All Phenotypes Ezh2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ezh2⁺
wild type
MGI:2434016

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ezh2^em1Jbn/Ezh2⁺	C57BL/6J-Ezh2^em1Jbn	MGI:6275998
ht2	Ezh2^em1Jiaf/Ezh2⁺	C57BL/6J-Ezh2^em1Jiaf	MGI:7611833
ht3	Ezh2^{tm1a(EUCOMM)Wtsi}/Ezh2⁺	C57BL/6N-Ezh2^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5781623
cn4	Ezh2^tm1.1Nesh/Ezh2⁺ Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:6393679
cn5	Braf^tm1Mmcm/Braf⁺ Ezh2^tm1.1Nesh/Ezh2⁺ Tg(Tyr-cre/ERT2)13Bos/0	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB	MGI:6393921
cn6	Ezh2^tm1.1Nesh/Ezh2⁺ Nras^tm1.1Nesh/Nras⁺ Tg(Tyr-cre/ERT2)13Bos/0	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB	MGI:6393932
cn7	Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Ezh2^tm1.1Nesh/Ezh2⁺ Nras^tm1.1Nesh/Nras⁺ Tg(Tyr-cre/ERT2)13Bos/0	involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB	MGI:6393935
cn8	Ezh2^tm2Sho/Ezh2⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Kdm6b^tm1.1Rbo/Kdm6b^tm1.1Rbo	involves: 129S1/Sv * 129S4/SvJae * C57BL/6J * CBA/J	MGI:7338996

Allelic Composition	Ezh2^em1Jbn/Ezh2⁺
Genetic Background	C57BL/6J-Ezh2^em1Jbn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^em1Jbn mutation (1 available); any Ezh2 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased heart weight ( J:267184 )

• increased heart weight at 8 weeks of age

growth/size/body

increased heart weight ( J:267184 )

• increased heart weight at 8 weeks of age

increased body weight ( J:267184 )

• by 8 weeks of age, body weight is increased in comparison to controls

• increase is more prominent in females

increased growth rate ( J:267184 )

• is observed by 8 weeks of age

increased kidney weight ( J:267184 )

• increased kidney weight at 8 weeks of age

increased spleen weight ( J:267184 )

• increased spleen weight at 8 weeks of age

hematopoietic system

increased spleen weight ( J:267184 )

• increased spleen weight at 8 weeks of age

immune system

increased spleen weight ( J:267184 )

• increased spleen weight at 8 weeks of age

renal/urinary system

increased kidney weight ( J:267184 )

• increased kidney weight at 8 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Weaver syndrome		DOID:14731	OMIM:277590	J:267184

Allelic Composition	Ezh2^em1Jiaf/Ezh2⁺
Genetic Background	C57BL/6J-Ezh2^em1Jiaf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^em1Jiaf mutation (0 available); any Ezh2 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:345603 )

N	• normal tibia and femur lengths at age 8 weeks • normal trabecular bone structure in distal femur

abnormal osteoblast physiology ( J:345603 )

• increased periosteal and endosteal mineral apposition rate (MAR) in females

• increased endosteal mineral apposition rate (MAR) in males

increased femur compact bone thickness ( J:345603 )

• at femoral middiaphysis

increased internal diameter of femur ( J:345603 )

• increased tissue diameter at femoral middiaphysis, leading to reduced bone/tissue ratio

growth/size/body

growth/size/body region phenotype ( J:345603 )

N	• normal body length in males and females • normal body weight in males

increased body weight ( J:345603 )

• at ages 8-22 weeks

• normal body weight in males

limbs/digits/tail

increased femur compact bone thickness ( J:345603 )

• at femoral middiaphysis

increased internal diameter of femur ( J:345603 )

• increased tissue diameter at femoral middiaphysis, leading to reduced bone/tissue ratio

mortality/aging

mortality/aging ( J:345603 )

N	• mice born at expected Mendelian ratios

cellular

abnormal osteoblast physiology ( J:345603 )

• increased periosteal and endosteal mineral apposition rate (MAR) in females

• increased endosteal mineral apposition rate (MAR) in males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Weaver syndrome		DOID:14731	OMIM:277590	J:345603

Allelic Composition	Ezh2^{tm1a(EUCOMM)Wtsi}/Ezh2⁺
Genetic Background	C57BL/6N-Ezh2^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0052_2_C05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Ezh2 mutation (70 available)

Data Sources

IMPC Data for Ezh2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased mean corpuscular hemoglobin ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

increased circulating triglyceride level ( J:175295 )

IMPC - WTSI

skeleton

increased sacral vertebrae number ( J:175295 )

IMPC - WTSI

Allelic Composition	Ezh2^tm1.1Nesh/Ezh2⁺ Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Ezh2^tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:239472 )

• median survival of 1 year

neoplasm

increased leukemia incidence ( J:239472 )

• about 50% of mice show frank leukemia and/or hepatic involvement

increased B cell derived lymphoma incidence ( J:239472 )

• mice develop B cell lymphoma with a median survival of 1 year

• tumors show a CD45+B220+CD19+IgM+CD43+CD5+ immunophenotype

• mice treated with JQEZ5, an S-5'adenosyl-l-methionine (SAM)-competitive pyridinone inhibitor, for 6 days show completely cleared malignant population from the spleen without depleting normal B cells

immune system

abnormal spleen morphology ( J:239472 )

• tumor-bearing mice show disruption of the splenic architecture

enlarged spleen ( J:239472 )

abnormal spleen white pulp morphology ( J:239472 )

• tumor-bearing mice show expansion of abnormal, large lymphoid cells in the white pulp

enlarged lymph nodes ( J:239472 )

hematopoietic system

abnormal spleen morphology ( J:239472 )

• tumor-bearing mice show disruption of the splenic architecture

enlarged spleen ( J:239472 )

abnormal spleen white pulp morphology ( J:239472 )

• tumor-bearing mice show expansion of abnormal, large lymphoid cells in the white pulp

growth/size/body

enlarged spleen ( J:239472 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
B-cell lymphoma		DOID:707		J:239472

Allelic Composition	Braf^tm1Mmcm/Braf⁺ Ezh2^tm1.1Nesh/Ezh2⁺ Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Mmcm mutation (4 available); any Braf mutation (61 available)
Ezh2^tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased melanoma incidence ( J:239472 )

• tamoxifen-treated mice show accelerated tumorigenesis of unpigmented, nonmetastatic melanoma compared to single Braf conditional mutants

Allelic Composition	Ezh2^tm1.1Nesh/Ezh2⁺ Nras^tm1.1Nesh/Nras⁺ Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)
Nras^tm1.1Nesh mutation (2 available); any Nras mutation (42 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:239472 )

N	• tamoxifen-treated mice do not show acceleration of melanomagenesis and do not form melanoma compared to single Nras conditional mutants

Allelic Composition	Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Ezh2^tm1.1Nesh/Ezh2⁺ Nras^tm1.1Nesh/Nras⁺ Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Nesh mutation (4 available); any Cdkn2a mutation (67 available)
Ezh2^tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)
Nras^tm1.1Nesh mutation (2 available); any Nras mutation (42 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased melanoma incidence ( J:239472 )

• tamoxifen-treated mice develop melanoma similarly to conditional Nras and Cdkn2a double mutants

Allelic Composition	Ezh2^tm2Sho/Ezh2⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Kdm6b^tm1.1Rbo/Kdm6b^tm1.1Rbo
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^tm2Sho mutation (1 available); any Ezh2 mutation (70 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Kdm6b^tm1.1Rbo mutation (1 available); any Kdm6b mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:323190 )

N	• development of the palatine processes of the maxilla and palatine bones and proliferation and differentiation of palatal mesenchymal cells are restored by conditional deletion of one copy of Ezh2 compared to mutant mice with wild-type Ezh2

cleft palate ( J:323190 )

• conditional deletion of one copy of Ezh2 rescues cleft palate with 70% efficiency

digestive/alimentary system

cleft palate ( J:323190 )

• conditional deletion of one copy of Ezh2 rescues cleft palate with 70% efficiency

growth/size/body

cleft palate ( J:323190 )

• conditional deletion of one copy of Ezh2 rescues cleft palate with 70% efficiency

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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