All Phenotypes Scgb1a1<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scgb1a1⁺
wild type
MGI:2437003

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scgb1a1^tm1Abm/Scgb1a1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:6313624
ht2	Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S4/SvJaeSor * 129S6/SvEv * C57BL/6	MGI:3850367
cn3	Kras^tm4Tyj/Kras⁺ Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4839216
cn4	Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4839214
cn5	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4839215
cn6	Foxp1^tm1.1Pwt/Foxp1^tm1.1Pwt Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Scgb1a1^tm1(icre)Fjd/Scgb1a1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5433107
cn7	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺ Trp53^tm5Tyj/Trp53⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5317170
cn8	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S6/SvEv * C57BL/6	MGI:4820811
cn9	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S6/SvEv * C57BL/6	MGI:4820809

Allelic Composition	Scgb1a1^tm1Abm/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scgb1a1^tm1Abm mutation (0 available); any Scgb1a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased IgA level ( J:57504 )

• mice exhibit moderate glomerular deposition of IgA

homeostasis/metabolism

abnormal complement protein level ( J:57504 )

• mice exhibit abnormal renal glomerular deposition of complement C3

immune system

increased IgA level ( J:57504 )

• mice exhibit moderate glomerular deposition of IgA

abnormal complement protein level ( J:57504 )

• mice exhibit abnormal renal glomerular deposition of complement C3

renal/urinary system

abnormal renal glomerulus morphology ( J:57504 )

• mice exhibit moderate glomerular deposition of IgA and deposition of complement C3

• glomeruli exhibit an abnormal deposition of an eosinophilic material which includes fibronectin and collagen

Allelic Composition	Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scgb1a1^{tm1(cre/ERT)Blh} mutation (1 available); any Scgb1a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:149822 )

• mice are viable and fertile

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Pten^tm1Hwu mutation (17 available); any Pten mutation (87 available)
Scgb1a1^{tm1.1(cre)Fjd} mutation (0 available); any Scgb1a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:131721 )

• mean survival is 8 weeks

immune system

lung inflammation ( J:131721 )

• increase in inflammation in lesions compared to single Kras mutants, with an increase in neutrophil and endothelial cell infiltration; infiltration of these cells increases with malignant progression

respiratory system

lung inflammation ( J:131721 )

increased lung tumor incidence ( J:131721 )

• mutants have higher numbers of lesions and more extensive tumors than single Kras mutants

• mutants develop distinct bronchial and alveolar tumors

increased lung adenoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age including proliferative atypical adenomatous hyperplasia lesions

increased lung carcinoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age that includes atypical papillary bronchiolar proliferation

increased lung adenocarcinoma incidence ( J:131721 )

• mucinous bronchioloalveolar cell carcinoma-like lesions, a subtype of lung adenocarcinoma

tachypnea ( J:131721 )

• by 2 months of age, mutants exhibit tachypnea

neoplasm

increased lung tumor incidence ( J:131721 )

• mutants have higher numbers of lesions and more extensive tumors than single Kras mutants

• mutants develop distinct bronchial and alveolar tumors

increased lung adenoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age including proliferative atypical adenomatous hyperplasia lesions

increased lung carcinoma incidence ( J:131721 )

• mutants develop lung lesions as early as 4 weeks of age that includes atypical papillary bronchiolar proliferation

increased lung adenocarcinoma incidence ( J:131721 )

• mucinous bronchioloalveolar cell carcinoma-like lesions, a subtype of lung adenocarcinoma

growth/size/body

weight loss ( J:131721 )

• by 2 months of age, mutants exhibit weight loss

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (17 available); any Pten mutation (87 available)
Scgb1a1^{tm1.1(cre)Fjd} mutation (0 available); any Scgb1a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:131721 )

• mice are viable and exhibit not visible abnormalities and remain healthy throughout 12 months of study, with normal lungs

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1.1(cre)Fjd}/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Scgb1a1^{tm1.1(cre)Fjd} mutation (0 available); any Scgb1a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:131721 )

• average survival is 24 weeks

respiratory system

abnormal lung morphology ( J:131721 )

• mutants develop lung lesions that are first detected at 12 weeks of age in alveoli and bronchioles

• mutants develop epithelial lesions termed atypical papillary bronchiolar proliferation that has papillary proliferations of the bronchiolar epithelium located at the bronchiolar terminal site

• however, no carcinomas are seen by 24 weeks of age

increased lung tumor incidence ( J:131721 )

• mutants develop lung lesions that are first detected at 12 weeks of age in alveoli and bronchioles

• mutants develop epithelial lesions termed atypical papillary bronchiolar proliferation that has papillary proliferations of the bronchiolar epithelium located at the bronchiolar terminal site

increased lung adenoma incidence ( J:131721 )

• atypical adenomatous hyperplasia lesions and adenomas

neoplasm

increased lung tumor incidence ( J:131721 )

• mutants develop lung lesions that are first detected at 12 weeks of age in alveoli and bronchioles

• mutants develop epithelial lesions termed atypical papillary bronchiolar proliferation that has papillary proliferations of the bronchiolar epithelium located at the bronchiolar terminal site

increased lung adenoma incidence ( J:131721 )

• atypical adenomatous hyperplasia lesions and adenomas

Allelic Composition	Foxp1^tm1.1Pwt/Foxp1^tm1.1Pwt Foxp4^tm2.1Eem/Foxp4^tm2.1Eem Scgb1a1^tm1(icre)Fjd/Scgb1a1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1^tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4^tm2.1Eem mutation (0 available); any Foxp4 mutation (89 available)
Scgb1a1^tm1(icre)Fjd mutation (1 available); any Scgb1a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiratory system development ( J:185603 )

• mice exhibit an increase in goblet cell differentiation compared with control mice

abnormal respiratory system physiology ( J:185603 )

• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

homeostasis/metabolism

increased susceptibility to injury ( J:185603 )

• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺ Trp53^tm5Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Scgb1a1^{tm1(cre/ERT)Blh} mutation (1 available); any Scgb1a1 mutation (30 available)
Trp53^tm5Tyj mutation (1 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:182218 )

• animal succumb due to tumor burden at 20-24 weeks

neoplasm

increased lung adenoma incidence ( J:182218 )

• at 6-8 weeks of age, animals administered 4 doses of tamoxifen develop adenomas in the alveoli by 15 weeks; these progress to adenocarcinomas

• papillary adenomas are seen in alveoli at 15 and 21 weeks after tamoxifen treatment

increased adenocarcinoma incidence ( J:182218 )

• develop in alveoli and near the bronchioalveolar duct junction by 15 weeks of age with tamoxifen administration at 6-8 weeks

• larger bronchioles and non terminal bronchi appear normal

• advanced papillary adenocarcinomas are observed at 21 weeks after tamoxifen treatment

respiratory system

increased lung adenoma incidence ( J:182218 )

• at 6-8 weeks of age, animals administered 4 doses of tamoxifen develop adenomas in the alveoli by 15 weeks; these progress to adenocarcinomas

• papillary adenomas are seen in alveoli at 15 and 21 weeks after tamoxifen treatment

abnormal bronchoalveolar duct junction morphology ( J:182218 )

• hyperplasia is observed at 3 weeks after tamoxifen induction, and persists at 15 and 21 weeks

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S6/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Scgb1a1^{tm1(cre/ERT)Blh} mutation (1 available); any Scgb1a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

bronchial epithelial hyperplasia ( J:161806 )

• after 13 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice

• however, areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

neoplasm

neoplasm ( J:161806 )

N	• areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S6/SvEv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

increased lung adenocarcinoma incidence ( J:161806 )

• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice

bronchial epithelial hyperplasia ( J:161806 )

• after 6 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice

neoplasm

increased lung adenocarcinoma incidence ( J:161806 )

• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24