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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bak1tm1Thsn
targeted mutation 1, Craig B Thompson
MGI:2159364
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bak1tm1Thsn/Bak1tm1Thsn B6.129-Bak1tm1Thsn MGI:3847903
hm2
 		Bak1tm1Thsn/Bak1tm1Thsn involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2656013
cn3
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3608659
cn4
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3608663
cn5
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Krastm4Tyj/Kras+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5559061
cn6
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(MMTV-cre)#Mam/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB MGI:3819938
cn7
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)548Jxm/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5562713
cn8
 		Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Bak1tm1Thsn/Bak1tm1Thsn
Tg(Lck-cre)1Cwi/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691371
cn9
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691376
cx10
 		Bak1tm1Thsn/Bak1tm1Thsn
Bcl2l1tm1Dlo/Bcl2l1+ 		B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn MGI:3847907
cx11
 		Bak1tm1Thsn/Bak1+
Bcl2l1tm1Dlo/Bcl2l1+ 		B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn MGI:3847904
cx12
 		Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+ 		involves: 129 * BALB/c * C57BL/6 MGI:3847906
cx13
 		Hax1tm1Jni/Hax1tm1Jni
Bak1tm1Thsn/Bak1tm1Thsn 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3777918
cx14
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk 		involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6 MGI:2656014
cx15
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk 		involves: 129S1/Sv * 129X1/SvJ MGI:3819936


Genotype
MGI:3847903
hm1
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Genetic
Background		 B6.129-Bak1tm1Thsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytosis ( J:149205 )
• platelet cell numbers are about 50% higher than controls
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly increased by about 50% compared to controls

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly increased by about 50% compared to controls




Genotype
MGI:2656013
hm2
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:66872 )
• mutants are developmentally normal, exhibit normal fertility and fail to develop any age-related disorders




Genotype
MGI:3608659
cn3
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased pro-B cell number ( J:100463 )
• 4-fold increase in the number of CD43+IgM- Pro-B cells
decreased marginal zone B cell number ( J:100463 )
• relative number of CD21highCD23low marginal zone B cells is decreased
increased B cell number ( J:100463 )
• increase in the number of B cells at all stages of development in the bone marrow and spleen
increased transitional stage B cell number ( J:100463 )
• a 3-5 fold increase in the numbers of transitional B cells
increased B-2 B cell number ( J:100463 )
• an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity
increased follicular B cell number ( J:100463 )
• an increase in CD21intCD23high follicular B cells
increased pre-B cell number ( J:100463 )
• a 4-fold increase in the number of IgM+ immature B cells
abnormal B cell physiology ( J:100463 )
• B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage
• cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA
increased immunoglobulin level ( J:100463 )
• all isotypes were 5-10 times higher than controls
increased IgG level ( J:100463 )
• increased IgG1, IgG2, IgG2b and IgG3

hematopoietic system
increased pro-B cell number ( J:100463 )
• 4-fold increase in the number of CD43+IgM- Pro-B cells
increased bone marrow cell number ( J:100463 )
• 2-fold increase in total cellularity of bone marrow cells, due to accumulation of developing B cells
decreased marginal zone B cell number ( J:100463 )
• relative number of CD21highCD23low marginal zone B cells is decreased
increased B cell number ( J:100463 )
• increase in the number of B cells at all stages of development in the bone marrow and spleen
increased transitional stage B cell number ( J:100463 )
• a 3-5 fold increase in the numbers of transitional B cells
increased B-2 B cell number ( J:100463 )
• an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity
increased follicular B cell number ( J:100463 )
• an increase in CD21intCD23high follicular B cells
increased pre-B cell number ( J:100463 )
• a 4-fold increase in the number of IgM+ immature B cells
abnormal B cell physiology ( J:100463 )
• B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage
• cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA
increased immunoglobulin level ( J:100463 )
• all isotypes were 5-10 times higher than controls
increased IgG level ( J:100463 )
• increased IgG1, IgG2, IgG2b and IgG3




Genotype
MGI:3608663
cn4
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:100463 )
• by 35 weeks after induction of Cre expression (and thus Bax deletion) in the adult, 78% of mutants die compared to 5% of wild-type

immune system
abnormal T cell differentiation ( J:100463 )
• thymic T cell development is perturbed after poly(I:C) injection
increased leukocyte cell number ( J:100463 )
• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult
increased B cell number ( J:100463 )
• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression
increased susceptibility to autoimmune disorder ( J:100463 )
• develop autoimmune disease after poly(I:C) injection to induce Bax deletion in the adult
increased anti-double stranded DNA antibody level ( J:100463 )
• show elevated serum antinuclear antibodies and anti-dsDNA antibody after 30 weeks of poly(I:C) injection to induce Bax deletion in the adult
autoimmune arthritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult
glomerulonephritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult

hematopoietic system
abnormal T cell differentiation ( J:100463 )
• thymic T cell development is perturbed after poly(I:C) injection
increased leukocyte cell number ( J:100463 )
• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult
increased B cell number ( J:100463 )
• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression

renal/urinary system
glomerulonephritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult

skeleton
autoimmune arthritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult




Genotype
MGI:5559061
cn5
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased adenocarcinoma incidence ( J:125101 )
• intranasal instillation of an adenovirus expressing Cre recombinase (Ad-Cre) results in the development of sinonasal adenocarcinomas
• however, mice injected intramuscularly with Ad-Cre into the extremities or uterus do not develop soft tissue sarcomas




Genotype
MGI:3819938
cn6
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (108 available)
Tg(MMTV-cre)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:141545 )
N
• unlike in Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam Tg(MMTV-cre)Mam mice or Bnip3ltm1Ney homozygotes, spleen size, red blood cell numbers and reticulocytes clear of mitochondria are normal




Genotype
MGI:5562713
cn7
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased regulatory T cell number ( J:208318 )
• at 15 months as in Bcl2l11tm1.1Ast homozygotes

hematopoietic system
increased regulatory T cell number ( J:208318 )
• at 15 months as in Bcl2l11tm1.1Ast homozygotes




Genotype
MGI:5691371
cn8
Allelic
Composition		 Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Bak1tm1Thsn/Bak1tm1Thsn
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2tm1.1Ehyc mutation (0 available); any Vdac2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:220951 )
N
• thymus size normal
• thymocyte number normal
• no increase in apoptosis




Genotype
MGI:5691376
cn9
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:220951 )
• completely resistant to apoptosis

cellular
decreased thymocyte apoptosis ( J:220951 )
• completely resistant to apoptosis

hematopoietic system
decreased thymocyte apoptosis ( J:220951 )
• completely resistant to apoptosis

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:220951 )
• completely resistant to apoptosis




Genotype
MGI:3847907
cx10
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Bcl2l1tm1Dlo/Bcl2l1+
Genetic
Background		 B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (108 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytosis ( J:149205 )
• platelet cell numbers are about 50% higher than controls
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly increased by about 50% compared to controls

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly increased by about 50% compared to controls




Genotype
MGI:3847904
cx11
Allelic
Composition		 Bak1tm1Thsn/Bak1+
Bcl2l1tm1Dlo/Bcl2l1+
Genetic
Background		 B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (108 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet morphology ( J:149205 )
• the low platelet numbers of Bcl2l1tm1Dlo heterozygotes do not occur in these mice




Genotype
MGI:3847906
cx12
Allelic
Composition		 Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (108 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet morphology ( J:149205 )
• the low platelet numbers of Bcl2l1Plt20 heterozygotes do not occur in these mice




Genotype
MGI:3777918
cx13
Allelic
Composition		 Hax1tm1Jni/Hax1tm1Jni
Bak1tm1Thsn/Bak1tm1Thsn
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Hax1tm1Jni mutation (0 available); any Hax1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:132627 )
• survival reduced relative to controls but improved relative to Hax1tm1Jni single homozygous mice




Genotype
MGI:2656014
cx14
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:66872 )
• majority die within 48 hours of birth, although some survive to adulthood

limbs/digits/tail
interdigital webbing ( J:66872 )
• mutants retain interdigital webs on both fore and rear paws

reproductive system
vagina atresia ( J:66872 )
• seen in all adult females

behavior/neurological
circling ( J:66872 )
• display circling behavior when exposed to external stress
seizures ( J:66872 )
• stress-induced seizure activity

hearing/vestibular/ear
abnormal hearing physiology ( J:66872 )
• unresponsive to auditory stimuli

hematopoietic system
abnormal definitive hematopoiesis ( J:66872 )
• hematopoietic colony assays show an increase in the number of myeloid colony forming units and a mild increase in erythroid and megakaryocyte colony forming units
anemia ( J:66872 )
• mild anemia
increased lymphocyte cell number ( J:66872 )
• increases within the circulation and the peripheral lymphoid organs
• lymphocytic infiltration is seen in parenchymal organs, liver, and kidney
abnormal B cell morphology ( J:66872 )
• B220+ B cells present in the lymph node and spleen are skewed toward a B220brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells
abnormal T cell morphology ( J:66872 )
• T cells that accumulate in mutants are skewed toward a memory cell phenotype
increased spleen red pulp amount ( J:66872 )
• expanded red pulp contains a large increase in the number of plasma cells and histiocytes
increased spleen white pulp amount ( J:66872 )
• pronounced hyperplasia
abnormal splenocyte physiology ( J:66872 )
• isolated splenocytes cultured in suspension show enhanced survival

immune system
increased lymphocyte cell number ( J:66872 )
• increases within the circulation and the peripheral lymphoid organs
• lymphocytic infiltration is seen in parenchymal organs, liver, and kidney
abnormal B cell morphology ( J:66872 )
• B220+ B cells present in the lymph node and spleen are skewed toward a B220brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells
abnormal T cell morphology ( J:66872 )
• T cells that accumulate in mutants are skewed toward a memory cell phenotype
increased spleen red pulp amount ( J:66872 )
• expanded red pulp contains a large increase in the number of plasma cells and histiocytes
increased spleen white pulp amount ( J:66872 )
• pronounced hyperplasia
abnormal splenocyte physiology ( J:66872 )
• isolated splenocytes cultured in suspension show enhanced survival

nervous system
seizures ( J:66872 )
• stress-induced seizure activity
abnormal brain morphology ( J:66872 )
• increase in the number of neurons in multiple regions of the brain
• large accumulation of small neuronal cells (neural stem cells) with dense chromatin staining in the periventricular region
increased neuron number ( J:66872 )
• in multiple regions of the brain

cellular
decreased cellular sensitivity to gamma-irradiation ( J:66872 )
• thymocytes show enhanced survival compared to wild-type when exposed to gamma irradiation

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:66872 )
• thymocytes are resistant to treatment with etoposide, a chemotherapeutic agent that normally induces cell death

growth/size/body
enlarged spleen ( J:66872 )




Genotype
MGI:3819936
cx15
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:141545 )
N
• unlike in Bnip3ltm1Ney homozygotes, reticulocytes clearance of mitochondria is normal




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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory