Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cdh1+ wild type MGI:2430281 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop intestinal adenocarcinomas with a median tumor-free survival of 5.2 months of age and no distant metastases are seen
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• mice develop intestinal adenocarcinomas with a median tumor-free survival of 5.2 months of age and no distant metastases are seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age
• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen
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• 33% of mice show lung metastasis
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• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age
• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen
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• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age
• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most common cause of death is duodenal obstruction, followed by gastric outlet obstruction
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• 36% of mice develop duodenal adenocarcinomas
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• 84% of mice develop spontaneous tumors in the glandular stomach with a median tumor-free survival of 8 months
• gastric tumors resemble diffuse-type gastric adenocarcinomas, are E-cadherin-negative, and are invasive into the muscle layers and regional lymph nodes
• intramucosal adenocarcinomas with signet ring cell feature is seen in 2 of 4 mice at 6 months of age
• gastric premalignant lesions such as atrophic gastritis, metaplasia or dysplasia are not seen at 4 and 5 months of age
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• 3 of 21 mice with gastric adenocarcinomas develop lung metastases
• metastatic lesions have similar cytologic features to primary gastric tumors
• 8% of mice exhibit adenocarcinomas in the pancreas, most likely due to invasion of the primary duodenal or gastric adenocarcinomas
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• 24% of mice develop forestomach squamous cell carcinomas
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• 36% of mice develop duodenal adenocarcinomas
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• 84% of mice develop spontaneous tumors in the glandular stomach with a median tumor-free survival of 8 months
• gastric tumors resemble diffuse-type gastric adenocarcinomas, are E-cadherin-negative, and are invasive into the muscle layers and regional lymph nodes
• intramucosal adenocarcinomas with signet ring cell feature is seen in 2 of 4 mice at 6 months of age
• gastric premalignant lesions such as atrophic gastritis, metaplasia or dysplasia are not seen at 4 and 5 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| stomach cancer | DOID:10534 |
OMIM:613659 |
J:212549 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females develop mammary tumors with a median latency of around 290 days
• mammary tumors are either intermediate-grade adenocarcinoma or solid carcinoma/carcinosarcoma
• virgin females develop mammary tumors with identical incidence and latency as uniparous females
• tumor spectrum, invasiveness and metastatic dissemination are similar in virgin and parous females
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• some mice develop intermediate-grade adenocarcinoma
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• females develop mammary tumors with a median latency of around 290 days
• mammary tumors are either intermediate-grade adenocarcinoma or solid carcinoma/carcinosarcoma
• virgin females develop mammary tumors with identical incidence and latency as uniparous females
• tumor spectrum, invasiveness and metastatic dissemination are similar in virgin and parous females
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• some mice develop intermediate-grade adenocarcinoma
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• females develop mammary tumors with a median latency of around 290 days
• mammary tumors are either intermediate-grade adenocarcinoma or solid carcinoma/carcinosarcoma
• virgin females develop mammary tumors with identical incidence and latency as uniparous females
• tumor spectrum, invasiveness and metastatic dissemination are similar in virgin and parous females
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• some mice develop intermediate-grade adenocarcinoma
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show longer tumor latency periods (330 days) compared to double conditional knockouts (214 days)
• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands
• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology
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• small numbers of skin carcinomas develop with latency of 330 days develop
• may be classified as pilomatriculomas or squamous cell carcinomas, without metastasis
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• mice show longer tumor latency periods (330 days) compared to double conditional knockouts (214 days)
• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands
• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology
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• small numbers of skin carcinomas develop with latency of 330 days develop
• may be classified as pilomatriculomas or squamous cell carcinomas, without metastasis
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• mice show longer tumor latency periods (330 days) compared to double conditional knockouts (214 days)
• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands
• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop an average of 11.3 tumors per animal in the small intestine unlike wild-type mice
• mice develop more tumors than in Apctm1Rak heterozygotes with tumor size the same as in Apctm1Rak heterozygotes
• tumors are invasive although no metastasis is detected
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• 5-fold more mice develop gastric cancer compared to in Apctm1Rak heterozygotes
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• mice develop an average of 11.3 tumors per animal in the small intestine unlike wild-type mice
• mice develop more tumors than in Apctm1Rak heterozygotes with tumor size the same as in Apctm1Rak heterozygotes
• tumors are invasive although no metastasis is detected
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• 5-fold more mice develop gastric cancer compared to in Apctm1Rak heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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