Trp63^{tm1.1(cre)Ssig}
Targeted Allele Detail

Summary

• Symbol: Trp63^{tm1.1(cre)Ssig}
• Name: transformation related protein 63; targeted mutation 1,1, Sabina Signoretti
• MGI ID: MGI:5502576
• Synonyms: deltaNp63^Cre
• Gene: Trp63 Location: Chr16:25502513-25710838 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^{tm1.1(cre)Ssig} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Trp63^{tm1.1(cre)Ssig} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trp63 (MGI:1330810)

• Mutation details: A targeting vector was constructed with cre cDNA and an frt-flanked neomycin selection cassette flanked by Trp63 homology arms. The linearized vector was electroporated into ES cells for homologous recombination. This resulted in insertion of the ATG start codon of the cre sequence into the Trp63 locus, replacing the endogenous ATG. (J:197339)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trp63 (mouse) Summary of all recombinase alleles driven by Trp63. Alliance mouse Trp63 gene page

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:197339 Pignon JC, et al., p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8105-10
• All: 4 reference(s)