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Targeted Allele Detail
Symbol: Grhl3tm1(cre)Cgh
Name: grainyhead like transcription factor 3; targeted mutation 1, Shaun R Coughlin
MGI ID: MGI:4430902
Synonyms: Grhl3cre
Gene: Grhl3  Location: Chr4:135269199-135300941 bp, - strand  Genetic Position: Chr4, 67.76 cM
Alliance: Grhl3tm1(cre)Cgh page
Germline Transmission:  Earliest citation of germline transmission: J:157446
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Grhl3tm1(cre)Cgh expression driven by 1 gene
Mutation detailsExon 1 was disrupted by the insertion of a cassette containing a cre, IRES, nuclear localization signal, and lacZ in frame with the ATG start site. An frt flanked neomycin cassette was inserted following lacZ. Chimeric males were crossed with females expressing Flp recombinase on a C57BL/6 background in order to excise the neo selection cassette. (J:157446)
 Tissue activity of this recombinase allele
Driver: Grhl3 (mouse)
Summary of all recombinase alleles driven by Grhl3.

View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grhl3 Mutation:  53 strains or lines available
Original:  J:157446 Camerer E, et al., Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19;18(1):25-38
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory