Zeb2^tm1.1Yhi
Targeted Allele Detail

Summary

• Symbol: Zeb2^tm1.1Yhi
• Name: zinc finger E-box binding homeobox 2; targeted mutation 1.1, Yujiro Higashi
• MGI ID: MGI:2387499
• Synonyms: SIP1^flox(ex7), Sip1^loxP, Zeb2^fl, Zfhx1b^flox(ex7)
• Gene: Zeb2 Location: Chr2:44873644-45007407 bp, - strand Genetic Position: Chr2, 27.31 cM, cytoband C1
• Alliance: Zeb2^tm1.1Yhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75138
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Single loxP sites flank exon 7, which encodes several conserved domains. This allele was generated by excision of the floxed neo cassette from intron 6 of Zfhx1b^tm1Yhi via in vivo expression of cre recombinase. (J:75138)

Expression

In Mice Carrying this Mutation:	11 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zeb2 Mutation: 76 strains or lines available

References

• Original: J:75138 Higashi Y, et al., Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse. Genesis. 2002 Feb;32(2):82-4
• All: 53 reference(s)