All Phenotypes Tcrb<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcrb⁺
wild type
MGI:2432305

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tcrb^Ln3Jae/Tcrb⁺	B6.Cg-Tcrb^Ln3Jae	MGI:3834659
cn2	Gt(ROSA)26Sor^{tm10(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb⁺ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ	MGI:5314090
cn3	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb⁺ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5314091
cx4	Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺	B6.Cg-Tcrb^Ln3Jae Tcra^Ln3Jae	MGI:3834654
cx5	Tcrb^tm1Mom/Tcrb⁺ Tg(SOD1*G93A)1Gur/0	B6.Cg-Tcrb^tm1Mom Tg(SOD1*G93A)1Gur/J	MGI:4822435
cx6	Tcra^Ln1Ogu/Tcra⁺ Tcrb^Ln1Ogu/Tcrb⁺	involves: 129/Sv * C57BL/6	MGI:4356144
cx7	Tcra^Ln2Ogu/Tcra⁺ Tcrb^Ln2Ogu/Tcrb⁺	involves: 129/Sv * C57BL/6	MGI:4356145
cx8	Rag2^tm1Fwa/Rag2^tm1Fwa Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:3834655
cx9	Rag2^tm1Fwa/Rag2^tm1Fwa Tcrb^Ln3Jae/Tcrb⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:3834656

Allelic Composition	Tcrb^Ln3Jae/Tcrb⁺
Genetic Background	B6.Cg-Tcrb^Ln3Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrb^Ln3Jae mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-negative T cell morphology ( J:143006 )

• the DN3 population in these mice is reduced by about half

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

hematopoietic system

abnormal double-negative T cell morphology ( J:143006 )

• the DN3 population in these mice is reduced by about half

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

Allelic Composition	Gt(ROSA)26Sor^{tm10(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb⁺ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Gt(ROSA)26Sor^{tm10(Lmp1)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Tcrb^tm1Mom mutation (12 available); any Tcrb mutation (98 available)
Tcrd^tm1Mom mutation (13 available); any Tcrd mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged spleen ( J:181546 )

Allelic Composition	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb⁺ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Gt(ROSA)26Sor^{tm11(Lmp1)Rsky} mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Tcrb^tm1Mom mutation (12 available); any Tcrb mutation (98 available)
Tcrd^tm1Mom mutation (13 available); any Tcrd mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged spleen ( J:181546 )

Allelic Composition	Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺
Genetic Background	B6.Cg-Tcrb^Ln3Jae Tcra^Ln3Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln3Jae mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln3Jae mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

abnormal T cell differentiation ( J:143006 )

• the pre-arranged TCR genes are expressed abnormally early with intracellular TCR-beta chains detectable in the 75% of the common lymphoid progenitors in the bone marrow

• these TCR-beta chains were also detectable in 35% of multipotent progenitors, 12% of short-term hemopoietic stem cells, and 5% of long-term hemopoietic stem cells of the bone marrow

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is rarely found in the spleen

decreased double-positive T cell number ( J:143006 )

• there is a greater than 4-fold reduction in the percentage of double-positive thymocytes

• the double-positive thymus makes up 83% of the normal thymus but only 16% in these mutants

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 10-fold increase in the percentage of CD8⁺ single positive thymocytes

• the percentage of CD8⁺ T cells among splenocytes is more than double that of controls

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

hematopoietic system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

abnormal T cell differentiation ( J:143006 )

• the pre-arranged TCR genes are expressed abnormally early with intracellular TCR-beta chains detectable in the 75% of the common lymphoid progenitors in the bone marrow

• these TCR-beta chains were also detectable in 35% of multipotent progenitors, 12% of short-term hemopoietic stem cells, and 5% of long-term hemopoietic stem cells of the bone marrow

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is rarely found in the spleen

decreased double-positive T cell number ( J:143006 )

• there is a greater than 4-fold reduction in the percentage of double-positive thymocytes

• the double-positive thymus makes up 83% of the normal thymus but only 16% in these mutants

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 10-fold increase in the percentage of CD8⁺ single positive thymocytes

• the percentage of CD8⁺ T cells among splenocytes is more than double that of controls

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

endocrine/exocrine glands

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

Allelic Composition	Tcrb^tm1Mom/Tcrb⁺ Tg(SOD1*G93A)1Gur/0
Genetic Background	B6.Cg-Tcrb^tm1Mom Tg(SOD1*G93A)1Gur/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrb^tm1Mom mutation (12 available); any Tcrb mutation (98 available)
Tg(SOD1*G93A)1Gur mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:143173 )

• accelerated disease progression

• shorter lifespans than Tg(SOD1*G93A)1Gur and Tg(SOD1*G93A)1Gur, Tcrb^tm1Mom heterozygous mice

growth/size/body

weight loss ( J:143173 )

• accelerated weight loss after disease onset compared to Tg(SOD1*G93A)1Gur, Tcrb^tm1Mom heterozygous littermates, mainly after day 135

nervous system

abnormal microglial cell physiology ( J:143173 )

• decreased microglia reactivity

motor neuron degeneration ( J:143173 )

• accelerated disease progression

• motor neuron loss in spinal cords earlier at day 140

• accelerated motor decline after disease onset compared to Tg(SOD1*G93A)1Gur, Tcrb^tm1Mom heterozygous littermates, mainly after day 135

immune system

abnormal microglial cell physiology ( J:143173 )

• decreased microglia reactivity

hematopoietic system

abnormal microglial cell physiology ( J:143173 )

• decreased microglia reactivity

cellular

abnormal microglial cell physiology ( J:143173 )

• decreased microglia reactivity

Allelic Composition	Tcra^Ln1Ogu/Tcra⁺ Tcrb^Ln1Ogu/Tcrb⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln1Ogu mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln1Ogu mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:152069 )

• mice are heavier than controls

immune system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

hematopoietic system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

Allelic Composition	Tcra^Ln2Ogu/Tcra⁺ Tcrb^Ln2Ogu/Tcrb⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln2Ogu mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln2Ogu mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:152069 )

• mice are heavier than controls

immune system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

hematopoietic system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (46 available); any Rag2 mutation (121 available)
Tcra^Ln3Jae mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln3Jae mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up less than 1% of the splenocyte population

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• 99% of T cells in the spleen are CD8⁺ T cells

• 46% of thymocytes are single-positive CD8⁺ cells

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

hematopoietic system

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up less than 1% of the splenocyte population

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• 99% of T cells in the spleen are CD8⁺ T cells

• 46% of thymocytes are single-positive CD8⁺ cells

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Tcrb^Ln3Jae/Tcrb⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (46 available); any Rag2 mutation (121 available)
Tcrb^Ln3Jae mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

increased double-positive T cell number ( J:143006 )

• double-positive T cells make up 95% of the cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up about 3% of the splenocyte population

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

hematopoietic system

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

increased double-positive T cell number ( J:143006 )

• double-positive T cells make up 95% of the cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up about 3% of the splenocyte population

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

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