Fbxw7^tm1Sje
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm1Sje
• Name: F-box and WD-40 domain protein 7; targeted mutation 1, Stephen Elledge
• MGI ID: MGI:3038749
• Synonyms: Fbw7^-
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm1Sje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88903
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and 6, which encode the F-box, were deleted via cre mediated recombination of loxP sites inserted in introns 4 and 6. An frt-flanked neo cassette remained in intron 4 after the excision of the floxed fragment. (J:88903)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 82 strains or lines available

References

• Original: J:88903 Tetzlaff MT, et al., Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3338-45
• All: 1 reference(s)