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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp63+
wild type
MGI:2437307
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Trp63tm2Brd/Trp63+ B6.129S7-Trp63tm2Brd/J MGI:5140827
ht2
 		Trp63m1Mhda/Trp63+ C3HeB/FeJ-Trp63m1Mhda MGI:5702913
ht3
 		Trp63tm1Cmis/Trp63+ involves: 129P2/OlaHsd * C57BL/6 MGI:5468673
ht4
 		Trp63tm1Fmc/Trp63+ involves: 129S4/SvJae MGI:3695136
ht5
 		Trp63tm1Fmc/Trp63+ involves: 129S4/SvJae * C57BL/6 MGI:5289945
ht6
 		Trp63tm3Aam/Trp63+ involves: 129S7/SvEvBrd MGI:6477390
ht7
 		Trp63tm2Brd/Trp63+ involves: 129S7/SvEvBrd MGI:3798055
ht8
 		Trp63tm3.1Aam/Trp63+ involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477398
ht9
 		Trp63tm3.2Aam/Trp63+ involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477402
ht10
 		Trp63tm1.1(cre)Ssig/Trp63+ involves: 129S/SvEv * C57BL/6 MGI:5506938
ht11
 		Trp63tm1Aam/Trp63+ Not Specified MGI:3797857
ht12
 		Trp63tm2.2Elrf/Trp63+ Not Specified MGI:5576528
cx13
 		Trp53tm1Tyj/Trp53+
Trp63tm1Fmc/Trp63+ 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:5289961
cx14
 		Trp63tm1Fmc/Trp63+
Trp73tm1Fmc/Trp73+ 		involves: 129S4/SvJae * C57BL/6 MGI:5289956
cx15
 		Kdf1shd/Kdf1shd
Trp63tm2Brd/Trp63+ 		involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J MGI:5559506


Genotype
MGI:5140827
ht1
Allelic
Composition		 Trp63tm2Brd/Trp63+
Genetic
Background		 B6.129S7-Trp63tm2Brd/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2Brd mutation (1 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal horizontal basal cell of olfactory epithelium morphology ( J:173538 )
• at P0, fewer horizontal basal cells are present

respiratory system
abnormal horizontal basal cell of olfactory epithelium morphology ( J:173538 )
• at P0, fewer horizontal basal cells are present

craniofacial
abnormal horizontal basal cell of olfactory epithelium morphology ( J:173538 )
• at P0, fewer horizontal basal cells are present

growth/size/body
abnormal horizontal basal cell of olfactory epithelium morphology ( J:173538 )
• at P0, fewer horizontal basal cells are present




Genotype
MGI:5702913
ht2
Allelic
Composition		 Trp63m1Mhda/Trp63+
Genetic
Background		 C3HeB/FeJ-Trp63m1Mhda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63m1Mhda mutation (1 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82809 )
• mice heterozygous for this mutation are viable and exhibit no obvious abnormality




Genotype
MGI:5468673
ht3
Allelic
Composition		 Trp63tm1Cmis/Trp63+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Cmis mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

integument
abnormal epidermal layer morphology ( J:191121 )
• compromised desmosomes in the epidermis
abnormal keratinocyte physiology ( J:191121 )
• defects in cell-cell adhesion
• however, defects are alleviated by EGFR inhibition

craniofacial

digestive/alimentary system

growth/size/body
cleft palate ( J:191121 )




Genotype
MGI:3695136
ht4
Allelic
Composition		 Trp63tm1Fmc/Trp63+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Fmc mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female reproductive system morphology ( J:79340 )
• upper genital tract is slightly smaller but structurally identical to wild-type
small uterus ( J:79340 )
• slightly smaller but structurally identical to wild-type




Genotype
MGI:5289945
ht5
Allelic
Composition		 Trp63tm1Fmc/Trp63+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Fmc mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:98958 )
• half of heterozygous mutants are moribound by 14-15 months of age
• by 2 years of age, 32 of 40 mutants had to be sacrificed or died
• mice die from not only the malignant lesions but also from the benign lesions due to such things as obstructed airways from hyperplastic or premalignant lesions in the pharynx, larynx, mouth or tongue
premature aging ( J:98958 )
• 40% of mutants exhibit increased signs of aging, developing severe degenerative disc disease of the spine between 6 and 18 months of age

neoplasm
increased tumor incidence ( J:98958 )
• mutants show an increase in benign premalignant lesions such as squamous cell hyperplasia and multiple lung adenomas
• tumors undergo loss of heterozygosity
increased lung adenoma incidence ( J:98958 )
• frequency of lung adenomas is 2.5 times that seen in wild-type mice
increased histiocytic sarcoma incidence ( J:98958 )
• seen in 20% of mice by 12 months of age
increased squamous cell carcinoma incidence ( J:98958 )
• seen in 10% of mice by 12 months of age

skeleton
intervertebral disk degeneration ( J:98958 )
• 40% of mutants develop severe degenerative disc disease of the spine between 6 and 18 months of age
• degenerative disc disease is consistent with spondylosis and is most frequent in the cervical and thoracic region

respiratory system
increased lung adenoma incidence ( J:98958 )
• frequency of lung adenomas is 2.5 times that seen in wild-type mice




Genotype
MGI:6477390
ht6
Allelic
Composition		 Trp63tm3Aam/Trp63+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3Aam mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:294158 )
• fewer than the expected numbers of mice are seen at weaning with 18% lethality; lethality is apparent at birth

growth/size/body
abnormal tooth development ( J:294158 )
• defective tooth morphogenesis with abnormal root structures and hyperdontia
supernumerary teeth ( J:294158 )
abnormal tooth root morphology ( J:294158 )
• abnormal root structures
abnormal palatal shelf fusion at midline ( J:294158 )
• palatal shelves have not fused at E18.5
• adhesion and fusion of the secondary palate is stalled in a subset of E15 fetuses, appearing similar to palates of E13.5 wild-type mice
cleft palate ( J:294158 )
• severe cleft palate, with 15.4% of neonates exhibiting clefting

behavior/neurological
absent gastric milk in neonates ( J:294158 )
• newborns with cleft palate show absence of a milk pouch in the stomach

craniofacial
abnormal tooth development ( J:294158 )
• defective tooth morphogenesis with abnormal root structures and hyperdontia
abnormal tooth root morphology ( J:294158 )
• abnormal root structures
abnormal palatal shelf fusion at midline ( J:294158 )
• palatal shelves have not fused at E18.5
• adhesion and fusion of the secondary palate is stalled in a subset of E15 fetuses, appearing similar to palates of E13.5 wild-type mice
cleft palate ( J:294158 )
• severe cleft palate, with 15.4% of neonates exhibiting clefting

digestive/alimentary system
abnormal palatal shelf fusion at midline ( J:294158 )
• palatal shelves have not fused at E18.5
• adhesion and fusion of the secondary palate is stalled in a subset of E15 fetuses, appearing similar to palates of E13.5 wild-type mice
cleft palate ( J:294158 )
• severe cleft palate, with 15.4% of neonates exhibiting clefting

integument
alopecia ( J:294158 )
• mice exhibit alopecia with age
ruffled hair ( J:294158 )
• mice exhibit ruffled coat with age
nail dystrophy ( J:294158 )
• dystrophic nails
abnormal keratinocyte physiology ( J:294158 )
• primary keratinocytes exhibit reduced proliferation and a corresponding increase in cellular senescence
• however, no major skin abnormalities are seen at E16.5 or P0
decreased keratinocyte proliferation ( J:294158 )
• primary keratinocytes exhibit reduced proliferation

limbs/digits/tail
abnormal limb morphology ( J:294158 )
• anomalies of the distal limbs

skeleton
abnormal tooth development ( J:294158 )
• defective tooth morphogenesis with abnormal root structures and hyperdontia
abnormal tooth root morphology ( J:294158 )
• abnormal root structures

vision/eye
abnormal eye morphology ( J:294158 )
• mice exhibit eye squinting with age

cellular
decreased keratinocyte proliferation ( J:294158 )
• primary keratinocytes exhibit reduced proliferation




Genotype
MGI:3798055
ht7
Allelic
Composition		 Trp63tm2Brd/Trp63+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2Brd mutation (1 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:100483 )
• median life span is 95 weeks compared to 121 weeks for wild-type mice
• longevity is decreased 21.5% compared to wild-type mice
premature aging ( J:100483 )
• mice are euthanized due to age-related health issues (skin lesions or infections, weakness, palpable lymph nodes, enlarged abdomen, hemorrhage, rectal prolapse and aberrant circling behavior) earlier than wild-type mice

immune system
enlarged lymph nodes ( J:100483 )
• 19% of of euthanized mice exhibit palpable lymph nodes
kidney inflammation ( J:100483 )
• mice exhibit chronic nephritis
uterine cervix inflammation ( J:100483 )
• mice exhibit vaginal cervicitis
increased susceptibility to infection ( J:100483 )
• mice develop chronic infections if the skin, subcutaneous tissues, oropharynx and genitourinary tract

digestive/alimentary system
abnormal tongue epithelium morphology ( J:100483 )
• mice exhibit lesions in the epithelium of the tongue
• mice exhibit acanthosis of the tongue epithelia
abnormal rectum morphology ( J:100483 )
• mice exhibit lesions in the epithelium of the rectum
rectal prolapse ( J:100483 )
• 6% of euthanized mice exhibit rectal prolapse

cardiovascular system
hemorrhage ( J:100483 )
• 12% of euthanized mice exhibit visible signs of hemorrhage

reproductive system
uterine cervix inflammation ( J:100483 )
• mice exhibit vaginal cervicitis
abnormal uterine cervix epithelium morphology ( J:100483 )
• mice exhibit lesions in the epithelium of the cervix

renal/urinary system
kidney inflammation ( J:100483 )
• mice exhibit chronic nephritis

growth/size/body
abnormal tongue epithelium morphology ( J:100483 )
• mice exhibit lesions in the epithelium of the tongue
• mice exhibit acanthosis of the tongue epithelia
distended abdomen ( J:100483 )
• 14% of euthanized mice exhibit enlarged abdomen

behavior/neurological
weakness ( J:100483 )
• 35% of euthanized mice exhibit extreme weakness
circling ( J:100483 )
• 2% of euthanized mice exhibit aberrant circling

vision/eye
abnormal cornea epithelium morphology ( J:100483 )
• mice exhibit lesions in the epithelium of the cornea of the eye
• mice exhibit corneal granulation

craniofacial
abnormal tongue epithelium morphology ( J:100483 )
• mice exhibit lesions in the epithelium of the tongue
• mice exhibit acanthosis of the tongue epithelia

integument
alopecia ( J:100483 )
• mice exhibit moderate alopecia
acanthosis ( J:100483 )
• mice exhibit acanthosis of the tongue epithelia
skin lesions ( J:100483 )
• 52% of euthanized mice exhibit skin lesions or infections mice exhibit hyperplastic epithelila and progressive skin lesions
spontaneous skin ulceration ( J:100483 )
• mice exhibit ulcerations with severe abscesses in the dermis that often contain bacterial inclusions




Genotype
MGI:6477398
ht8
Allelic
Composition		 Trp63tm3.1Aam/Trp63+
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3.1Aam mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 2.3% of neonates exhibit cleft palate

cellular
decreased keratinocyte proliferation ( J:294158 )
• primary keratinocytes exhibit reduced proliferation

digestive/alimentary system
cleft palate ( J:294158 )
• 2.3% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 2.3% of neonates exhibit cleft palate

integument
abnormal keratinocyte physiology ( J:294158 )
• primary keratinocytes exhibit reduced proliferation and a corresponding increases in cellular senescence
• however, no major skin abnormalities are seen at E16.5 or P0
decreased keratinocyte proliferation ( J:294158 )
• primary keratinocytes exhibit reduced proliferation




Genotype
MGI:6477402
ht9
Allelic
Composition		 Trp63tm3.2Aam/Trp63+
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3.2Aam mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:294158 )
• approximate 8% lethality in weanlings, affecting only males

craniofacial
craniofacial phenotype ( J:294158 )
N
• cleft palate is not detected in neonates




Genotype
MGI:5506938
ht10
Allelic
Composition		 Trp63tm1.1(cre)Ssig/Trp63+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1.1(cre)Ssig mutation (1 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:197339 )
• mice show no gross or microscopic phenotypic abnormalities and are fertile




Genotype
MGI:3797857
ht11
Allelic
Composition		 Trp63tm1Aam/Trp63+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Aam mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal phalanx morphology ( J:135784 )
• one mouse exhibits mild deviation of the central phalanges
ectrodactyly ( J:135784 )
• only observed in 1 of 40 mice
• mild ectodactyly is rare

skeleton
abnormal phalanx morphology ( J:135784 )
• one mouse exhibits mild deviation of the central phalanges




Genotype
MGI:5576528
ht12
Allelic
Composition		 Trp63tm2.2Elrf/Trp63+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.2Elrf mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal epidermis stratum basale morphology ( J:206433 )
• expanded epidermal basal layer
wrinkled skin ( J:206433 )
• excess folds of skin




Genotype
MGI:5289961
cx13
Allelic
Composition		 Trp53tm1Tyj/Trp53+
Trp63tm1Fmc/Trp63+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
Trp63tm1Fmc mutation (0 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:98958 )
• median age of survival is 7 months
premature aging ( J:98958 )
• 40% of mutants exhibit increased signs of aging, developing severe degenerative disc disease of the spine between 6 and 18 months of age

neoplasm
increased metastatic potential ( J:98958 )
• about 50% of mutants develop metastatic tumors
increased tumor incidence ( J:98958 )
• mutants exhibit an increase in tumor burden compared to heterozygous Trp53 mice, with 90% of mutant mice having multiple tumors of the same or distinct types compared to only 10% in Trp53 heterozygotes
• mutants develop collision tumors composed of mammary adenocarcinomas directly adjacent to squamous cell carcinomas and/or rhabdomyosarcomas
• tumors exhibit loss of heterozygosity of one or both genes
increased T cell derived lymphoma incidence ( J:98958 )
• 10% of mutants develop thymic lymphomas
increased mammary adenocarcinoma incidence ( J:98958 )
• 10% of mutants develop mammary adenocarcinomas
increased rhabdomyosarcoma incidence ( J:98958 )
• 20% of mutants develop rhabdomyosarcomas
increased chronic myelocytic leukemia incidence ( J:98958 )
• 15% of mutants develop myelogenous leukemia
increased squamous cell carcinoma incidence ( J:98958 )
• 50% of mutants develop squamous cell carcinomas in multiple tissues (larynx, pharynx, cervix, and esophagus)
increased urinary bladder transitional cell carcinoma incidence ( J:98958 )
• 20% of mutants develop transitional cell carcinoma of the bladder
increased osteosarcoma incidence ( J:98958 )
• 20% of mutants develop osteosarcomas

skeleton
increased osteosarcoma incidence ( J:98958 )
• 20% of mutants develop osteosarcomas
intervertebral disk degeneration ( J:98958 )
• 40% of mutants develop severe degenerative disc disease of the spine between 6 and 18 months of age
• degenerative disc disease is consistent with spondylosis and is most frequent in the cervical and thoracic region

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:98958 )
• 10% of mutants develop thymic lymphomas
increased mammary adenocarcinoma incidence ( J:98958 )
• 10% of mutants develop mammary adenocarcinomas

integument
increased mammary adenocarcinoma incidence ( J:98958 )
• 10% of mutants develop mammary adenocarcinomas

muscle
increased rhabdomyosarcoma incidence ( J:98958 )
• 20% of mutants develop rhabdomyosarcomas

renal/urinary system
increased urinary bladder transitional cell carcinoma incidence ( J:98958 )
• 20% of mutants develop transitional cell carcinoma of the bladder

hematopoietic system
increased T cell derived lymphoma incidence ( J:98958 )
• 10% of mutants develop thymic lymphomas

immune system
increased T cell derived lymphoma incidence ( J:98958 )
• 10% of mutants develop thymic lymphomas




Genotype
MGI:5289956
cx14
Allelic
Composition		 Trp63tm1Fmc/Trp63+
Trp73tm1Fmc/Trp73+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Fmc mutation (0 available); any Trp63 mutation (59 available)
Trp73tm1Fmc mutation (0 available); any Trp73 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:98958 )
• mutants survive for a shorter period of time than either single mutant, with some mutants dying by 6 months of age
premature aging ( J:98958 )
• 60% of mutants exhibit increased signs of aging, developing severe degenerative disc disease of the spine between 6 and 18 months of age

neoplasm
increased metastatic potential ( J:98958 )
• about 30% of mutants develop metastatic tumors
increased tumor incidence ( J:98958 )
• tumors undergo loss of heterozygosity
• 50% of mutant mice have multiple tumors of the same or distinct types
increased T cell derived lymphoma incidence ( J:98958 )
• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia
increased chronic myelocytic leukemia incidence ( J:98958 )
• mutants that die by 6 months of age develop myelogenous leukemia, thymic lymphoma, or hemangiosarcoma
increased carcinoma incidence ( J:98958 )
• mice that die between 6 and 12 months of age most frequently develop carcinomas
increased hemangiosarcoma incidence ( J:98958 )
• mutants that die by 6 months of age develop hemangiosarcoma, myelogenous leukemia, or thymic lymphoma

skeleton
intervertebral disk degeneration ( J:98958 )
• 60% of mutants develop severe degenerative disc disease of the spine between 6 and 18 months of age
• degenerative disc disease is consistent with spondylosis and is most frequent in the cervical and thoracic region

behavior/neurological
paralysis ( J:98958 )
• in 10% of mutants, degenerative disc disease is so severe, it results in partial paralysis

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:98958 )
• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia

respiratory system

integument

digestive/alimentary system

hematopoietic system
increased T cell derived lymphoma incidence ( J:98958 )
• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia

immune system
increased T cell derived lymphoma incidence ( J:98958 )
• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia

craniofacial

growth/size/body
increased salivary gland adenoma incidence ( J:98958 )
• salivary adenoma




Genotype
MGI:5559506
cx15
Allelic
Composition		 Kdf1shd/Kdf1shd
Trp63tm2Brd/Trp63+
Genetic
Background		 involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdf1shd mutation (0 available); any Kdf1 mutation (17 available)
Trp63tm2Brd mutation (1 available); any Trp63 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:203995 )
N
• epidermal barrier formation, increased basal keratinocyte proliferation, lateral epidermis thickness and impaired keratinocyte differentiation defects observed in 1810019J16Rikshd homozygotes are rescued

limbs/digits/tail
limbs/digits/tail phenotype ( J:203995 )
N
• limb protrusion defects and tail-hindlimb fusion observed in 1810019J16Rikshd homozygotes homozygotes is rescued




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory