Analysis Tools
normal phenotype
|
• no overt phenotype; females do not appear to have a defect in maternal milk production or quality
|
|
Allele Symbol Allele Name Allele ID |
Waptm1(cre)Arge targeted mutation 1, Argiris Efstratiadis MGI:2177210 |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
16 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no overt phenotype; females do not appear to have a defect in maternal milk production or quality
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Histology and immunophenotyping of mammary carcinomas in Eef1a1tm1(Kras*)Arge/Eef1a1+ Waptm1(cre)Arge/Wap+ mice
|
• median tumor-free survival of lactating female mice is 9 days from the first parturition
|
|
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass
|
|
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass
|
|
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:146290 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• median tumor free survival of lactating females is 101 days from the first parturition
|
|
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition
|
|
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition
|
|
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• premature death
|
|
• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)
|
|
• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• median tumor free survival of lactating females is 43 days from the first parturition
|
|
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition
|
|
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition
|
|
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• compared with Brca1tm2.1Cxd/Brca1tm2.1Cxd Trp53tm3Tyj/Trp53tm3Tyj Waptm1(cre)Arge/Waptm1(cre)Arge
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 308 days compared with 380 days in Trp53tm3Tyj Waptm1(cre)Arge double heterozygotes
• however, latency is similar to in Brca1tm2.1Cxd/Brca1tm2.1Cxd Trp53tm3Tyj/Trp53+ Waptm1(cre)Arge/Wap+
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 308 days compared with 380 days in Trp53tm3Tyj Waptm1(cre)Arge double heterozygotes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass
|
|
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass
|
|
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:70564 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass
|
|
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass
|
|
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:70564 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/21/2024 MGI 6.23 |
|
|
|
||