All Phenotypes Reln<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Reln⁺
wild type
MGI:2433139

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Reln^rl/Reln⁺	B6C3Fe a/a-Reln^rl/J	MGI:5661067
ht2	Reln^rl/Reln⁺	B6.Cg-Reln^rl	MGI:5689835
ht3	Reln^em1(IMPC)Mbp/Reln⁺	C57BL/6N-Reln^em1(IMPC)Mbp/MbpMmucd	MGI:6408613
ht4	Reln^rl/Reln⁺	involves: BALB/c	MGI:3720601
cn5	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Reln^rl/Reln⁺ Trp73^tm1(cre)Agof/Trp73⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:4365610
cn6	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Reln^rl/Reln⁺ Wnt3a^tm1(cre)Eag/Wnt3a⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:4365611
cn7	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Reln^rl/Reln⁺ Trp73^tm1(cre)Agof/Trp73⁺ Wnt3a^tm1(cre)Eag/Wnt3a⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:4365612
cx8	Dab1^tm3.1Cpr/Dab1^tm3.1Cpr Reln^rl/Reln⁺	involves: 129S4/SvJaeSor * C57BL/6J	MGI:3810296
cx9	Dab1^tm1Cpr/Dab1^tm4Cpr Reln^rl/Reln⁺	involves: 129/Sv * C3HeB/Fe * C57BL/6	MGI:3050790

Allelic Composition	Reln^rl/Reln⁺
Genetic Background	B6C3Fe a/a-Reln^rl/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reln^rl mutation (3 available); any Reln mutation (209 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal ventral striatum morphology ( J:107996 )

• mice show an elevation of dopamine D3 receptor expression in the ventral striatum, particularly in the nucleus accumbens and tuberculum olfactorium

decreased dopaminergic neuron number ( J:107996 )

• mice exhibit a reduction in the number of tyrosine hydroxylase-immunoreactive cell bodies in the ventral tegmental area, but not in the medial substantia nigra, pars compacta, indicating dopamine cell loss in the ventral striatum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:107996

Allelic Composition	Reln^rl/Reln⁺
Genetic Background	B6.Cg-Reln^rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reln^rl mutation (3 available); any Reln mutation (209 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal short-term spatial reference memory ( J:223944 )

• chronic administration of corticosterone to induce high stress hormone levels results in disrupted short-term spatial memory in both males and females as indicated by mice showing no preference for the novel arm of the Y-maze as seen in controls

• however, unstressed mutants show normal spatial memory on the Y-maze

abnormal social investigation ( J:223944 )

• untreated and corticosterone treated (stressed) males spend less time sniffing a novel mouse during phase 2 of the social recognition test when mice can choose between a novel and a familiar mouse, indicating impaired social recognition memory

nervous system

abnormal prepulse inhibition ( J:223944 )

• corticosterone treated males do not exhibit disrupted prepulse inhibition as is seen in wild-type corticosterone treated males, indicating that males are resilient to the effects of stress on prepulse inhibition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:223944

Allelic Composition	Reln^em1(IMPC)Mbp/Reln⁺
Genetic Background	C57BL/6N-Reln^em1(IMPC)Mbp/MbpMmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reln^em1(IMPC)Mbp mutation (1 available); any Reln mutation (209 available)

Data Sources

IMPC Data for Reln

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

no spontaneous movement ( J:211773 )

IMPC - UCD

immune system

abnormal lymph node morphology ( J:211773 )

IMPC - UCD

enlarged lymph nodes ( J:211773 )

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

IMPC - UCD

Allelic Composition	Reln^rl/Reln⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reln^rl mutation (3 available); any Reln mutation (209 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:42417 )

N	• cerebellum is normally foliated and qualitatively indistinguishable from that of wild-type controls

Purkinje cell degeneration ( J:42417 )

• males, but not females, have a 16% reduction in the number of Purkinje cells at 3 months of age and a 24% reduction at 16 months of age with the loss occurring throughout the mediolateral extent of the cerebellum

decreased Purkinje cell number ( J:42417 )

small cerebellum ( J:42417 )

• males, but not females, have reduction in overall cross-sectional area of the cerebella at 3 and 16 months of age

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Reln^rl/Reln⁺ Trp73^tm1(cre)Agof/Trp73⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1083 available)
Reln^rl mutation (3 available); any Reln mutation (209 available)
Trp73^tm1(cre)Agof mutation (0 available); any Trp73 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased Cajal-Retzius cell number ( J:153209 )

• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 72% at P0

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Reln^rl/Reln⁺ Wnt3a^tm1(cre)Eag/Wnt3a⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1083 available)
Reln^rl mutation (3 available); any Reln mutation (209 available)
Wnt3a^tm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased Cajal-Retzius cell number ( J:153209 )

• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 35% at P0

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Reln^rl/Reln⁺ Trp73^tm1(cre)Agof/Trp73⁺ Wnt3a^tm1(cre)Eag/Wnt3a⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased Cajal-Retzius cell number ( J:153209 )

• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0

• nearly all CRc in the hippocampal formation are ablated

Allelic Composition	Dab1^tm3.1Cpr/Dab1^tm3.1Cpr Reln^rl/Reln⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm3.1Cpr mutation (0 available); any Dab1 mutation (78 available)
Reln^rl mutation (3 available); any Reln mutation (209 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:74239 )

N	• the hippocampus and neocortex are normal

Allelic Composition	Dab1^tm1Cpr/Dab1^tm4Cpr Reln^rl/Reln⁺
Genetic Background	involves: 129/Sv * C3HeB/Fe * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (78 available)
Dab1^tm4Cpr mutation (0 available); any Dab1 mutation (78 available)
Reln^rl mutation (3 available); any Reln mutation (209 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:91679 )

• the marginal zone of the cortex is reduced, similar to compound heterozygous mice wild-type for Reln

abnormal hippocampus morphology ( J:91679 )

• the hippocampus is subtly disorganized in the CA2/3 region compared to mice heterozygous for Dab1^tm1Cpr and Reln^rl

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