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Allele Symbol Allele Name Allele ID |
Nfe2l2tm1Mym targeted mutation 1, Masayuki Yamamoto MGI:2385925 |
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| Summary |
13 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slightly in mice fed normal chow
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| N |
• mice exhibit normal fasting blood glucose level and insulin sensitivity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• teeth exhibit reduced acid resistance compared with wild-type teeth
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• incisors are greyish white in color unlike in wild-type mice
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• iron content in the enamel surface is reduced compared to in wild-type mice
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• premature degenerative atrophy at the late maturation stage
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• mice exhibit defective iron transport from blood vessels to the ameloblasts compared with wild-type mice
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• decreased in the enamel surface
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• teeth exhibit reduced acid resistance compared with wild-type teeth
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• incisors are greyish white in color unlike in wild-type mice
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• iron content in the enamel surface is reduced compared to in wild-type mice
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• premature degenerative atrophy at the late maturation stage
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• teeth exhibit reduced acid resistance compared with wild-type teeth
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• incisors are greyish white in color unlike in wild-type mice
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• iron content in the enamel surface is reduced compared to in wild-type mice
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• premature degenerative atrophy at the late maturation stage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice fed ethanol die within 24 hours unlike similarly treated wild-type mice
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• in moribund mice are fed ethanol unlike similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in IL6 serum levels unlike similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
• LPS-treated mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
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• moribund ethanol fed mice exhibit an increase in alanine transaminase levels compared with similarly treated moribund wild-type mice
• ethanol fed mice treated with LPS exhibit a greater increase in alanine transaminase serum levels compared with similarly treated wild-type mice
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• mice fed ethanol exhibit mortality, cachexia, severe macrovesicular steatosis, increased apoptosis of hepatocytes, increased serum TNF-alpha and IL6 levels, focal hepatic inflammation, increased in alanine transaminase levels, and hypoglycemic serum glucose levels compared with similarly treated wild-type mice
• however, ethanol-induces oxidative damage and liver regeneration are normal
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• all mice fed ethanol die within 24 hours unlike similarly treated wild-type mice
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• mice fed ethanol exhibit an increase in hepatocyte apoptosis compare with similarly treated wild-type mice
• LPS-treatment of ethanol fed mice increases hepatocyte apoptosis compared to in similarly treated wild-type mice
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• mice fed ethanol develop focal inflammation unlike similarly treated wild-type mice
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• moribund mice fed ethanol develop severe macrovesicular steatosis that is most prominent in the perivenous and midzonal regions compared with microvascular steatosis that develops in similarly treated wild-type mice
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• regardless of treatment with 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)imidazole (CDDO-Im), LPS-exposed mice exhibit a greater increase in retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in IL6 serum levels unlike similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
• LPS-treated mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
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• LPS-treated mice exhibit a greater increase in reactive oxygen species in the retinal pigmented epithelium and ciliary body and retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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• mice fed ethanol develop focal inflammation unlike similarly treated wild-type mice
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• mice fed ethanol exhibit an increase in hepatocyte apoptosis compare with similarly treated wild-type mice
• LPS-treatment of ethanol fed mice increases hepatocyte apoptosis compared to in similarly treated wild-type mice
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• regardless of treatment with 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)imidazole (CDDO-Im), LPS-exposed mice exhibit a greater increase in retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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• LPS-treated mice exhibit a greater increase in reactive oxygen species in the retinal pigmented epithelium and ciliary body compared with similarly treated wild-type mice
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• regardless of treatment with 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)imidazole (CDDO-Im), LPS-exposed mice exhibit a greater increase in retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• DSS-treated mice exhibit a increased reduction in colon length, crypt loss, and inflammation compared with similarly treated wild-type mice
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• DSS-treated mice exhibit a increased reduction in colon length, crypt loss, and inflammation compared with similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following intracerebral hemorrhage, mice exhibit increased neurological deficits including attributes of body symmetry, circling behavior, and compulsory circling compared with similarly treated wild-type mice
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• following intracerebral hemorrhage, mice exhibit increased circling behavior and compulsory circling compared with similarly treated wild-type mice
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• mice subjected to intracerebral hemorrhage exhibit increased infarct size, neutrophil infiltration, reactive oxygen species production, DNA damage, and neurological deficits including attributes of body symmetry, circling behavior, and compulsory circling compared with similarly treated wild-type mice
• however, neuronal degeneration is not statistically different
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• following intracerebral hemorrhage
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• following intracerebral hemorrhage, mice exhibit increased infiltration of neutrophils at the site of injury compared with similarly treated wild-type mice
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• mice subjected to intracerebral hemorrhage exhibit increased infarct size, neutrophil infiltration, reactive oxygen species production, DNA damage, and neurological deficits including attributes of body symmetry, circling behavior, and compulsory circling compared with similarly treated wild-type mice
• however, neuronal degeneration is not statistically different
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• following intracerebral hemorrhage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female mice die by 100 weeks of age
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• female mice exhibit a slight increase in spleen weight to body weight compared with wild-type mice
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• at 60 weeks, female mice exhibit a decrease in CD4+CD8- T cells in the spleen compared with wild-type mice
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• at 60 weeks, female mice exhibit a decrease in CD4+CD8- T cells in the spleen compared with wild-type mice
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• at 60 weeks in female mice
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• at 60 weeks in female mice
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• bleomycin-treated mice exhibit increased proliferation of alveolar macrophages compared with similarly treated wild-type mice
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• rare in female mice
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• in female mice
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• at 60 weeks in female mice
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• at 60 weeks of age, female mice exhibit severe glomerular lesions unlike wild-type mice
• female mice develop glomerulonephritis unlike wild-type mice
• female mice exhibit severe nephritis with interstitial inflammation unlike wild-type mice
• however, male mice do not exhibit nephritis
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• bleomycin-treated mice exhibit increased lung inflammation with increased lymphocyte, neutrophils, and epithalial cell counts in bronchoalveolar lavage fluid and lung damage compared with similarly treated wild-type mice
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• at 60 weeks, female mice exhibit lobular formation and moderate to severe cellular proliferation compared with wild-type mice
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• at 60 weeks in female mice
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• in female mice
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• female mice exhibit subepithelial electron-dense deposits unlike wild-type mice
• female mice exhibit a collapsed glomerulus unlike wild-type mice
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• female mice exhibit IgG, IgM, and C3 depositions and faint IgA depositions in the capillary walls of the glomeruli unlike in wild-type mice
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• at 60 weeks of age, female mice exhibit severe glomerular lesions unlike wild-type mice
• female mice develop glomerulonephritis unlike wild-type mice
• female mice exhibit severe nephritis with interstitial inflammation unlike wild-type mice
• however, male mice do not exhibit nephritis
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• female mice exhibit IgG and IgM deposits in mesangial regions unlike in wild-type mice
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• 50-week-old female mice exhibit moderate mesangial proliferation with cellular crescents unlike wild-type mice
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• female mice exhibit cellular proliferation and segmental sclerosis with a circumferential fibrocellular crescent and a collapsed glomerulus unlike wild-type mice
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• at 60 weeks of age, female mice exhibit glomerular crescent formation
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• at 60 weeks in female mice
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• in female mice
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• oltipraz-treated mice fail to exhibit a reduction in tumor formation unlike similarly treated wild-type mice
(J:68072)
• bleomycin-treated mice exhibit increased weight loss, lung to body weight, total cell, lymphocyte, neutrophils, and epithalial cell counts in bronchoalveolar lavage fluid, lung fibrosis, lung inflammation, lung damage, and cell proliferation in terminal bronchioles and alveolar bronchiolization regions around fibroproliferative foci, alveolar macrophages, type 2 cells, bronchial basal cells, and endothelium compared with similarly treated wild-type mice
(J:118068)
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• regardless of oltipaz-treatment, mice exposed to benzo[a]pyrene are more susceptible to neoplasia formation in the forestomach compared with similarly treated wild-type mice
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• 50-week-old female mice exhibit moderate mesangial proliferation with cellular crescents unlike wild-type mice
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• at 60 weeks, female mice exhibit lobular formation and moderate to severe cellular proliferation compared with wild-type mice
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• female mice exhibit an increase in lipid peroxidation compared with wild-type mice
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| N |
• mice exhibit normal hematocrit
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• female mice exhibit a slight increase in spleen weight to body weight compared with wild-type mice
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• at 60 weeks, female mice exhibit a decrease in CD4+CD8- T cells in the spleen compared with wild-type mice
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• at 60 weeks, female mice exhibit a decrease in CD4+CD8- T cells in the spleen compared with wild-type mice
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• at 60 weeks in female mice
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• at 60 weeks in female mice
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• bleomycin-treated mice exhibit increased proliferation of alveolar macrophages compared with similarly treated wild-type mice
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• regardless of oltipaz-treatment, mice exposed to benzo[a]pyrene are more susceptible to neoplasia formation in the forestomach compared with similarly treated wild-type mice
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• regardless of oltipaz-treatment, mice exposed to benzo[a]pyrene are more susceptible to neoplasia formation in the forestomach compared with similarly treated wild-type mice
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• in bleomycin-treated mice compared with similarly treated wild-type mice
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• in bleomycin-treated mice compared with similarly treated wild-type mice
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• female mice exhibit a slight increase in spleen weight to body weight compared with wild-type mice
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• in bleomycin-treated mice compared with similarly treated wild-type mice
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• bleomycin-treated mice exhibit increased proliferation of cells in terminal bronchioles and alveolar bronchiolization regions around fibroproliferative foci, alveolar macrophages, type 2 cells, bronchial basal cells, and endothelium compared with similarly treated wild-type mice
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• bleomycin-treated mice exhibit increased lung inflammation with increased lymphocyte, neutrophils, and epithalial cell counts in bronchoalveolar lavage fluid and lung damage compared with similarly treated wild-type mice
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• female mice exhibit IgG, IgM, and C3 depositions and faint IgA depositions in the capillary walls of the glomeruli unlike in wild-type mice
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• regardless of oltipaz-treatment, mice exposed to benzo[a]pyrene are more susceptible to neoplasia formation in the forestomach compared with similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• iron content in the enamel surface is reduced compared to in wild-type mice
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• in the enamel surface
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• iron content in the enamel surface is reduced compared to in wild-type mice
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• iron content in the enamel surface is reduced compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• production of oxygen reactive species is increased compared to when either gene product is absent
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• sensitivity to hydrogen peroxide treatment is increased compared to when either gene product is absent
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• in culture, macrophage cell death increases from 6.2% in wild-type cells and in Trsp null cells 31% to 53%
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the highest mortality rates occur at 3 weeks of age
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• all mice die by 7 weeks with the highest mortality rates at 3 weeks of age
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• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice
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• at 3 weeks of age, mice exhibit hepatocyte necrosis not observed in either single mutants or wild-type mice
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• at 3 weeks of age, mice exhibit liver degeneration not observed in either single mutants or wild-type mice
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• at 3 weeks of age
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• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 of 34 mice fed normal chow die between 8 and 12 weeks of severe metabolic disorders (extreme hyperglycemia, dark yellow urine and very low body weight)
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| N |
• mice fed normal chow exhibit the same skeletal muscle triglycerides and plasma free glycerol and free fatty acid levels as in Lepob homozygotes
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• in mice fed normal chow compared with Lepob homozygotes
• extreme in 4 of 34 mice fed normal chow that die between 8 and 12 weeks
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• in mice fed normal chow compared to in Lepob homozygotes
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• in mice fed normal chow compared with Lepob homozygotes
• in white adipose tissue of mice fed normal chow compared with Lepob homozygotes
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• in mice fed normal chow compared to in Lepob homozygotes
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• dark yellow urine in 4 of 34 mice fed normal chow that die between 8 and 12 weeks
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• in mice fed normal chow compared with Lepob homozygotes
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• impaired adipogenesis as determined by expression of adipogenic and anti-oxidant response genes compared with Lepob homozygotes
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• fewer small adipocytes in mice fed normal chow compared to in Lepob homozygotes
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• from 5 through 11 weeks in mice fed normal chow compared with Lepob homozygotes
• very low body weight in 4 of 34 mice fed normal chow that die between 8 and 12 weeks
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• in mice fed normal chow compared with Lepob homozygotes
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• in female mice fed normal chow after 10 weeks compared with Lepob homozygotes
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• in mice fed normal chow compared to in Lepob homozygotes
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• mild with fewer, smaller lipid droplets in mice fed normal chow compared to in Lepob homozygotes
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• dark yellow urine in 4 of 34 mice fed normal chow that die between 8 and 12 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 40% survival rate after 400 days
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• 50% of animals die within 1 week after birth for unknown reasons
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• altered metabolism of phenobarbital and butylated hydroxyanisole (BHA)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fed a high fat diet exhibit decreased atherosclerotic plaques compared with Apoetm1Unc homozygotes
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• mice fed a high fat diet exhibit improved aortic stiffness compared with Apoetm1Unc homozygotes
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• when fed a high fat diet compared with Apoetm1Unc homozygotes
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• when fed a high fat diet compared with Apoetm1Unc homozygotes
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• mice fed a high fat diet exhibit increased oxidative stress compared with Apoetm1Unc homozygotes
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• macrophages of mice fed a high fat diet exhibit decreased modified low density lipoprotein uptake compared to in Apoetm1Unc homozygotes
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• macrophages of mice fed a high fat diet exhibit decreased modified low density lipoprotein uptake compared to in Apoetm1Unc homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no observed hyperkeratotic phenotype of the esophagi and mice lived beyond 3 weeks of age
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| N |
• scaly skin was not observed
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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