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Symbol: |
TcrbLn3Jae |
Name: |
T cell receptor beta chain; recombination line 3, Rudolf Jaenisch |
MGI ID: |
MGI:3834628 |
Synonyms: |
LN3beta, Vbeta14NT |
Gene: |
Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C
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Strain of Origin: |
(129S4/SvJae x C57BL/6)F1
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Allele Type: |
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Not Applicable |
Mutation: |
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Other
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Mutation details: This allele was created by transfer of a male alpha-beta T cell nucleus into an enucleated oocyte. A blastocyte was grown and from this an ES cell clone was derived. The two Tcra alleles in this ES cell were recombined with one a productive, in frame recombination and the other a non-productive, out of frame recombination. Only the productive allele containing a Vbeta1-D1-J1.4 recombination was propagated and is the one described here. Recombination was determined by Southern blotting and inverted PCR.
(J:143006)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tcrb Mutation: |
94 strains or lines available
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Original: |
J:143006 Serwold T, et al., Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. J Immunol. 2007 Jul 15;179(2):928-38 |
All: |
7 reference(s) |
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