Analysis Tools
mortality/aging
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• embryos die around E10.5
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cardiovascular system
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• reduced vasculature in the embryos and in the yolk sac
• most evident in the capillary beds underlying the neural tube
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• normal looping morphogenesis followed by impaired chamber formation
• embryos do not form differentiated ventricles or atria but rather possess thickened looped tubes
• the abnormal hearts maintained contractility at E10.5
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embryo
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• at E9.5, gross underdevelopment of fore-, mid-, and hindbrain regions as well as incomplete neural tube closure
• mice do complete axial rotation and initiate branchial arch and anterior limb bud development successfully
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• approximately 60% the size of normal littermates
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• observed at E9.5 in many embryos
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pale yolk sac
(
J:88903
)
growth/size/body
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• at E9.5, gross underdevelopment of fore-, mid-, and hindbrain regions as well as incomplete neural tube closure
• mice do complete axial rotation and initiate branchial arch and anterior limb bud development successfully
|
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• approximately 60% the size of normal littermates
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hematopoietic system
nervous system
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• observed at E9.5 in many embryos
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• gross underdevelopment of fore-, mid-, and hindbrain regions at E9.5
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