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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mdm2+
wild type
MGI:2183198
Summary 17 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Mdm2tm1Bay/Mdm2+ B6.129S7-Mdm2tm1Bay MGI:3715452
ht2
Mdm2tm1Glo/Mdm2+ involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3850701
ht3
Mdm2tm1Glo/Mdm2+ involves: 129S7/SvEvBrd MGI:5140379
ht4
Mdm2tm1Mep/Mdm2+ involves: 129S7/SvEvBrd * C57BL/6 MGI:3715451
cx5
Mdm2tm1.1Ypz/Mdm2+
Tg(IghMyc)22Bri/0
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri MGI:4836994
cx6
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm3Wahl/Trp53tm3Wahl
involves: 129 MGI:3700144
cx7
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3850704
cx8
Mdm2tm1Glo/Mdm2+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3850702
cx9
Mdm2tm1Glo/Mdm2+
Trp53tm1.1Tldo/Trp53+
involves: 129S2/SvPas * 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:5524024
cx10
Mdm2tm1Glo/Mdm2+
Trp53tm3Wahl/Trp53tm3Wahl
involves: 129S4/SvJae * 129S7/SvEvBrd MGI:3700143
cx11
Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:5285192
cx12
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 MGI:3625182
cx13
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3850703
cx14
Mdm2tm1Glo/Mdm2+
Mdm4tm2.1Glo/Mdm4+
involves: 129S7/SvEvBrd MGI:5140383
cx15
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
involves: 129S7/SvEvBrd MGI:3850681
cx16
Mdm2tm1Glo/Mdm2+
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S7/SvEvBrd * C57BL/6 MGI:3625179
cx17
Mdm2tm1Bay/Mdm2+
Rpl27aSfa/Rpl27a+
involves: 129S7/SvEvBrd * C57BL/6J MGI:5140361


Genotype
MGI:3715452
ht1
Allelic
Composition
Mdm2tm1Bay/Mdm2+
Genetic
Background
B6.129S7-Mdm2tm1Bay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Bay mutation (1 available); any Mdm2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 100% of mice die by day 14 after 10 Gy irradiation

homeostasis/metabolism
• 100% of mice die by day 14 after 10 Gy irradiation




Genotype
MGI:3850701
ht2
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice treated with ionizing radiation exhibit increased mortality compared with similarly treated wild-type mice
• male mice are more sensitive to treatment with ionizing radiation than female mice

cellular
• following transformation with c-myc and activated Ras oncogenes, mouse embryonic fibroblasts exhibit 33% fewer foci compared with wild-type cells

homeostasis/metabolism
• mice treated with ionizing radiation exhibit increased mortality compared with similarly treated wild-type mice
• male mice are more sensitive to treatment with ionizing radiation than female mice




Genotype
MGI:5140379
ht3
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mild hyperpigmentation detectable beginning around 4 - 6 months of age

integument
• mild hyperpigmentation detectable beginning around 4 - 6 months of age

limbs/digits/tail
• mild hyperpigmentation detectable beginning around 4 - 6 months of age




Genotype
MGI:3715451
ht4
Allelic
Composition
Mdm2tm1Mep/Mdm2+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Mep mutation (1 available); any Mdm2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 100% of mice die by day 20 after 10 Gy irradiation

homeostasis/metabolism
• 100% of mice die by day 20 after 10 Gy irradiation




Genotype
MGI:4836994
cx5
Allelic
Composition
Mdm2tm1.1Ypz/Mdm2+
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1.1Ypz mutation (4 available); any Mdm2 mutation (53 available)
Tg(IghMyc)22Bri mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 15 weeks




Genotype
MGI:3700144
cx6
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm3Wahl/Trp53tm3Wahl
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Mdm4Gt(VICTR20)7Lex mutation (0 available); any Mdm4 mutation (191 available)
Trp53tm3Wahl mutation (0 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cell cycle arrest in irradiate MEFs is improved compared to Trp53 single homozygous MEFs but is still not as robust as in wild-type MEFs




Genotype
MGI:3850704
cx7
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Mdm4tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born in expected Mendelian ratios




Genotype
MGI:3850702
cx8
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal mortality in response to treatment with ionizing radiation




Genotype
MGI:5524024
cx9
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Trp53tm1.1Tldo/Trp53+
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Trp53tm1.1Tldo mutation (0 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some die within 3 months

hematopoietic system
• decreased compared to Trp53tm1.1Tldo/+ mice

cellular
• decreased compared to Trp53tm1.1Tldo/+ mice




Genotype
MGI:3700143
cx10
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Trp53tm3Wahl/Trp53tm3Wahl
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Trp53tm3Wahl mutation (0 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• irradiation-induced cell cycle arrest is partially restored these MEFs compared to Trp53 single homozygous MEFs




Genotype
MGI:5285192
cx11
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compared with Mdm2tm1Glo heterozygotes

hematopoietic system
• compared with Trp53tm2Wahl homozygotes
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
• severe in irradiated-mice

skeleton
• severe atrophic in irradiated-mice

immune system
• compared with Trp53tm2Wahl homozygotes
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
• severe in irradiated-mice

homeostasis/metabolism
• compared with Mdm2tm1Glo heterozygotes

endocrine/exocrine glands
• compared with Trp53tm2Wahl homozygotes




Genotype
MGI:3625182
cx12
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background
involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Mdm4Gt(VICTR20)7Lex mutation (0 available); any Mdm4 mutation (191 available)
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• presence of one copy of Mdm2 partially restores the arrest response of Trp53tm1Wahl; p21 protein levels are increased slightly more compared to homozygous Trp53tm1Wahl, Mdm2tm1Glo/+ or homozygous Trp53tm1Wahl, Mdm4/+ heterozygotes




Genotype
MGI:3850703
cx13
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Mdm4tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are present at weaning
• fewer than expected mice are born

hematopoietic system
• mice exhibit decreased extramedullary hematopoiesis in the liver
• at birth

nervous system
• the granule layer of the cerebellum is hypoplastic with defects in both the external granule layer and the internal granule layer
• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

growth/size/body
• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails
• mid-gestation
• mice are smaller than normal at birth

cellular
• following transformation with c-myc and activated Ras oncogenes, mouse embryonic fibroblasts exhibit fewer foci compared with wild-type or single heterozygote cells

renal/urinary system
• fewer and smaller

craniofacial
• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

limbs/digits/tail
• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

immune system

embryo
• mid-gestation

digestive/alimentary system
• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

integument
• embryos are pale mid-gestation

endocrine/exocrine glands




Genotype
MGI:5140383
cx14
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Mdm4tm2.1Glo/Mdm4+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Mdm4tm2.1Glo mutation (0 available); any Mdm4 mutation (191 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• starting in early postnatal development

integument
• starting in early postnatal development

limbs/digits/tail
• starting in early postnatal development




Genotype
MGI:3850681
cx15
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Mdm4tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born in expected Mendelian ratios

hematopoietic system
• bone marrow sections show hypocellularity indicative of aplastic anemia
• bone marrow sections show hypocellularity indicative of aplastic anemia

nervous system
• distribution of Purkinje neurons is disorganized in the cerebellum

pigmentation
• detectable first at P4

integument
• detectable first at P4

limbs/digits/tail
• detectable first at P4




Genotype
MGI:3625179
cx16
Allelic
Composition
Mdm2tm1Glo/Mdm2+
Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (53 available)
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• presence of one copy of Mdm2 partially restores the arrest response of Trp53tm1Wahl; p21 protein levels are modestly increased from homozygous Trp53 mutant levels




Genotype
MGI:5140361
cx17
Allelic
Composition
Mdm2tm1Bay/Mdm2+
Rpl27aSfa/Rpl27a+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Bay mutation (1 available); any Mdm2 mutation (53 available)
Rpl27aSfa mutation (0 available); any Rpl27a mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging





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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory