All Phenotypes Mib1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mib1⁺
wild type
MGI:3048996

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apcdd1^em1Jlp/Apcdd1⁺ Asxl3^em1Jlp/Asxl3⁺ Mib1^em1Jlp/Mib1⁺	C57BL/6-Apcdd1^em1Jlp Asxl3^em1Jlp Mib1^em1Jlp	MGI:7544919
cx2	Bcl7a^em1Jlp/Bcl7a⁺ Cep192^em1Jlp/Cep192⁺ Mib1^em2Jlp/Mib1⁺ Tmx3^em1Jlp/Tmx3⁺	C57BL/6-Bcl7a^em1Jlp Cep192^em1Jlp Mib1^em2Jlp Tmx3^em1Jlp	MGI:7544923
cx3	Cep192^em1Jlp/Cep192⁺ Mib1^em2Jlp/Mib1⁺ Tmx3^em1Jlp/Tmx3⁺	C57BL/6-Cep192^em1Jlp Mib1^em2Jlp Tmx3^em1Jlp	MGI:7544921
cx4	Mib1^tm1Kong/Mib1⁺ Mib2^tm1Kong/Mib2^tm1Kong	involves: 129P2/OlaHsd * C57BL/6	MGI:3804811
cx5	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7544913
cx6	Mib1^em2Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7544912

Allelic Composition	Apcdd1^em1Jlp/Apcdd1⁺ Asxl3^em1Jlp/Asxl3⁺ Mib1^em1Jlp/Mib1⁺
Genetic Background	C57BL/6-Apcdd1^em1Jlp Asxl3^em1Jlp Mib1^em1Jlp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apcdd1^em1Jlp mutation (0 available); any Apcdd1 mutation (51 available)
Asxl3^em1Jlp mutation (0 available); any Asxl3 mutation (97 available)
Mib1^em1Jlp mutation (0 available); any Mib1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

thin ventricle myocardium compact layer ( J:338889 )

• in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

increased heart left ventricle weight ( J:338889 )

• in adults

dilated heart ( J:338889 )

• dilated atria and ventricles in adults

increased cardiac output ( J:338889 )

• elevated systolic and end diastolic volume in adults

muscle

thin ventricle myocardium compact layer ( J:338889 )

• in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

Allelic Composition	Bcl7a^em1Jlp/Bcl7a⁺ Cep192^em1Jlp/Cep192⁺ Mib1^em2Jlp/Mib1⁺ Tmx3^em1Jlp/Tmx3⁺
Genetic Background	C57BL/6-Bcl7a^em1Jlp Cep192^em1Jlp Mib1^em2Jlp Tmx3^em1Jlp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl7a^em1Jlp mutation (0 available); any Bcl7a mutation (29 available)
Cep192^em1Jlp mutation (0 available); any Cep192 mutation (75 available)
Mib1^em2Jlp mutation (0 available); any Mib1 mutation (55 available)
Tmx3^em1Jlp mutation (0 available); any Tmx3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal coronary artery morphology ( J:338889 )

• in E16.5 embryos

abnormal interventricular septum membranous part morphology ( J:338889 )

• in E16.5 embryos

abnormal interventricular septum muscular part morphology ( J:338889 )

• in E16.5 embryos

bicuspid aortic valve ( J:338889 )

• in E16.5 embryos

Allelic Composition	Cep192^em1Jlp/Cep192⁺ Mib1^em2Jlp/Mib1⁺ Tmx3^em1Jlp/Tmx3⁺
Genetic Background	C57BL/6-Cep192^em1Jlp Mib1^em2Jlp Tmx3^em1Jlp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep192^em1Jlp mutation (0 available); any Cep192 mutation (75 available)
Mib1^em2Jlp mutation (0 available); any Mib1 mutation (55 available)
Tmx3^em1Jlp mutation (0 available); any Tmx3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal coronary artery morphology ( J:338889 )

• in E16.5 embryos

abnormal interventricular septum membranous part morphology ( J:338889 )

• in E16.5 embryos

abnormal interventricular septum muscular part morphology ( J:338889 )

• in E16.5 embryos

bicuspid aortic valve ( J:338889 )

• in E16.5 embryos

Allelic Composition	Mib1^tm1Kong/Mib1⁺ Mib2^tm1Kong/Mib2^tm1Kong
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^tm1Kong mutation (0 available); any Mib1 mutation (55 available)
Mib2^tm1Kong mutation (0 available); any Mib2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:130369 )

• mice exhibit no abnormal phenotype

Allelic Composition	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^em1Jlp mutation (0 available); any Mib1 mutation (55 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:338889 )

N	• normal valve morphology in E16.5 embryos

Allelic Composition	Mib1^em2Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^em2Jlp mutation (0 available); any Mib1 mutation (55 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:338889 )

N	• normal ventricular morphology

abnormal aortic valve morphology ( J:338889 )

• in E16.5 embryos

bicuspid aortic valve ( J:338889 )

• in E16.5 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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