Scgb1a1^{tm1(cre/ERT)Blh}
Targeted Allele Detail

Summary

• Symbol: Scgb1a1^{tm1(cre/ERT)Blh}
• Name: secretoglobin, family 1A, member 1; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:3849566
• Synonyms: CC10-CreER, Scgb1a1-CreEr^TM
• Gene: Scgb1a1 Location: Chr19:9061006-9065320 bp, - strand Genetic Position: Chr19, 6.05 cM, cytoband A
• Alliance: Scgb1a1^{tm1(cre/ERT)Blh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149822
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Scgb1a1^{tm1(cre/ERT)Blh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scgb1a1 (MGI:98919)

• Mutation details: An IRESCreERT-lox-PGKneo-lox cassette was knocked into the 3' UTR of a 9.3 kb fragment of the Scgb1a1 locus. The targeting construct was electroporated into 129/SvEv ES cells for homologous recombination. Chimeras were generated by blastocyst injection of recombined ES cells. The PGK-neo cassette was deleted by crosses with Gt(ROSA)26Sor^tm1(FLP1)Dym (FLPeR) mice. Cre expression from the Scgb1a1 locus is induced by tamoxifen administration. (J:149822)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scgb1a1 (mouse) Summary of all recombinase alleles driven by Scgb1a1. Comparative matrix view of recombinase activities Alliance mouse Scgb1a1 gene page

Tumor Data

List all tumor models in MMHCdb carrying Scgb1a1^{tm1(cre/ERT)Blh}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scgb1a1 Mutation: 26 strains or lines available

References

• Original: J:149822 Rawlins EL, et al., The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell. 2009 Jun 5;4(6):525-34
• All: 61 reference(s)