Analysis Tools
normal phenotype
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• mice are healthy, fertile, and have a normal lifespan
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Allele Symbol Allele Name Allele ID |
Bard1tm2Thl targeted mutation 2, Thomas Ludwig MGI:3790742 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are healthy, fertile, and have a normal lifespan
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
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|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
|
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:134977 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lethality occurs early in embryonic development
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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