Phenotypes associated with this allele

• Allele Symbol: Trp63^{tm1.1(cre)Ssig}
• Allele Name: targeted mutation 1,1, Sabina Signoretti
• Allele ID: MGI:5502576
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp63^tm1.1(cre)Ssig/Trp63^tm1.1(cre)Ssig	involves: 129S/SvEv * C57BL/6	MGI:5506939
ht2	Trp63^tm1.1(cre)Ssig/Trp63^+	involves: 129S/SvEv * C57BL/6	MGI:5506938

Genotype
MGI:5506939

hm1

• Allelic Composition: Trp63^{tm1.1(cre)Ssig}/Trp63^{tm1.1(cre)Ssig}
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:197339 )

• homozygotes display phenotypes identical to described Trp63-null alterations

limbs/digits/tail

decreased limb number ( J:197339 )

• homozygotes display phenotypes identical to described Trp63-null alterations

digestive/alimentary system

abnormal esophageal epithelium morphology ( J:197339 )

• esophagus is lined by a pseudostratified epithelium consisting of cuboidal and columnar cells

integument

absent epidermis ( J:197339 )

• skin lacks an epidermis in embryos examined at E17.5

Genotype
MGI:5506938

ht2

• Allelic Composition: Trp63^{tm1.1(cre)Ssig}/Trp63⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:197339 )

• mice show no gross or microscopic phenotypic abnormalities and are fertile