All Phenotypes Egfr<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Egfr⁺
wild type
MGI:2178395

Summary

18 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Egfr^Mhdadsk5/Egfr⁺	C3HeB/FeJ-Egfr^Mhdadsk5/Ieg	MGI:2682259
ht2	Egfr^{tm1a(EUCOMM)Wtsi}/Egfr⁺	C57BL/6N-Egfr^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5781614
ht3	Egfr^Mhdadsk5/Egfr⁺	involves: 129S1/SvImJ * C3HeB/FeJ	MGI:6403356
ht4	Egfr^Wa5/Egfr⁺	involves: BALB/cAnN * C3H/HeN	MGI:2686884
ht5	Egfr^Wa5/Egfr⁺	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623311
ht6	Egfr^Vel/Egfr⁺	involves: C57BL/6J	MGI:3037922
cn7	Chuk^tm1Yhu/Chuk^tm1Yhu Egfr^tm1Mag/Egfr⁺ Tg(KRT5-cre)5132Jlj/0	involves: 129 * C57BL/6 * CD-1	MGI:3817623
cx8	Egfr^Wa5/Egfr⁺ Tgfa^tm1Unc/Tgfa^tm1Unc	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623314
cx9	Egfr^wa2/Egfr⁺ Errfi1^tm1Kln/Errfi1^tm1Kln	involves: 129P2/OlaHsd * C3H/HeSnJ * C57BL/6	MGI:3639757
cx10	Egfr^wa2/Egfr⁺ Fos^{tm2(Fosl1)Wag}/Fos^{tm2(Fosl1)Wag} Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5142271
cx11	Egfr^wa2/Egfr⁺ Fos^tm4.1Wag/Fos^tm4.1Wag Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5142272
cx12	Egfr^wa2/Egfr⁺ Fos^tm3.1Wag/Fos^tm3.1Wag Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:5142269
cx13	Egfr^wa2/Egfr⁺ Fos^tm5.1Wag/Fos^tm5.1Wag Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:5142267
cx14	Egfr^wa2/Egfr⁺ Fos^tm6.1Wag/Fos^tm6.1Wag Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:5142268
cx15	Egfr^wa2/Egfr⁺ Nf1^tm1Fcr/Nf1⁺ Trp53^tm1Brd/Trp53⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * C57BL/6JEi * C3H/HeSnJ	MGI:5485354
cx16	Egfr^wa2/Egfr⁺ Rps6ka3^tm1.1Kry/Y Tg(KRT5-SOS1)892A6Wag/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:5142270
cx17	Apc^Min/Apc⁺ Egfr^Wa5/Egfr⁺	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623317
cx18	Egfr^wa2/Egfr⁺ Tg(KRT5-SOS1)892A6Wag/0	involves: C57BL/6 * CBA	MGI:5142266

Allelic Composition	Egfr^Mhdadsk5/Egfr⁺
Genetic Background	C3HeB/FeJ-Egfr^Mhdadsk5/Ieg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Mhdadsk5 mutation (0 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal skin pigmentation ( J:81301 )

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

limbs/digits/tail

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

integument

waved hair ( J:81301 )

• slight wave to the coat becomes less apparent with age

abnormal nail morphology ( J:81301 )

• increased nail length seen in some mice

thick epidermis ( J:81301 )

• histologically determined

abnormal skin pigmentation ( J:81301 )

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color; evident only in adulthood

• pigmentation defects restricted to the footpads

Allelic Composition	Egfr^{tm1a(EUCOMM)Wtsi}/Egfr⁺
Genetic Background	C57BL/6N-Egfr^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0454_5_C09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Egfr mutation (87 available)

Data Sources

IMPC Data for Egfr

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased leukocyte cell number ( J:175295 )

IMPC - WTSI

immune system

decreased leukocyte cell number ( J:175295 )

IMPC - WTSI

Allelic Composition	Egfr^Mhdadsk5/Egfr⁺
Genetic Background	involves: 129S1/SvImJ * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Mhdadsk5 mutation (0 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to Coronaviridae infection ( J:243599 )

• mice infected with a mouse adapted (MA15) version of severe acute respiratory syndrome coronavirus (SARS-CoV) show enhanced lung damage compared to wild-type mice, showing increased perivascular inflammation with interstitial edema, and alveolar and interstitial spaces filled with proteinaceous fluid and inflammatory cells, however they show a similar weight loss, viral titer, and recovery as wild-type control mice

• aged mice (20-24 weeks old) show increased susceptibility to SARS-CoV infection compared to older wild-type mice, showing higher levels of lung damage, increased edema, perivascular cuffing, interstitial inflammation and cuffing around airways, and enhanced cellular proliferation in lungs

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:243599 )

• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:243599 )

• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:243599

Allelic Composition	Egfr^Wa5/Egfr⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:75964 )

cornea scarring ( J:75964 )

• damage from the open eyelids in the form of corneal scarring is dependent on environment, where mice raised in a pathogen free environment have no apparent defects in eye development

eyelids open at birth ( J:75964 )

• apart from the open eyelids, the eyes of neonates appear normal

integument

abnormal hair texture ( J:75964 )

waved hair ( J:75964 )

• the first coat is described as wavy and subsequent coats are scruffy in appearance

abnormal vibrissa morphology ( J:75964 )

curly vibrissae ( J:75964 )

Allelic Composition	Egfr^Wa5/Egfr⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histological placentae analysis of the Egfr^Wa5/Egfr^Wa5 and Egfr^Wa5/⁺ mice

embryo

abnormal placenta morphology ( J:92308 )

• mildly abnormal placentas

decreased spongiotrophoblast size ( J:92308 )

• reduced spongiotrophoblast at E12.5

abnormal placenta labyrinth morphology ( J:92308 )

• variably compromised labyrinthine layer

• multinucleated labyrinthine trophoblasts

Allelic Composition	Egfr^Vel/Egfr⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Vel mutation (1 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cornea opacity ( J:88776 )

• the eyes of adult heterozygotes exhibit corneal opacity

microphthalmia ( J:88776 )

• the eyes of adult heterozygotes are often small

abnormal eyelid morphology ( J:88776 )

• excessive secretions are always observed at the edges of adult heterozygous mutant eyelids, possibly due to infection, drying, or trauma

abnormal eyelid development ( J:88776 )

• migration of eyelid epithelial cells appears to be defective

failure of eyelid fusion ( J:88776 )

• at E16.5, the upper and lower eyelids of wild-type embryos are fused in the midline, whereas those of heterozygous mutant embryos remain far apart due to defective migration of eyelid epithelial cells

eyelids open at birth ( J:88776 )

• heterozygotes are born with eyelids open, whereas the eyelids of wild-type littermates remain closed until 12 days after birth

cellular

decreased fibroblast cell migration ( J:88776 )

• in vitro, mouse embryonic fibroblasts (MEFs) isolated from heterozygous embryos show ~47% reduction in their migratory ability relative to wild-type MEFs

growth/size/body

weight loss ( J:166602 )

• significant weight loss is observed with addition of 2% dextran sodium sulfate (DSS) to water, suggesting susceptibility to induced colitis

integument

plush coat ( J:88776 )

• coats have a velvet-like texture

waved hair ( J:88776 )

• the first coat is wavy

abnormal hair follicle orientation ( J:88776 )

• after the first coat, pelage hair loses its waviness and appears disoriented, with individual shafts projecting in different directions

curly vibrissae ( J:88776 )

• heterozygotes are born with curly vibrissae

Allelic Composition	Chuk^tm1Yhu/Chuk^tm1Yhu Egfr^tm1Mag/Egfr⁺ Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129 * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Yhu mutation (0 available); any Chuk mutation (51 available)
Egfr^tm1Mag mutation (1 available); any Egfr mutation (87 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:141162 )

• most mice die but some survive

premature death ( J:141162 )

• most mice die but some survive

vision/eye

abnormal eye morphology ( J:141162 )

• mice exhibit eye defects

integument

abnormal coat/ hair morphology ( J:141162 )

• mice exhibit hair defects

thick epidermis ( J:141162 )

• slightly

Allelic Composition	Egfr^Wa5/Egfr⁺ Tgfa^tm1Unc/Tgfa^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (87 available)
Tgfa^tm1Unc mutation (3 available); any Tgfa mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Phenotypes of Egfr^wa2/Egfr^Wa5 and Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ mice

growth/size/body

postnatal growth retardation ( J:92308 )

• reduced postnatal growth although size at birth is normal

• noticeably reduced in size by 1 week of age

• 25% reduction in body size in mice surviving to 6 weeks of age

craniofacial

small mandible ( J:92308 )

• smaller lower jaw

skeleton

small mandible ( J:92308 )

• smaller lower jaw

Allelic Composition	Egfr^wa2/Egfr⁺ Errfi1^tm1Kln/Errfi1^tm1Kln
Genetic Background	involves: 129P2/OlaHsd * C3H/HeSnJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Errfi1^tm1Kln mutation (0 available); any Errfi1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:109556 )

• mice display similar epidermal thickening, suprabasal proliferation and impaired differentiation as Errfi1^tm1Kln homozygotes

Allelic Composition	Egfr^wa2/Egfr⁺ Fos^{tm2(Fosl1)Wag}/Fos^{tm2(Fosl1)Wag} Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Fos^{tm2(Fosl1)Wag} mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:175064 )

decreased tumor growth/size ( J:175064 )

• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument

increased skin papilloma incidence ( J:175064 )

Allelic Composition	Egfr^wa2/Egfr⁺ Fos^tm4.1Wag/Fos^tm4.1Wag Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Fos^tm4.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:175064 )

• mice exhibit the same tumor burden as Tg(KRT5-SOS1)892A6Mka mice

integument

increased skin papilloma incidence ( J:175064 )

• mice exhibit the same tumor burden as Tg(KRT5-SOS1)892A6Mka mice

Allelic Composition	Egfr^wa2/Egfr⁺ Fos^tm3.1Wag/Fos^tm3.1Wag Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Fos^tm3.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:175064 )

decreased tumor growth/size ( J:175064 )

• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument

increased skin papilloma incidence ( J:175064 )

Allelic Composition	Egfr^wa2/Egfr⁺ Fos^tm5.1Wag/Fos^tm5.1Wag Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Fos^tm5.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin tumor incidence ( J:175064 )

increased skin papilloma incidence ( J:175064 )

decreased tumor growth/size ( J:175064 )

• at 4 weeks, tumor volume is decreased 50% compared to in Tg(KRT5-SOS1)892A6Mka mice

integument

increased skin tumor incidence ( J:175064 )

increased skin papilloma incidence ( J:175064 )

Allelic Composition	Egfr^wa2/Egfr⁺ Fos^tm6.1Wag/Fos^tm6.1Wag Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Fos^tm6.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:175064 )

• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice

increased tumor growth/size ( J:175064 )

integument

increased skin papilloma incidence ( J:175064 )

• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice

Allelic Composition	Egfr^wa2/Egfr⁺ Nf1^tm1Fcr/Nf1⁺ Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * C57BL/6JEi * C3H/HeSnJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Nf1^tm1Fcr mutation (3 available); any Nf1 mutation (161 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:95933 )

• only 1 of 17 (5.9%) mice develop a tumor, a spindle cell tumor compared to 57.9% of double heterozygous Nf1 and Trp53 mutants; this mouse was sacrificed at 21 weeks of age

Allelic Composition	Egfr^wa2/Egfr⁺ Rps6ka3^tm1.1Kry/Y Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Rps6ka3^tm1.1Kry mutation (0 available); any Rps6ka3 mutation (13 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:175064 )

decreased tumor growth/size ( J:175064 )

• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument

increased skin papilloma incidence ( J:175064 )

Allelic Composition	Apc^Min/Apc⁺ Egfr^Wa5/Egfr⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (156 available)
Egfr^Wa5 mutation (2 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:92308 )

• 46% reduction in the number of macroscopic intestinal polyps in comparison to mice heterozygous only for Apc^Min at 3 months of age

• no reduction in tumor size

Allelic Composition	Egfr^wa2/Egfr⁺ Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (87 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

increased skin tumor incidence ( J:175064 )

increased skin papilloma incidence ( J:175064 )

neoplasm

increased skin tumor incidence ( J:175064 )

increased skin papilloma incidence ( J:175064 )

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