Phenotype Image Detail

Image

Caption

A: Representative Egfr^wa2/Egfr^Wa5 compound mutant mouse (front) with hair loss and eye defects compared with wild type littermate (back). B: Narrow, elongated snout, underdeveloped lower jaw, and loss of whiskers were also observed in Egfr^wa2/Egfr^Wa5 compound mutants. C: Two Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ pups (right) with representative growth retardation compared with four wild type littermates (left). The mice in A and B were 2 months old and in C, 2 weeks old.

This image is from Lee D, Mamm Genome 2004 Jul;15(7):525-36 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:92308

Associated
Alleles

Symbol	Name
Egfr^wa2	epidermal growth factor receptor; waved 2
Egfr^Wa5	epidermal growth factor receptor; waved 5
Tgfa^tm1Unc	transforming growth factor alpha; targeted mutation 1, University of North Carolina

Associated
Genotypes

Allelic Composition	Genetic Background
Egfr^wa2/Egfr^Wa5	involves: BALB/cAnN * C3H/HeN * C57BL/6J
Egfr^Wa5/Egfr⁺ Tgfa^tm1Unc/Tgfa^tm1Unc	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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