All Phenotypes Scgb1a1<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scgb1a1^tm1Abm/Scgb1a1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:6313624
ht2	Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S4/SvJaeSor * 129S6/SvEv * C57BL/6	MGI:3850367
cn3	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4839215
cn4	Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4839214
cn5	Kras^tm4Tyj/Kras⁺ Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4839216
cn6	Kras^tm4Tyj/Kras⁺ Scgb1a1^tm1(cre)Fjd/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:8226383
cn7	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:8226385
cn8	Foxp1^tm1.1Pwt/Foxp1^tm1.1Pwt Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Scgb1a1^tm1(icre)Fjd/Scgb1a1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5433107
cn9	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺ Trp53^tm5Tyj/Trp53⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5317170
cn10	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S6/SvEv * C57BL/6	MGI:4820811
cn11	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S6/SvEv * C57BL/6	MGI:4820809

Allelic Composition	Scgb1a1^tm1Abm/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scgb1a1^tm1Abm mutation (0 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased IgA level ( J:57504 )

• mice exhibit moderate glomerular deposition of IgA

homeostasis/metabolism

abnormal complement protein level ( J:57504 )

• mice exhibit abnormal renal glomerular deposition of complement C3

immune system

increased IgA level ( J:57504 )

• mice exhibit moderate glomerular deposition of IgA

abnormal complement protein level ( J:57504 )

• mice exhibit abnormal renal glomerular deposition of complement C3

renal/urinary system

abnormal renal glomerulus morphology ( J:57504 )

• mice exhibit moderate glomerular deposition of IgA and deposition of complement C3

• glomeruli exhibit an abnormal deposition of an eosinophilic material which includes fibronectin and collagen

Allelic Composition	Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scgb1a1^{tm1(cre/ERT)Blh} mutation (1 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:149822 )

• mice are viable and fertile

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Scgb1a1^{tm1.1(cre)Fjd} mutation (0 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:131721 )

• average survival is 24 weeks

respiratory system

abnormal lung morphology ( J:131721 )

• mutants develop lung lesions that are first detected at 12 weeks of age in alveoli and bronchioles

• mutants develop epithelial lesions termed atypical papillary bronchiolar proliferation that has papillary proliferations of the bronchiolar epithelium located at the bronchiolar terminal site

• however, no carcinomas are seen by 24 weeks of age

increased lung tumor incidence ( J:131721 )

• mutants develop lung lesions that are first detected at 12 weeks of age in alveoli and bronchioles

• mutants develop epithelial lesions termed atypical papillary bronchiolar proliferation that has papillary proliferations of the bronchiolar epithelium located at the bronchiolar terminal site

increased lung adenoma incidence ( J:131721 )

• atypical adenomatous hyperplasia lesions and adenomas

neoplasm

increased lung tumor incidence ( J:131721 )

• mutants develop lung lesions that are first detected at 12 weeks of age in alveoli and bronchioles

• mutants develop epithelial lesions termed atypical papillary bronchiolar proliferation that has papillary proliferations of the bronchiolar epithelium located at the bronchiolar terminal site

increased lung adenoma incidence ( J:131721 )

• atypical adenomatous hyperplasia lesions and adenomas

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Scgb1a1^{tm1.1(cre)Fjd} mutation (0 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:131721 )

• mice are viable and exhibit not visible abnormalities and remain healthy throughout 12 months of study, with normal lungs

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Scgb1a1^{tm1.1(cre)Fjd} mutation (0 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:131721 )

• mean survival is 8 weeks

immune system

lung inflammation ( J:131721 )

• increase in inflammation in lesions compared to single Kras mutants, with an increase in neutrophil and endothelial cell infiltration; infiltration of these cells increases with malignant progression

respiratory system

lung inflammation ( J:131721 )

increased lung tumor incidence ( J:131721 )

• mutants have higher numbers of lesions and more extensive tumors than single Kras mutants

• mutants develop distinct bronchial and alveolar tumors

increased lung adenoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age including proliferative atypical adenomatous hyperplasia lesions

increased lung carcinoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age that includes atypical papillary bronchiolar proliferation

increased lung adenocarcinoma incidence ( J:131721 )

• mucinous bronchioloalveolar cell carcinoma-like lesions, a subtype of lung adenocarcinoma

tachypnea ( J:131721 )

• by 2 months of age, mutants exhibit tachypnea

neoplasm

increased lung tumor incidence ( J:131721 )

• mutants have higher numbers of lesions and more extensive tumors than single Kras mutants

• mutants develop distinct bronchial and alveolar tumors

increased lung adenoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age including proliferative atypical adenomatous hyperplasia lesions

increased lung carcinoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age that includes atypical papillary bronchiolar proliferation

increased lung adenocarcinoma incidence ( J:131721 )

• mucinous bronchioloalveolar cell carcinoma-like lesions, a subtype of lung adenocarcinoma

growth/size/body

weight loss ( J:131721 )

• by 2 months of age, mutants exhibit weight loss

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scgb1a1^tm1(cre)Fjd/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Scgb1a1^tm1(cre)Fjd mutation (0 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:159271 )

• shortened life span, with a median survival time of 10 months and no mice surviving past 12 months of age

decreased tumor-free survival time ( J:159271 )

• shortened life span due to lung tumors

neoplasm

increased lung tumor incidence ( J:159271 )

• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages

• isolated small lesions in the lungs are seen in 4- and 6-month-old mice and an increase in lesion size is seen with age

• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen

• lesions are atypical papillary bronchiolar hyperplasia, solid and papillary adenomas, adenomas with atypical cytologic features, atypical papillary bronchiolar hyperplasia adjacent to adenomas, and adenoncarcinoma

increased lung adenoma incidence ( J:159271 )

• lesions include solid and papillary adenomas and adenomas with atypical cytologic features

• adenomas are predominately of the papillary subtype

• number of adenomas is less than in Kras^tm4Tyj Scgb1a1^{tm1.1(cre)Fjd} mice but the mean size of adenomas is greater

increased lung adenocarcinoma incidence ( J:159271 )

• adenocarcinomas are only seen in the very late stage

respiratory system

lung inflammation ( J:159271 )

• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors

increased lung tumor incidence ( J:159271 )

• isolated small lesions in the lungs are seen in 4- and 6-month-old mice and an increase in lesion size is seen with age

• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen

• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages

increased lung adenoma incidence ( J:159271 )

• lesions include solid and papillary adenomas and adenomas with atypical cytologic features

• adenomas are predominately of the papillary subtype

• number of adenomas is less than in Kras^tm4Tyj Scgb1a1^{tm1.1(cre)Fjd} mice but the mean size of adenomas is greater

increased lung adenocarcinoma incidence ( J:159271 )

• adenocarcinomas are only seen in the very late stage

bronchiolar epithelial hyperplasia ( J:159271 )

• lesions include atypical papillary bronchiolar hyperplasia and atypical papillary bronchiolar hyperplasia adjacent to adenomas

• in early stages, epithelial hyperplasia is only seen in bronchioles, not in the alveolar sac area

immune system

lung inflammation ( J:159271 )

• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:159271

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:159271 )

• shortened life span, with a median survival time of 6 months and no mice surviving past 8 months of age

decreased tumor-free survival time ( J:159271 )

• shortened life span due to lung tumors

neoplasm

increased tumor growth/size ( J:159271 )

• weekly exposure to aerosolized nontypeable Haemophilus influenzae lystate (NTHi) for 8 weeks to induce chronic obstructive pulmonary disease (COPD)-like chronic airway inflammation increases lung surface tumors 3.2-fold while no tumors are seen in NTHi treated wild-type mice

increased lung tumor incidence ( J:159271 )

• isolated small lesions in the lungs are seen in 1- and 2-month-old mice and an increase in lesion size is seen with age

• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen

• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages

• early lung lesions exhibit a Clara cell phenotype indicating that lesions come from Clara Cells of conducting airways and more advanced pathologies show an alveolar type II cell phenotype

• weekly exposure to aerosolized nontypable Haemophilus influenzae lysate results in an increase in total lung tumor burden

increased lung adenoma incidence ( J:159271 )

• lesions include solid and papillary adenomas and adenomas with atypical cytologic features

• adenomas are predominately of the papillary subtype

• number of adenomas is greater than in Kras^tm4Tyj Scgb1a1^tm1(cre)Fjd mice but the mean size of adenomas is smaller

increased lung adenocarcinoma incidence ( J:159271 )

respiratory system

lung inflammation ( J:159271 )

• mice show elevated macrophage numbers in bronchoalveolar lavage fluid (BALF)

• 14-week-old mice show focal infiltration of macrophages around hyperplastic and adenomatous lesions

• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors

• mice exposed to aerosolized nontypeable Haemophilus influenzae lystate (NTHi) once weekly for 8 weeks to induce chronic obstructive pulmonary disease (COPD)-like chronic airway inflammation show dense infiltration of the lung parenchyma with macrophages, neutrophils, and lymphocytes indicating neutrophil/macrophage/CD8 T cell-associated COPD-like airway inflammation; the inflammatory infiltrate is centered around airways and blood vessels, but also extends widely into alveolar spaces

increased lung tumor incidence ( J:159271 )

• isolated small lesions in the lungs are seen in 1- and 2-month-old mice and an increase in lesion size is seen with age

• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen

• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages

• early lung lesions exhibit a Clara cell phenotype indicating that lesions come from Clara Cells of conducting airways and more advanced pathologies show an alveolar type II cell phenotype

• weekly exposure to aerosolized nontypable Haemophilus influenzae lysate results in an increase in total lung tumor burden

increased lung adenoma incidence ( J:159271 )

• lesions include solid and papillary adenomas and adenomas with atypical cytologic features

• adenomas are predominately of the papillary subtype

• number of adenomas is greater than in Kras^tm4Tyj Scgb1a1^tm1(cre)Fjd mice but the mean size of adenomas is smaller

increased lung adenocarcinoma incidence ( J:159271 )

bronchiolar epithelial hyperplasia ( J:159271 )

• in early stages, epithelial hyperplasia is only seen in bronchioles, not in the alveolar sac area

• lesions include atypical papillary bronchiolar hyperplasia and atypical papillary bronchiolar hyperplasia adjacent to adenomas

immune system

lung inflammation ( J:159271 )

• mice show elevated macrophage numbers in bronchoalveolar lavage fluid (BALF)

• 14-week-old mice show focal infiltration of macrophages around hyperplastic and adenomatous lesions

• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:159271

Allelic Composition	Foxp1^tm1.1Pwt/Foxp1^tm1.1Pwt Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Scgb1a1^tm1(icre)Fjd/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1^tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4^tm2.1Eem mutation (0 available); any Foxp4 mutation (89 available)
Scgb1a1^tm1(icre)Fjd mutation (1 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiratory system development ( J:185603 )

• mice exhibit an increase in goblet cell differentiation compared with control mice

abnormal respiratory system physiology ( J:185603 )

• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

homeostasis/metabolism

increased susceptibility to injury ( J:185603 )

• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺ Trp53^tm5Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Scgb1a1^{tm1(cre/ERT)Blh} mutation (1 available); any Scgb1a1 mutation (31 available)
Trp53^tm5Tyj mutation (1 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:182218 )

• animal succumb due to tumor burden at 20-24 weeks

neoplasm

increased lung adenoma incidence ( J:182218 )

• at 6-8 weeks of age, animals administered 4 doses of tamoxifen develop adenomas in the alveoli by 15 weeks; these progress to adenocarcinomas

• papillary adenomas are seen in alveoli at 15 and 21 weeks after tamoxifen treatment

increased adenocarcinoma incidence ( J:182218 )

• develop in alveoli and near the bronchioalveolar duct junction by 15 weeks of age with tamoxifen administration at 6-8 weeks

• larger bronchioles and non terminal bronchi appear normal

• advanced papillary adenocarcinomas are observed at 21 weeks after tamoxifen treatment

respiratory system

increased lung adenoma incidence ( J:182218 )

• at 6-8 weeks of age, animals administered 4 doses of tamoxifen develop adenomas in the alveoli by 15 weeks; these progress to adenocarcinomas

• papillary adenomas are seen in alveoli at 15 and 21 weeks after tamoxifen treatment

abnormal bronchoalveolar duct junction morphology ( J:182218 )

• hyperplasia is observed at 3 weeks after tamoxifen induction, and persists at 15 and 21 weeks

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S6/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} mutation (0 available); any Gt(ROSA)26Sor mutation (1083 available)
Scgb1a1^{tm1(cre/ERT)Blh} mutation (1 available); any Scgb1a1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

bronchial epithelial hyperplasia ( J:161806 )

• after 13 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice

• however, areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

neoplasm

neoplasm ( J:161806 )

N	• areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S6/SvEv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

increased lung adenocarcinoma incidence ( J:161806 )

• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice

bronchial epithelial hyperplasia ( J:161806 )

• after 6 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice

neoplasm

increased lung adenocarcinoma incidence ( J:161806 )

• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice

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