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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myd88+
wild type
MGI:2436005
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Myd88M4Btlr/Myd88+ C57BL/6J-Myd88M4Btlr MGI:6113643
ht2
 		Myd88poc/Myd88+ C57BL/6-Myd88poc MGI:3641256
cn3
 		Ighg1tm1(cre)Cgn/Ighg1+
Myd88em1.1Rsky/Myd88+ 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:7281484
cn4
 		Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+ 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:7281485
cn5
 		Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88+ 		involves: C57BL/6NTac MGI:7281482
cx6
 		Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88+ 		B6.129-Myd88tm1Aki Ifnar1tm1Agt MGI:5432885


Genotype
MGI:6113643
ht1
Allelic
Composition		 Myd88M4Btlr/Myd88+
Genetic
Background		 C57BL/6J-Myd88M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88M4Btlr mutation (0 available); any Myd88 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254917 )
• reduced TNF secretion in response to the TLR9 ligand CpG oligodeoxynucleotides (CpG ODN) primed with IFN and the TLR7 ligand R848




Genotype
MGI:3641256
ht2
Allelic
Composition		 Myd88poc/Myd88+
Genetic
Background		 C57BL/6-Myd88poc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88poc mutation (1 available); any Myd88 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:110094 )
N
• immunoblot analysis of lysates of heterozygous mutant mouse embryonic fibroblasts (MEFs) using antibody to IkappaB demonstrates normal degradation by these cells of IkappaB in response to interleukin 1 (IL-1)




Genotype
MGI:7281484
cn3
Allelic
Composition		 Ighg1tm1(cre)Cgn/Ighg1+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (4 available); any Ighg1 mutation (30 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:308792 )
N
• normal Ig class switching in germinal center B cells after immunization with hapten-carrier conjugate NP-CGG
• normal rise and fall of hapten-specific IgG levels after immunization with hapten-carrier conjugate NP-CGG
abnormal somatic hypermutation frequency ( J:308792 )
• increased frequency in IgM+ plasma cells
increased germinal center B cell number ( J:308792 )
• increased frequency and number
increased plasma cell number ( J:308792 )
• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of plasma cells and germinal center B cells
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

immune system
abnormal somatic hypermutation frequency ( J:308792 )
• increased frequency in IgM+ plasma cells
increased germinal center B cell number ( J:308792 )
• increased frequency and number
increased plasma cell number ( J:308792 )
• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of plasma cells and germinal center B cells
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
monoclonal gammopathy of uncertain significance DOID:7442 J:308792




Genotype
MGI:7281485
cn4
Allelic
Composition		 Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre/ERT2)Rsky mutation (1 available); any Cd19 mutation (57 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

immune system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
monoclonal gammopathy of uncertain significance DOID:7442 J:308792




Genotype
MGI:7281482
cn5
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:308792 )
N
• normal B cell development in bone marrow
• normal Ig class switching in B cells in spleen, mesenteric lymph nodes and Peyers patches
enlarged spleen ( J:308792 )
• from age 30 weeks
increased germinal center B cell number ( J:308792 )
• increased frequency and number from age 30 weeks, increasing over time
increased plasma cell number ( J:308792 )
• increased number of IgM+ plasma cells
• increased plasma cell compartment in spleen and bone marrow
• increased frequency and number of TACI+ CD138+ plasma cells from age 50 weeks
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of germinal center B cells from age 30 weeks, increasing over time
• normal frequency of follicular and marginal zone B cells
increased IgM level ( J:308792 )
• increased serum levels from age 10 weeks, increasing over time

immune system
enlarged spleen ( J:308792 )
• from age 30 weeks
increased germinal center B cell number ( J:308792 )
• increased frequency and number from age 30 weeks, increasing over time
increased plasma cell number ( J:308792 )
• increased number of IgM+ plasma cells
• increased plasma cell compartment in spleen and bone marrow
• increased frequency and number of TACI+ CD138+ plasma cells from age 50 weeks
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of germinal center B cells from age 30 weeks, increasing over time
• normal frequency of follicular and marginal zone B cells
increased IgM level ( J:308792 )
• increased serum levels from age 10 weeks, increasing over time

growth/size/body
enlarged spleen ( J:308792 )
• from age 30 weeks




Genotype
MGI:5432885
cx6
Allelic
Composition		 Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88+
Genetic
Background		 B6.129-Myd88tm1Aki Ifnar1tm1Agt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (13 available); any Ifnar1 mutation (62 available)
Myd88tm1Aki mutation (9 available); any Myd88 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:140485 )
• in cultured bone marrow dendritic cells from mice infected with Trypanosoma cruzi the number of trypomastigotes released into the supernatant is slightly increased and the replication within macrophages is slightly enhanced compared to controls
• slight increase in the number of trypomastigotes in the serum of T. cruzi infected mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory