All Phenotypes Grhl3<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grhl3⁺
wild type
MGI:2655339

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Grhl3^{tm1a(EUCOMM)Wtsi}/Grhl3⁺	C57BL/6N-Grhl3^{tm1a(EUCOMM)Wtsi}/Ics	MGI:5782096
ht2	Grhl3^{tm2.1(F2rl1)Cgh}/Grhl3⁺	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)	MGI:5444859
ht3	Grhl3^tm1Jane/Grhl3⁺	involves: 129S1/Sv	MGI:5306662
ht4	Grhl3^ct/Grhl3⁺	involves: C57BL/6 * GFF	MGI:3794062
ht5	Grhl3^tm1Bogi/Grhl3⁺	involves: C57BL/6J	MGI:5697289
cn6	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL	MGI:4438090
cn7	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺ Rac1^tm1Djk/Rac1^tm1Djk	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:4438086
cn8	Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:4431052
cn9	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438085
cn10	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438084
cn11	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4431053
cx12	Grhl3^tm1Jane/Grhl3⁺ Pten^tm1Mak/Pten⁺	involves: 129P2/OlaHsd * 129S1/Sv	MGI:5306661
cx13	Grhl3^tm1(cre)Cgh/Grhl3⁺ Usp39^em1Imat/Usp39⁺	involves: 129P2/OlaHsd * CD-1	MGI:7287462
cx14	Grhl2^tm1.1Jane/Grhl2⁺ Grhl3^tm1Jane/Grhl3⁺	involves: 129S1/Sv * BALB/cJ * C57BL/6	MGI:4836386
cx15	Grhl2^tm1.1Jane/Grhl2^tm1.1Jane Grhl3^tm1Jane/Grhl3⁺	involves: 129S1/Sv * BALB/cJ * C57BL/6	MGI:4836389
cx16	Grhl3^tm1Bogi/Grhl3⁺ Irf6^{Gt(OST398253)Lex}/Irf6⁺	involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J	MGI:5697287
cx17	Axd/Axd⁺ Grhl3^ct/Grhl3⁺	involves: BALB/c * C3H/HeN * C57BL/6 * GFF	MGI:4948895

Allelic Composition	Grhl3^{tm1a(EUCOMM)Wtsi}/Grhl3⁺
Genetic Background	C57BL/6N-Grhl3^{tm1a(EUCOMM)Wtsi}/Ics
Cell Lines	EPD0039_3_C02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Grhl3 mutation (53 available)

Data Sources

IMPC Data for Grhl3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor activation ( J:165965 )

IMPC - ICS

hematopoietic system

decreased IgE level ( J:165965 )

IMPC - ICS

homeostasis/metabolism

decreased blood urea nitrogen level ( J:165965 )

IMPC - ICS

increased circulating glucose level ( J:165965 )

IMPC - ICS

decreased circulating triglyceride level ( J:165965 )

IMPC - ICS

increased circulating calcium level ( J:165965 )

IMPC - ICS

decreased circulating alkaline phosphatase level ( J:165965 )

IMPC - ICS

immune system

decreased IgE level ( J:165965 )

IMPC - ICS

vision/eye

abnormal eye morphology ( J:165965 )

IMPC - ICS

abnormal retina morphology ( J:165965 )

IMPC - ICS

Allelic Composition	Grhl3^{tm2.1(F2rl1)Cgh}/Grhl3⁺
Genetic Background	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^{tm2.1(F2rl1)Cgh} mutation (0 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

epidermal hyperplasia ( J:189278 )

• from two weeks onward

scaly skin ( J:189278 )

• although normal at birth, mice start to display scaly skin from 2 weeks onward

• most evident on the tail

skin lesions ( J:189278 )

• with occasional lymph node swelling

behavior/neurological

excessive scratching ( J:189278 )

• in adulthood but not in young mice

• not observed in mice without skin lesions and does not preceed the appearance of lesions

Allelic Composition	Grhl3^tm1Jane/Grhl3⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1Jane mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:178952 )

N	• mice are almost completely safe-guarded against skin squamous cell carcinoma formation

Allelic Composition	Grhl3^ct/Grhl3⁺
Genetic Background	involves: C57BL/6 * GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:24376 )

• 8 of 36 mice are affected

Allelic Composition	Grhl3^tm1Bogi/Grhl3⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1Bogi mutation (0 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial development ( J:226218 )

• bilateral epithelial abnormalities throughout the oral cavity and most frequently posterior to the tooth germs at E13.5, and include oral fusions (which have a loss of both the periderm and the basal epithelial layers)

• oral fusions occur between the mandible and either palate or the maxilla

• expression of p63 is reduced, indicating loss of basal epithelial cells at sites of the oral fusions

embryo

abnormal periderm development ( J:226218 )

• expression of Krt6, a marker for the periderm, is reduced, indicating loss or oral periderm cells

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13^tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:157446 )

• mutants die by 10.5 days post coitus (dpc)

embryo

abnormal embryo development ( J:157446 )

• embryos display turning defects and other defects, but the hindbrain neuropore is closed in mutants at 10.5 dpc

abnormal embryo turning ( J:157446 )

• embryos show turning defects

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺ Rac1^tm1Djk/Rac1^tm1Djk
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sor^tm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1095 available)
Rac1^tm1Djk mutation (1 available); any Rac1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:157446 )

• observed in about 58% of viable embryos collected at 14.5 days post coitus

• folate injections performed on pregnant females does not affect penetrance

nervous system

spina bifida ( J:157446 )

• observed in about 58% of viable embryos collected at 14.5 days post coitus

• folate injections performed on pregnant females does not affect penetrance

exencephaly ( J:157446 )

• observed with around 83% frequency in viable embryos collected at 14.5 days post coitus

• folate injections performed on pregnant females does not affect penetrance

Allelic Composition	Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna13^tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:157446 )

N	• embryos live through 14.5 days post coitus

nervous system

nervous system phenotype ( J:157446 )

N	• exencephaly is not observed in mutant embryos through E14.5

Allelic Composition	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaz^tm1Lfb mutation (1 available); any Gnaz mutation (15 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sor^tm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1095 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with around 4% frequency in viable embryos collected at 14.5 days post coitus

embryo

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

Allelic Composition	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

nervous system

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with 20% frequency at 14.5 days post coitus; no embryos

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube closure ( J:157446 )

• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen

nervous system

abnormal neural tube closure ( J:157446 )

• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen

exencephaly ( J:157446 )

• observed with 10% frequency in viable embryos collected at 14.5 days post coitus

Allelic Composition	Grhl3^tm1Jane/Grhl3⁺ Pten^tm1Mak/Pten⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1Jane mutation (1 available); any Grhl3 mutation (53 available)
Pten^tm1Mak mutation (1 available); any Pten mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

increased skin papilloma incidence ( J:178952 )

• in DMBA/TPA treated mice

increased skin squamous cell carcinoma incidence ( J:178952 )

• in DMBA/TPA treated mice to a greater extent than in either single heterozygote

neoplasm

increased skin papilloma incidence ( J:178952 )

• in DMBA/TPA treated mice

increased skin squamous cell carcinoma incidence ( J:178952 )

• in DMBA/TPA treated mice to a greater extent than in either single heterozygote

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3⁺ Usp39^em1Imat/Usp39⁺
Genetic Background	involves: 129P2/OlaHsd * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Usp39^em1Imat mutation (0 available); any Usp39 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair growth ( J:324183 )

• hair fails to grow on thickened scaly skin

scaly skin ( J:324183 )

• thickened scaly skin in some mice

thick skin ( J:324183 )

• thickened scaly skin in some mice

Allelic Composition	Grhl2^tm1.1Jane/Grhl2⁺ Grhl3^tm1Jane/Grhl3⁺
Genetic Background	involves: 129S1/Sv * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl2^tm1.1Jane mutation (2 available); any Grhl2 mutation (42 available)
Grhl3^tm1Jane mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:164805 )

• neural tube defects of varying severity are seen in 13 percent of embryos

exencephaly ( J:164805 )

• exencephaly involving only the mid- and hindbrain is seen in 5 percent of embryos

skeleton

abnormal vertebral pedicle morphology ( J:164805 )

• splayed vertebral pedicles are seen at the level of T11 in the most severely affected embryos

limbs/digits/tail

curly tail ( J:164805 )

• seen in a few embryos, either alone or in combination with spina bifida or exencephaly

embryo

abnormal neural tube morphology ( J:164805 )

• neural tube defects of varying severity are seen in 13 percent of embryos

Allelic Composition	Grhl2^tm1.1Jane/Grhl2^tm1.1Jane Grhl3^tm1Jane/Grhl3⁺
Genetic Background	involves: 129S1/Sv * BALB/cJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:164805 )

• fully penetrant thoraco-lumbo-sacral spina bifida

• a small region of the neural tube between the midthoracic region and the hindbrain/cervical cord boundary is closed

skeleton

cranioschisis ( J:164805 )

abnormal vertebral pedicle morphology ( J:164805 )

• splayed vertebral pedicles are seen at the level of T11 in the most severely affected embryos

craniofacial

cranioschisis ( J:164805 )

facial cleft ( J:164805 )

• failure of cranio-facial fusion at E10.5

embryo

spina bifida ( J:164805 )

• fully penetrant thoraco-lumbo-sacral spina bifida

• a small region of the neural tube between the midthoracic region and the hindbrain/cervical cord boundary is closed

growth/size/body

facial cleft ( J:164805 )

• failure of cranio-facial fusion at E10.5

Allelic Composition	Grhl3^tm1Bogi/Grhl3⁺ Irf6^{Gt(OST398253)Lex}/Irf6⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1Bogi mutation (0 available); any Grhl3 mutation (53 available)
Irf6^{Gt(OST398253)Lex} mutation (1 available); any Irf6 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:226218 )

• fewer than the expected numbers of mutants are seen at P21

prenatal lethality, incomplete penetrance ( J:226218 )

• 12% rate of resorbing embryos

craniofacial

abnormal craniofacial development ( J:226218 )

• oral adhesions at areas superficial to the tooth germ and oral adhesions (which have a loss of periderm) and fusions (which have a loss of both the periderm and the basal epithelial layers) posterior to the tooth germ

embryo

abnormal periderm development ( J:226218 )

• expression of Krt6, a marker for the periderm, is reduced more than in either single heterozygote, indicating loss of oral periderm cells

Allelic Composition	Axd/Axd⁺ Grhl3^ct/Grhl3⁺
Genetic Background	involves: BALB/c * C3H/HeN * C57BL/6 * GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axd mutation (1 available); any Axd mutation (1 available)
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:170759 )

• the frequency of curled tails is increased 2.5-fold compared to in Grhl3^ct heterozygotes

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