All Phenotypes Bard1<tm2Thl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bard1^tm2Thl
targeted mutation 2, Thomas Ludwig
MGI:3790742

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bard1^tm2Thl/Bard1^tm2Thl	involves: 129 * C57BL/6J	MGI:3805022
cn2	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129S1/Sv * C57BL/6J	MGI:3805024
cn3	Bard1^tm2Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J	MGI:3805029
cn4	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J	MGI:3805035
cn5	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA	MGI:3805023

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:134977 )

• mice are healthy, fertile, and have a normal lifespan

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (54 available)
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (54 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (54 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (54 available)
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (113 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24