Bard1^tm2Thl
Targeted Allele Detail

Summary

• Symbol: Bard1^tm2Thl
• Name: BRCA1 associated RING domain 1; targeted mutation 2, Thomas Ludwig
• MGI ID: MGI:3790742
• Synonyms: Bard1^flex1
• Gene: Bard1 Location: Chr1:71066690-71142300 bp, - strand Genetic Position: Chr1, 35.67 cM
• Alliance: Bard1^tm2Thl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' neo cassette was inserted upstream of exon 1 and an additional neo cassette was inserted downstream of exon 1. (J:134977)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bard1^tm2Thl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bard1 Mutation: 54 strains or lines available

References

• Original: J:134977 Shakya R, et al., The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5
• All: 1 reference(s)