Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fbxw7+ wild type MGI:2438793 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no living newborns are obtained, however normal ratios of E18.5 embryos are seen, indicating that mutants die around birth
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• alveolar septa are thickened at E18.5
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• increase in the number of proliferating cells (Ki67+) in the lung
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• aerated lung areas are small and alveolar septa are thickened at E18.5, suggesting respiratory failure as cause of perinatal lethality
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• 1.3% of mutants exhibit cleft palate
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• 1.3% of mutants exhibit cleft palate
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• 1.3% of mutants exhibit cleft palate
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• 17% of mutants exhibit eyes open at birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all pups die shortly after birth
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• disruption of the canalicular and /or terminal sac stage of lung development
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• thickened alveolar septa at E18.5
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• in 17 of 40 mice
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• in 30% of mice
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• in 30% of mice
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• in 30% of mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• bile duct hyperplasia is seen in some mice at 8 months of age
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• bile duct dilation is seen in some mice at 8 months of age
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• bile duct hyperplasia is seen in some mice at 8 months of age
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• bile duct dilation is seen in some mice at 8 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pIpC-treated mice infected with a retrovirus expression a truncated form of Notch1 that is constitutively cleaved in a ligand-independent manner or a Notch1 lacking the PEST domain exhibit shorted latency to development of leukemia
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| N |
• pIpC-treated mice exhibit normal numbers of hematopoietic stem cells and are more functionally competent than in cells from Fbxw7tm1Iaai/Fbxw7+ Tg(Mx1-cre)1Cgn mice
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| N |
• pIpC-treated mice exhibit normal numbers of early T cell progenitors in the thymus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not develop developmental defects
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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