All Phenotypes Lmx1b<tm1Rjo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmx1b^tm1Rjo
targeted mutation 1, Randy L Johnson
MGI:2158463

Summary

18 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129 * C57BL/6	MGI:2677374
hm2	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129S7/SvEvBrd	MGI:3052222
hm3	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129S7/SvEvBrd * C57BL/6	MGI:3716366
hm4	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5287987
hm5	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: C57BL/6	MGI:2677677
hm6	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	Not Specified	MGI:2677679
cn7	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo Pitx2^tm4(cre)Jfm/Pitx2⁺	involves: 129S7/SvEvBrd	MGI:4818572
cn8	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Sox9^tm3(cre)Crm/Sox9⁺	involves: 129S7/SvEvBrd	MGI:4441202
cn9	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	MGI:4359810
cn10	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	MGI:4359811
cn11	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3697386
cn12	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:4818573
cn13	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J	MGI:4818571
cn14	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Prrx1-cre)1Cjt/0	involves: 129S7/SvEvBrd * C57BL/6J * SJL/J	MGI:4441203
cx15	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	MGI:4359809
cx16	Lmx1a^tm1Ics/Lmx1a^tm1Ics Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5287988
cx17	Lmx1a^tm1Ics/Lmx1a⁺ Lmx1b^tm1Rjo/Lmx1b⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5287989
cx18	Lmx1a^tm1Ics/Lmx1a^tm1Ics Lmx1b^tm1Rjo/Lmx1b⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5287990

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lmx1b^tm1Rjo/Lmx1b^tm1Rjo newborns display multiple abnormalities in ocular tissues

mortality/aging

neonatal lethality, complete penetrance ( J:47316 )

• all dead within 24 hours after birth

behavior/neurological

abnormal suckling behavior ( J:47316 )

• failure to suckle

craniofacial

abnormal cranial suture morphology ( J:48536 )

• no indication of divisions (sutures) between calvarial bones in newborns

abnormal fontanelle morphology ( J:48536 )

• in newborn mice, fontanelles absent at midline intersection of frontal and parietal ossification centers and parietal and interparietal bones

abnormal interparietal bone morphology ( J:48536 )

• undeveloped and abnormally fused to parietal bone

absent supraoccipital bone ( J:48536 )

embryo

abnormal developmental patterning ( J:47316 )

• of the limbs and feet, dorsal-ventral patterning is lost

limbs/digits/tail

absent ulna ( J:47316 )

absent patella ( J:47316 )

renal/urinary system

abnormal renal glomerulus basement membrane morphology ( J:47316 )

• thickened basement membrane, with occasional areas of discontinuity

increased renal glomerulus basement membrane thickness ( J:47316 )

skeleton

abnormal cranial suture morphology ( J:48536 )

• no indication of divisions (sutures) between calvarial bones in newborns

abnormal fontanelle morphology ( J:48536 )

• in newborn mice, fontanelles absent at midline intersection of frontal and parietal ossification centers and parietal and interparietal bones

abnormal interparietal bone morphology ( J:48536 )

• undeveloped and abnormally fused to parietal bone

absent supraoccipital bone ( J:48536 )

absent ulna ( J:47316 )

absent patella ( J:47316 )

abnormal pectoral girdle bone morphology ( J:47316 )

abnormal clavicle morphology ( J:47316 )

• abnormally bent, projecting along surface of scapula, rather than away from it

small scapula ( J:47316 )

• smaller than wild-type controls

absent ilium ( J:47316 )

abnormal cartilage development ( J:48536 )

• reductions in size of cartilaginous precursors of calvarial bones

vision/eye

abnormal anterior eye segment morphology ( J:60307 )

abnormal ciliary body morphology ( J:60307 )

• lacked ciliary folds

• stromal hypoplasia

abnormal iris stroma morphology ( J:60307 )

• hypoplastic

irregularly shaped pupil ( J:60307 )

abnormal corneal stroma morphology ( J:60307 )

• less compact than normal

• ectopic blood vessels evident

decreased eye anterior chamber depth ( J:60307 )

• reduction in anterior chamber depth

abnormal lens epithelium morphology ( J:60307 )

• epithelial cells lack normal cuboidal morphology

microphthalmia ( J:60307 )

integument

absence of all nails ( J:47316 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nail-patella syndrome		DOID:9467	OMIM:161200	J:47316

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain development ( J:117035 )

decreased rhombomere 1 size ( J:117035 )

• small rhombomere 1 with fewer proliferating cells at E10.5

abnormal midbrain-hindbrain boundary development ( J:117035 )

• slight increase in the number of apoptotic cells at the 7 somite stage and a more significant increase at the 13 somite stage

absent midbrain-hindbrain boundary ( J:117035 )

• at E10.5 and E12.5, the constriction at the midbrain-hindbrain boundary is absent

abnormal tectum morphology ( J:117035 )

abnormal superior colliculus morphology ( J:117035 )

• fused to the cerebellum

decreased superior colliculus size ( J:117035 )

small tectum ( J:117035 )

• at E18.5 and P0

• fewer proliferating cells are found at E10.5

abnormal pretectal region morphology ( J:117035 )

• the pretectal region extends further caudally

abnormal cerebral cortex morphology ( J:117035 )

• the cerebral cortex extend further caudally

abnormal cerebellum morphology ( J:117035 )

• the medial portion is absent and the remainder is fused to the superior colliculus

small cerebellum ( J:117035 )

• at E18.5 and P0

abnormal sensory neuron innervation pattern ( J:95961 )

• impaired development of laminae I and II neurons appears to delay the innervation of primary cutaneous afferents

• at E14.5, Trk+ fibers (nociceptive sensory neurons) have not migrated into the dorsal laminae and by E17.5, fibers have migrated but in a disorganized manner

embryo

decreased rhombomere 1 size ( J:117035 )

• small rhombomere 1 with fewer proliferating cells at E10.5

vision/eye

ciliary body hypoplasia ( J:161793 )

• hypoplastic at E18.5

iris stroma hypoplasia ( J:161793 )

• at E18.5

irregularly shaped pupil ( J:161793 )

• at E18.5

abnormal cornea morphology ( J:161793 )

corneal vascularization ( J:161793 )

• blood vessels are present in the corneal stroma

abnormal corneal stroma morphology ( J:161793 )

• less dense

• blood vessels are present

decreased eye anterior chamber depth ( J:161793 )

• decrease in anterior chamber depth

abnormal lens epithelium morphology ( J:161793 )

• thickened

microphthalmia ( J:161793 )

• at E18.5

cardiovascular system

corneal vascularization ( J:161793 )

• blood vessels are present in the corneal stroma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nail-patella syndrome		DOID:9467	OMIM:161200	J:95961

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:95961 )

• laminar boundaries are impaired

• development of laminae I and II neurons is impaired

• innervation of primary cutaneous afferents is delayed

• migration of TrkA+ fibers is disorganized

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nail-patella syndrome		DOID:9467	OMIM:161200	J:95961

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:175535 )

• size of the dopaminergic neuron progenitor domain is reduced

• remaining progenitors are mainly located in the medially

decreased motor neuron number ( J:175535 )

• almost complete loss of ocular motor neurons at E12.5

decreased neuronal precursor cell number ( J:175535 )

• size of the dopaminergic neuron (DN) progenitor domain is reduced

• remaining DN progenitors are mainly located in the medially

• most DN progenitor cells fail to initiate expression of late DN markers

increased neuron number ( J:175535 )

• increase in the number of red nucleus neurons at E12.5

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Retarded development of the glomerular capillaries in Lmx1b^tm1Rjo/Lmx1b^tm1Rjo mice

renal/urinary system

abnormal podocyte morphology ( J:76088 )

• impaired differentiation

• retained cuboidal shape

absent podocyte foot process ( J:76088 )

• failed to form foot processes

absent podocyte slit diaphragm ( J:76088 )

• failed to form slit diaphragms

abnormal renal glomerulus basement membrane morphology ( J:76088 )

• glomerular basement membrane split

abnormal renal glomerulus morphology ( J:76088 )

• delayed development

• smaller glomerular tuft area than wild-type or heterozygous controls

• capillary network poorly developed

abnormal glomerular capillary morphology ( J:76088 )

• severely retarded outgrowth of glomerular capillaries

abnormal glomerular capillary endothelium morphology ( J:76088 )

• capillary endothelial cells are less fenestrated

absent glomerular endothelium fenestra ( J:76088 )

• reduction or even complete lack of fenestrae in the capillary endothelium

small kidney ( J:76088 )

• smaller than wild-type littermates

cardiovascular system

abnormal glomerular capillary morphology ( J:76088 )

• severely retarded outgrowth of glomerular capillaries

abnormal glomerular capillary endothelium morphology ( J:76088 )

• capillary endothelial cells are less fenestrated

absent glomerular endothelium fenestra ( J:76088 )

• reduction or even complete lack of fenestrae in the capillary endothelium

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Podocyte abnormalities in Lmx1b^tm1Rjo/Lmx1b^tm1Rjo mice

renal/urinary system

abnormal podocyte morphology ( J:76089 )

• impaired differentiation

• retained cuboidal shape

abnormal podocyte foot process morphology ( J:76089 )

• reduced numbers of foot processes

absent podocyte slit diaphragm ( J:76089 )

• fail to form slit diaphragm

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo Pitx2^tm4(cre)Jfm/Pitx2⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm4.1Rjo mutation (1 available); any Lmx1b mutation (16 available)
Pitx2^tm4(cre)Jfm mutation (1 available); any Pitx2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal intraocular muscle morphology ( J:161793 )

• expression analysis indicates the absence of sphincter and dilator muscles in the iris

abnormal iridocorneal angle ( J:161793 )

• angle closure

absent trabecular meshwork ( J:161793 )

absent ciliary body ( J:161793 )

• not detectable

irregularly shaped pupil ( J:161793 )

• at P13

iris hypoplasia ( J:161793 )

abnormal cornea morphology ( J:161793 )

abnormal corneal endothelium morphology ( J:161793 )

• decrease in the amount of corneal endothelial tissue

corneal opacity ( J:161793 )

• at P13

abnormal lens morphology ( J:161793 )

abnormal lens epithelium morphology ( J:161793 )

• thickened

small lens ( J:161793 )

• about 20% smaller relative to overall eye size

microphthalmia ( J:161793 )

• in about 25% of mice at 3 weeks of age

muscle

abnormal intraocular muscle morphology ( J:161793 )

• expression analysis indicates the absence of sphincter and dilator muscles in the iris

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Sox9^tm3(cre)Crm/Sox9⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Sox9^tm3(cre)Crm mutation (1 available); any Sox9 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:158676 )

N	• mice exhibit normal dorsal tendons of the metacarpophalangeal joint

abnormal metacarpal bone morphology ( J:158676 )

• mice exhibit partial duplication of sesamoid bones at the metacarpophalangeal joint compared with wild-type mice

• mice exhibit abnormal tips of the metacarpals

limbs/digits/tail

abnormal metacarpal bone morphology ( J:158676 )

• mice exhibit partial duplication of sesamoid bones at the metacarpophalangeal joint compared with wild-type mice

• mice exhibit abnormal tips of the metacarpals

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0
Genetic Background	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^dr-J mutation (1 available); any Lmx1a mutation (20 available)
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Lmx1a-cre)1Kjmi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal fourth ventricle morphology ( J:152673 )

• fourth ventricle roof plate size is dramatically smaller relative to wild-type or Lmx1a-null mice at E10.5

abnormal cerebellum morphology ( J:152673 )

• P20 mice show severe cerebellar defects

abnormal cerebellum development ( J:152673 )

• at E12.5, reduced proliferation is observed in the cerebellar anlage

small cerebellum ( J:152673 )

• cerebellum is reduced in size

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0
Genetic Background	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:152673 )

N	• rhombomere 1 roofplate is normal

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm1Zfc mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

small tectum ( J:117035 )

• severe reduction in size at P0

small cerebellum ( J:117035 )

• severe reduction in size at P0

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cornea morphology ( J:161793 )

• sparsely distributed corneal keratocytes, disorganized collagen fibrils, and wavy lamellae by 4 weeks after tamoxifen treatment

corneal vascularization ( J:161793 )

• by 4 weeks after tamoxifen treatment

decreased corneal epithelium thickness ( J:161793 )

• thinner by 4 weeks after tamoxifen treatment

corneal opacity ( J:161793 )

• corneas become cloudy by 4 weeks after tamoxifen treatment

renal/urinary system

dilated renal tubule ( J:161793 )

• dilated tubules filled with eosinophilic material are seen after tamoxifen treatment

kidney degeneration ( J:161793 )

• a severe degenerative phenotype with dilated tubules filled with eosinophilic material develops after tamoxifen treatment

kidney failure ( J:161793 )

• develops after tamoxifen treatment

behavior/neurological

lethargy ( J:161793 )

• develops several weeks after tamoxifen treatment

cardiovascular system

corneal vascularization ( J:161793 )

• by 4 weeks after tamoxifen treatment

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm4.1Rjo mutation (1 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

ciliary body hypoplasia ( J:161793 )

• hypoplastic at E18.5

iris stroma hypoplasia ( J:161793 )

• at E18.5

irregularly shaped pupil ( J:161793 )

• at E18.5

• less severe than in Lmxb1^tm1Rjo homozygous mice

abnormal cornea morphology ( J:161793 )

corneal vascularization ( J:161793 )

• blood vessels are present in the corneal stroma

abnormal corneal stroma morphology ( J:161793 )

• blood vessels are present

• less dense

decreased eye anterior chamber depth ( J:161793 )

• decrease in anterior chamber depth

abnormal lens epithelium morphology ( J:161793 )

• thickened

microphthalmia ( J:161793 )

• at E18.5

cardiovascular system

corneal vascularization ( J:161793 )

• blood vessels are present in the corneal stroma

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:158676 )

• mice exhibit dorsal-to-ventral transformation of skeletal tissues compared with wild-type mice

absent patella ( J:158676 )

abnormal metacarpal bone morphology ( J:158676 )

• mice exhibit partial duplication of sesamoid bones at the metacarpophalangeal joint compared with wild-type mice

• mice exhibit dorsal sesamoid bones and dorsal cartilagenious protrusion of the metacarpal unlike in wild-type mice

• mice exhibit reduced tips of the metacarpals compared with wild-type mice

• the scaphoid, falciform, and pisiform are duplicated in a dorsal position unlike in wild-type mice

abnormal tendon morphology ( J:158676 )

• mice exhibit dorsal-to-ventral transformation of tendon tissues compared with wild-type mice

• the dorsal tendon is round unlike in wild-type mice

abnormal joint morphology ( J:158676 )

• the dorsal flexure at the ankle is absent

muscle

abnormal tendon morphology ( J:158676 )

• mice exhibit dorsal-to-ventral transformation of tendon tissues compared with wild-type mice

• the dorsal tendon is round unlike in wild-type mice

limbs/digits/tail

abnormal foot pad morphology ( J:158676 )

• mice exhibit less hair on the dorsal skin of the paw that resembles a footpad unlike in wild-type mice

absent patella ( J:158676 )

abnormal metacarpal bone morphology ( J:158676 )

• mice exhibit partial duplication of sesamoid bones at the metacarpophalangeal joint compared with wild-type mice

• mice exhibit dorsal sesamoid bones and dorsal cartilagenious protrusion of the metacarpal unlike in wild-type mice

• mice exhibit reduced tips of the metacarpals compared with wild-type mice

• the scaphoid, falciform, and pisiform are duplicated in a dorsal position unlike in wild-type mice

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal fourth ventricle morphology ( J:152673 )

• rhombomere 1 roofplate is normal

Allelic Composition	Lmx1a^tm1Ics/Lmx1a^tm1Ics Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^tm1Ics mutation (0 available); any Lmx1a mutation (20 available)
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:175535 )

• die before E13.5

Allelic Composition	Lmx1a^tm1Ics/Lmx1a⁺ Lmx1b^tm1Rjo/Lmx1b⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased dopaminergic neuron number ( J:175535 )

• about a 20 - 25% reduction in the number of Nurr1- and Pitx3-expressing cells at E13.5 compared to wild-type or single heterozygous embryos

Allelic Composition	Lmx1a^tm1Ics/Lmx1a^tm1Ics Lmx1b^tm1Rjo/Lmx1b⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased dopaminergic neuron number ( J:175535 )

• dramatic reduction in the number of dopaminergic neurons at E13.5 compared to embryos homozygous for the Lmx1a allele alone

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