences in coat color observed after birth

• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis

cellular

decreased melanoblast proliferation ( J:176245 )

• overall, melanoblasts exhibit a much lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E14.5) relative to wild-type controls

• however, no differences in apoptosis, cell differentiation or fate are observed

nervous system

abnormal melanoblast morphology ( J:176245 )

• at E14.5, melanoblasts are less abundant than in mice hemizygous for the Tg(Tyr-Ctnnb1/EGFP)#Lru transgene, reflecting the differences in coat color observed after birth

• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0
Genetic Background	B6.Cg-Pten^tm1Hwu Tg(Tyr-cre)1Lru

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Smaller body size of Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0 (HM) mice at P20

mortality/aging

postnatal lethality, complete penetrance ( J:155110 )

• die between 13 and 20 days after birth

growth/size/body

slow postnatal weight gain ( J:155110 )

• although mutants are similar in weight and size as wild-type mice on P2, they fail to gain as much weight over the next 20 days as controls

digestive/alimentary system

abnormal intestine morphology ( J:155110 )

• mutants exhibit some intraluminal bubbles along the gastrointestinal tract

• mutants exhibit intestinal pseudoobstruction

distended cecum ( J:155110 )

• dilatation of the cecum

abnormal digestion ( J:155110 )

• mutants exhibit intestinal pseudoobstruction

nervous system

abnormal enteric nervous system morphology ( J:155110 )

• hypertrophy and hyperplasia of the myenteric and submucosal plexus in the enteric nervous system by 2 weeks of age resulting in ganglioneuromatosis

abnormal enteric ganglia morphology ( J:155110 )

• enteric ganglia are bigger than in wild-type at P15

abnormal enteric neuron morphology ( J:155110 )

• hyperplasia is observed in enteric neuronal cells at E17.5 while hypertrophy of enteric neuronal cells is only seen after birth and not during embryonic development

pigmentation

hyperpigmentation ( J:155110 )

• hyperpigmentation in the tail, pinna, paws, skin, and olfactory bulb

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
intestinal pseudo-obstruction		DOID:0080072		J:155110

Allelic Composition	Ppargc1a^tm2Brsp/Ppargc1a^tm2Brsp Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk Tg(Tyr-cre)1Lru/0
Genetic Background	involves: 129 * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1a^tm2Brsp mutation (0 available); any Ppargc1a mutation (47 available)
Ppargc1b^tm1Dpk mutation (1 available); any Ppargc1b mutation (56 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:194191 )

N	• on a C57BL/6 background, mice show no change in baseline coat color relative to control mice

Allelic Composition	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Bmpr2^tm1.1Enl/Bmpr2^tm1.1Enl Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2a^tm1Hsch mutation (0 available); any Acvr2a mutation (38 available)
Bmpr2^tm1.1Enl mutation (1 available); any Bmpr2 mutation (45 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:189569 )

• male pups show a dramatic hypopigmentation of the hair coat

abnormal hair follicle melanin granule morphology ( J:189569 )

• gray-haired skin shows normal melanocyte distribution but substantially less melanin in the hair follicles than control skin

• a reduction in melanin is noted in the hair bulb, where melanocytes form a conical cluster

reduced hair shaft melanin granule number ( J:189569 )

• a reduction in melanin is noted in the hair shaft

diluted coat color ( J:189569 )

• male pups develop uniformly gray coats; gray hair develops during the first period of hair production

small melanosome ( J:189569 )

• melanocytes of gray-haired skin produce numerous, dakly-pigmented miniaturized melanosomes, indicating impaired melanosome growth with no significant reduction in melanosome number or pigment-making ability

• failure of melanosomes to grow leads to less production/accumulation of melanin per melanosome

• miniaturized melanosomes are still transferred to epithelial cells of the hair shaft but hair shafts receive less pigment in total, resulting in hypopigmentation and gray color

integument

abnormal coat/hair pigmentation ( J:189569 )

• male pups show a dramatic hypopigmentation of the hair coat

abnormal hair follicle melanin granule morphology ( J:189569 )

• gray-haired skin shows normal melanocyte distribution but substantially less melanin in the hair follicles than control skin

• a reduction in melanin is noted in the hair bulb, where melanocytes form a conical cluster

reduced hair shaft melanin granule number ( J:189569 )

• a reduction in melanin is noted in the hair shaft

diluted coat color ( J:189569 )

• male pups develop uniformly gray coats; gray hair develops during the first period of hair production

Allelic Composition	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Bmpr2^tm1.1Enl/Bmpr2^tm1.1Enl Tg(Tyr-cre)1Lru/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

mosaic coat color ( J:189569 )

• female pups develop gray hair mosaically, consistent with the mosaic inactivation of the transgene-carrying X chromosome

integument

mosaic coat color ( J:189569 )

• female pups develop gray hair mosaically, consistent with the mosaic inactivation of the transgene-carrying X chromosome

Allelic Composition	Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dct-lacZ)A12Jkn mutation (4 available)
Tg(Tyr-cre)1Lru mutation (1 available)
Zeb2^tm1.1Yhi mutation (1 available); any Zeb2 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanocyte morphology ( J:211299 )

• at P5.5, mice show significantly fewer pigmented or LacZ+ hair follicles than control mice; also, completely undifferentiated hair follicles that are neither pigmented nor LacZ+ are observed, unlike in control mice

• at P5.5, the total number of melanocytes (S100b+) per hair follicle is reduced by 40% relative to that in control mice

• at P5.5, mice exhibit formation of undifferentiated melanocytes in the bulge area of hair follicles, along with loss of MITF (the master regulator of melanocyte development) and upregulation of ZEB1 expression

• the number of MITF+ melanocytes is strongly reduced relative to the total number of melanocytes per hair follicle (S100b+ melanocytes), whereas the number of PAX3+ melanocytes is normal; also, MITF protein levels are reduced in MITF+ cells

• most hair follicles are negative for terminal melanocyte differentiation markers, such as TYRP1 and tyrosinase enzymatic activity

• mRNA expression of several melanocyte differentiation markers (Tyrp1,Tyr, Dct, Pmel, Mc1R and Mitf) is significantly down-regulated in skin at E15.5

abnormal melanosome morphology ( J:211299 )

• at P5.5, a few remaining melanosomes are visible in some hair follicles; however, these melanosomes are spherical with irregular borders, unlike the rod-shaped melanosomes of control hair follicles

absent hair follicle melanin granules ( J:211299 )

• at P5.5, ZEB2-stained sections revealed absence of melanin in most melanocytes of the bulb area

reduced hair shaft melanin granule number ( J:211299 )

• at P5.5, ZEB2-stained sections revealed absence of melanin in the hair shafts

integument

abnormal hair follicle melanocyte morphology ( J:211299 )

• at P5.5, the total number of melanocytes (S100b+) per hair follicle is reduced by 40% relative to that in control mice

• most hair follicles are negative for terminal melanocyte differentiation markers, such as TYRP1 and tyrosinase enzymatic activity

• mRNA expression of several melanocyte differentiation markers (Tyrp1,Tyr, Dct, Pmel, Mc1R and Mitf) is significantly down-regulated in skin at E15.5

absent hair follicle melanin granules ( J:211299 )

• at P5.5, ZEB2-stained sections revealed absence of melanin in most melanocytes of the bulb area

reduced hair shaft melanin granule number ( J:211299 )

• at P5.5, ZEB2-stained sections revealed absence of melanin in the hair shafts

abnormal hair follicle bulge morphology ( J:211299 )

• mice show a reduction in LacZ+ melanocyte stem cells in the bulge area relative to control mice, consistent with fewer melanoblasts found in the epidermis

embryo

abnormal melanoblast migration ( J:211299 )

• at E15.5, the number of LacZ+ melanoblasts in the epidermis of both the belly and the back is significantly lower than that in control embryos; however, 30% of them reach the dorsal area (back) at E15.5

• at P5.5, some hair follicles are still LacZ+ and/or (hypo-)pigmented, indicating that melanoblasts can migrate and populate the bulb area of the hair follicles

• the number of melanoblasts present in the dermis at E15.5 is normal

abnormal melanoblast morphology ( J:211299 )

• at E15.5, the number of LacZ+ melanoblasts is significantly reduced in both dorsal and ventral areas relative to control embryos; melanoblast numbers are reduced more on the belly (95%) than on the back (70%), consistent with a migration defect

• at E15.5, melanoblasts exhibit less cell protrusions than control cells

nervous system

abnormal melanoblast morphology ( J:211299 )

• at E15.5, melanoblasts exhibit less cell protrusions than control cells

cellular

abnormal melanoblast migration ( J:211299 )

• at P5.5, some hair follicles are still LacZ+ and/or (hypo-)pigmented, indicating that melanoblasts can migrate and populate the bulb area of the hair follicles

• the number of melanoblasts present in the dermis at E15.5 is normal

Allelic Composition	Fscn1^{Gt(OST124903)Lex}/Fscn1^{Gt(OST124903)Lex} Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Tyr-cre)1Lru/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fscn1^{Gt(OST124903)Lex} mutation (1 available); any Fscn1 mutation (42 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal melanoblast migration ( J:197025 )

• melanoblasts in E14.5 skin explants show significantly reduced cell migration speed and euclidean distance travelled relative to wild-type controls

• ~30% of melanoblasts migrate with a speed slower than 0.5 um/minute versus fewer than 10% of melanoblasts in wild-type explants

• however, directionality (the ratio between the euclidean distance and total distance travelled) is normal

abnormal melanoblast morphology ( J:197025 )

• melanoblasts in E14.5 live skin explants are slightly smaller than wild type

• the rate of pseudopod generation in melanoblasts is modestly reduced but the lifetime of pseudopods is increased

• melanoblasts extend thinner protrusions with a smaller cross-sectional width than wild type controls

• thinner pseudopodia are less dynamic (longer-lived) leading to slower melanoblast migration

cellular

abnormal melanoblast migration ( J:197025 )

• melanoblasts in E14.5 skin explants show significantly reduced cell migration speed and euclidean distance travelled relative to wild-type controls

• ~30% of melanoblasts migrate with a speed slower than 0.5 um/minute versus fewer than 10% of melanoblasts in wild-type explants

• however, directionality (the ratio between the euclidean distance and total distance travelled) is normal

nervous system

abnormal melanoblast morphology ( J:197025 )

• melanoblasts in E14.5 live skin explants are slightly smaller than wild type

• the rate of pseudopod generation in melanoblasts is modestly reduced but the lifetime of pseudopods is increased

• melanoblasts extend thinner protrusions with a smaller cross-sectional width than wild type controls

• thinner pseudopodia are less dynamic (longer-lived) leading to slower melanoblast migration

Allelic Composition	Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-cre)1Lru mutation (1 available)
Zeb2^tm1.1Yhi mutation (1 available); any Zeb2 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

reduced hair shaft melanin granule number ( J:211299 )

• at 4-6 months of age, the melanin content of the dorsal and ventral hair shafts is reduced by 93% and 91%, respectively

• light microscopy confirmed the loss of melanin pigment from the hair shafts; however, hair with mixed pigmentation are also observed

hypopigmentation ( J:211299 )

• mice show severe congenital loss of hair pigmentation relative to control mice

• loss of hair pigmentation is evident from the first hair cycle and continues through adulthood

• however, eyes remain pigmented

integument

reduced hair shaft melanin granule number ( J:211299 )

• at 4-6 months of age, the melanin content of the dorsal and ventral hair shafts is reduced by 93% and 91%, respectively

• light microscopy confirmed the loss of melanin pigment from the hair shafts; however, hair with mixed pigmentation are also observed

Allelic Composition	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dct-lacZ)A12Jkn mutation (4 available)
Tg(Tyr-cre)1Lru mutation (1 available)
Yy1^tm2.1Yshi mutation (0 available); any Yy1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Absence of melanocytes or pigment in hair follicles of Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Tyr-cre)1Lru/Y Tg(Dct-lacZ)A12Jkn/0 mice at the anagen phase of the second hair cycle

pigmentation

abnormal hair follicle melanocyte morphology ( J:185128 )

• mice show absence of differentiated melanocytes in hair follicles at the anagen phase of the second hair cycle (P38)

absent hair follicle melanin granules ( J:185128 )

• mice show absence of pigment in hair follicles at the anagen phase of the second hair cycle (P38)

decreased melanocyte number ( J:185128 )

• absence of differentiated melanocytes in hair follicles at P38

integument

abnormal hair follicle melanocyte morphology ( J:185128 )

• mice show absence of differentiated melanocytes in hair follicles at the anagen phase of the second hair cycle (P38)

absent hair follicle melanin granules ( J:185128 )

• mice show absence of pigment in hair follicles at the anagen phase of the second hair cycle (P38)

embryo

abnormal melanoblast morphology ( J:185128 )

• absence of Dct-LacZ+ melanocyte stem cells (melanoblasts) in hair follicles at P38

nervous system

abnormal melanoblast morphology ( J:185128 )

• absence of Dct-LacZ+ melanocyte stem cells (melanoblasts) in hair follicles at P38

Allelic Composition	Rest^tm1.1Yasu/Rest⁺ Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rest^tm1.1Yasu mutation (1 available); any Rest mutation (95 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:230341 )

N	• mice never form white spots including on the belly region

Allelic Composition	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-cre)1Lru mutation (1 available)
Yy1^tm2.1Yshi mutation (0 available); any Yy1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Skin and hair pigmentation phenotype of Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Tyr-cre)1Lru/Y mice

pigmentation

abnormal coat/hair pigmentation ( J:185128 )

• mice exhibit premature gray hair after the first hair cycle

abnormal dorsoventral coat patterning ( J:185128 )

• during the first hair cycle (P0-P28), P10 ventral hairs are essentially devoid of pigment, whereas hairs from dorsal skin are much less pigmented than those in control mice; however, white dorsal fur is observed by P45

abnormal hair follicle melanocyte morphology ( J:185128 )

• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack DCT+ melanocytes, corresponding to subsequent white dorsal fur seen at P45

abnormal hair follicle melanin granule morphology ( J:185128 )

• at P4, dorsal skin shows small amounts of residual hair follicle melanin; residual dorsal melanocytes (DCT+) continue to express YY1, indicating incomplete Cre-mediated deletion

absent hair follicle melanin granules ( J:185128 )

• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack melanin pigment

decreased skin pigmentation ( J:185128 )

• at P4, mice show profoundly lighter skin pigmentation relative to control mice

decreased melanocyte number ( J:185128 )

• mice exhibit complete loss of hair follicle melanocytes after the first hair cycle

integument

abnormal coat/hair pigmentation ( J:185128 )

• mice exhibit premature gray hair after the first hair cycle

abnormal dorsoventral coat patterning ( J:185128 )

abnormal hair follicle melanocyte morphology ( J:185128 )

• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack DCT+ melanocytes, corresponding to subsequent white dorsal fur seen at P45

abnormal hair follicle melanin granule morphology ( J:185128 )

• at P4, dorsal skin shows small amounts of residual hair follicle melanin; residual dorsal melanocytes (DCT+) continue to express YY1, indicating incomplete Cre-mediated deletion

absent hair follicle melanin granules ( J:185128 )

• in the second hair cycle anagen phase (P28-P42), new dorsal hair follicles completely lack melanin pigment

decreased skin pigmentation ( J:185128 )

• at P4, mice show profoundly lighter skin pigmentation relative to control mice

Allelic Composition	Rest^tm1.1Yasu/Rest^tm1.1Yasu Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rest^tm1.1Yasu mutation (1 available); any Rest mutation (95 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:230341 )

N	• mice never form white spots including on the belly region

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanocyte proliferation ( J:220623 )

• cultured primary autophagy-deficient melanocytes stop proliferating after the third passage, unlike autophagy-competent melanocytes which can be maintained up to passage 5

abnormal coat/hair pigmentation ( J:220623 )

• mice show decreased pigmentation of dorsal hair; melanin content of dorsal hair is reduced by 10-15% relative to that in control mice

abnormal epidermal pigmentation ( J:220623 )

• mice exhibit slight hypopigmentation of the tail epidermis

abnormal epidermal melanocyte morphology ( J:220623 )

• some melanocytes of tail skin contain misshapen, swollen, and possibly disintegrating mitochondria, not observed in control melanocytes

• however, when cultured in vitro, primary autophagy-deficient melanocytes isolated from body skin of newborn mice show no significant change of melanin content relative to autophagy-competent melanocytes

decreased foot pigmentation ( J:220623 )

• pigmentation of the feet is decreased but to a lesser extent than in tail epidermis

decreased tail pigmentation ( J:220623 )

• at 9 months of age, pigmentation of tail skin is consistently lower than that of control mice

• melanocyte counts are consistently lower but not significantly decreased in the tail epidermis

abnormal melanosome morphology ( J:220623 )

• when cultured in vitro, primary autophagy-deficient melanocytes isolated from body skin of newborn mice show increased melanosome-associated vacuolation, unlike autophagy-competent melanocytes

• however, in vivo, both melanocytes and keratinocytes of tail skin contain mature melanosomes, suggesting normal melanosome formation, maturation, and transfer in the absence of an intact autophagy system

integument

abnormal coat/hair pigmentation ( J:220623 )

• mice show decreased pigmentation of dorsal hair; melanin content of dorsal hair is reduced by 10-15% relative to that in control mice

abnormal epidermal pigmentation ( J:220623 )

• mice exhibit slight hypopigmentation of the tail epidermis

abnormal epidermal melanocyte morphology ( J:220623 )

• some melanocytes of tail skin contain misshapen, swollen, and possibly disintegrating mitochondria, not observed in control melanocytes

decreased foot pigmentation ( J:220623 )

• pigmentation of the feet is decreased but to a lesser extent than in tail epidermis

decreased tail pigmentation ( J:220623 )

• at 9 months of age, pigmentation of tail skin is consistently lower than that of control mice

• melanocyte counts are consistently lower but not significantly decreased in the tail epidermis

cellular

dilated mitochondrion ( J:220623 )

• swollen mitochondria are observed in some melanocytes of tail skin, unlike in control mice

abnormal autophagy ( J:220623 )

• lipidation of microtubule-associated protein 1 light chain 3 beta (LC3), i.e. conversion of LC3-I to LC3-II, is completely blocked, indicating efficient disruption of autophagy in isolated melanocytes; in contrast, both LC3-I and LC3-II are detected in melanocytes of control mice

abnormal melanocyte proliferation ( J:220623 )

• cultured primary autophagy-deficient melanocytes stop proliferating after the third passage, unlike autophagy-competent melanocytes which can be maintained up to passage 5

early cellular replicative senescence ( J:220623 )

• in culture, primary autophagy-deficient melanocytes show a strong reduction in proliferative capacity and start acquiring senescent morphotypes with distended cytoplasms early in the second passage

• the premature senescent phenotype becomes even more prominent at the end of passage 2 and beginning of passage 3

oxidative stress ( J:220623 )

• autophagy-deficient melanocytes accumulate reactive oxygen species damage, ubiquitinated proteins, and the multi-functional adapter protein SQSTM1/p62

homeostasis/metabolism

abnormal autophagy ( J:220623 )

limbs/digits/tail

decreased tail pigmentation ( J:220623 )

• at 9 months of age, pigmentation of tail skin is consistently lower than that of control mice

• melanocyte counts are consistently lower but not significantly decreased in the tail epidermis

Allelic Composition	Chek1^tm1Jmr/Chek1⁺ Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: C57BL/6 * CBA * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm1Jmr mutation (1 available); any Chek1 mutation (41 available)
Tg(Dct-lacZ)A12Jkn mutation (4 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:265850 )

N	• despite a slight reduction of melanoblast numbers at E13.5, adult mice exhibit normal coat pigmentation relative to control mice

embryo

abnormal melanoblast morphology ( J:265850 )

• at E13.5, a slight but significant reduction of melanoblast numbers is noted in the head, dorsal, and ventral regions relative to control embryos

nervous system

abnormal melanoblast morphology ( J:265850 )

• at E13.5, a slight but significant reduction of melanoblast numbers is noted in the head, dorsal, and ventral regions relative to control embryos

Allelic Composition	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: C57BL/6 * CBA * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal melanoblast morphology ( J:265850 )

• significantly fewer beta-gal+ melanoblasts are noted in the head and trunk regions at E12.5, and by E13.5, melanoblasts are completely lost even from the pinna, vibrissae, and around the eyes

• many cleaved caspase 3+ melanoblasts are observed in the head and trunk regions, unlike in control embryos, suggesting increased melanoblast apoptosis

• however, the number and distribution of beta-gal+ melanoblasts is normal at E10.5 and E11.5

nervous system

abnormal melanoblast morphology ( J:265850 )

• significantly fewer beta-gal+ melanoblasts are noted in the head and trunk regions at E12.5, and by E13.5, melanoblasts are completely lost even from the pinna, vibrissae, and around the eyes

• many cleaved caspase 3+ melanoblasts are observed in the head and trunk regions, unlike in control embryos, suggesting increased melanoblast apoptosis

• however, the number and distribution of beta-gal+ melanoblasts is normal at E10.5 and E11.5

cellular

abnormal DNA replication ( J:265850 )

• many gamma-H2AX+ melanoblasts are noted in the head and trunk regions, unlike in control embryos, suggesting that aberrant DNA replication leads to spontaneous DNA damage and ultimately cell death

homeostasis/metabolism

abnormal DNA replication ( J:265850 )

Allelic Composition	Nras^tm1Tyj/Nras⁺ Tg(Tyr-cre)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:198244 )

• progress to akathisia and general malaise

hyperresponsive to tactile stimuli ( J:198244 )

• at a median age of 12.5 months

tremors ( J:198244 )

• seen at a median age of 12.5 months

impaired coordination ( J:198244 )

• mice exhibit incoordination at a median age of 12.5 months

abnormal gait ( J:198244 )

• mice show impaired gait at a median age of 12.5 months

skeleton

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

mortality/aging

premature death ( J:198244 )

• mice begin to die around 6 months of age with about 25% surviving past 18 months of age

craniofacial

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

pigmentation

hyperpigmentation ( J:198244 )

• darkening of the skin, tails, paws, and snouts that is evident from day 1 and persists throughout life, that is less pronounced than that in homozygotes

Allelic Composition	Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity

cellular

abnormal melanocyte proliferation ( J:198244 )

• increase in proliferation of leptomeningeal pigmented melanocytes

behavior/neurological

abnormal behavior ( J:198244 )

• symptoms progress rapidly to akathisia and general malaise

hyperresponsive to tactile stimuli ( J:198244 )

• at a median age of 4 months

tremors ( J:198244 )

• seen at a median age of 4 months

impaired coordination ( J:198244 )

• mice exhibit incoordination at a median age of 4 months

abnormal gait ( J:198244 )

• mice show impaired gait at a median age of 4 months

mortality/aging

premature death ( J:198244 )

• mice die before 12 months of age

craniofacial

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity

integument

abnormal skin morphology ( J:198244 )

• mice develop benign paucicellular dermal melanocytic lesions resembling human blue nevi

pigmentation

abnormal melanocyte proliferation ( J:198244 )

• increase in proliferation of leptomeningeal pigmented melanocytes

abnormal leptomeninges pigmentation ( J:198244 )

• brains show darkening of the leptomeninges that follows the sulci and fissures, and is more prominent in the frontoparietal region

• increase in the number of pigmented melanocytes that follow the gyri and sulci and envelop the ventricles (melanocytosis)

abnormal melanocyte morphology ( J:198244 )

• hyperpigmented dendritic melanocytes are seen in 3 week old and adult mice, particularly between the collagen bundles of the reticular dermis and along the adnexae of the deep dermal layers

hyperpigmentation ( J:198244 )

• darkening of the skin, tails, paws, and snouts that is evident from day 1 and persists throughout life

neoplasm

increased melanoma incidence ( J:198244 )

• darkly pigmented areas in the brain are composed of large melanocytic lesions comprising pleomorphic cells that invade the brain parenchyma with tumor cells rapidly dividing, indicating primary melanoma of the central nervous system

• however, mice do not develop cutaneous melanoma or tumors in the uvea, hearts, or oral and genital mucosa

• tumor cells frequently present intracytoplasmic melanin

Allelic Composition	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Tyr-cre)1Lru/Y
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm1Jmr mutation (1 available); any Chek1 mutation (41 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanocyte morphology ( J:265850 )

• no DCT-expressing melanocytes are observed in the hair follicles, unlike in control mice

absent coat pigmentation ( J:265850 )

• adult male mice are completely devoid of coat pigmentation, unlike control mice

abnormal epidermal melanocyte morphology ( J:265850 )

• male mice show complete lack of epidermal melanocytes

decreased melanocyte number ( J:265850 )

• adult males show a marked reduction or absence of neural crest-derived melanocytes in the eyes, unlike control mice

• however, males retain normal eye pigmentation in the retinal pigmented epithelium (RPE) due to inefficient transgene expression in the RPE

integument

abnormal hair follicle melanocyte morphology ( J:265850 )

• no DCT-expressing melanocytes are observed in the hair follicles, unlike in control mice

absent coat pigmentation ( J:265850 )

• adult male mice are completely devoid of coat pigmentation, unlike control mice

abnormal epidermal melanocyte morphology ( J:265850 )

• male mice show complete lack of epidermal melanocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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