All Phenotypes Insr<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Insr⁺
wild type
MGI:2152796

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Insr^tm1Dac/Insr⁺	B6.129S4-Insr^tm1Dac/J	MGI:6160735
ht2	Insr^tm1Dac/Insr⁺	involves: 129 * C57BL/6J	MGI:3802541
ht3	Insr^Rgsc1777/Insr⁺	involves: C3H * C57BL/6JJcl	MGI:3818851
ht4	Insr^tm1Dac/Insr⁺	involves: C3H/HeH * C57BL/6	MGI:3819944
ht5	Insr^tm1Shs/Insr⁺	involves: C57BL/6CrSlc	MGI:3580371
ht6	Insr^Rgsc824/Insr⁺	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3812548
ht7	Insr^Rgsc294/Insr⁺	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3811870
cn8	Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz Insr^tm1Khn/Insr⁺ Tg(Ckmm-cre)5Khn/0	involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB	MGI:3775313
cx9	Gsk3b^tm1Jrw/Gsk3b⁺ Insr^tm1Dac/Insr⁺	involves: 129 * C57BL/6J	MGI:3802542
cx10	Insr^tm1Dac/Insr⁺ Irs2^tm1Mfw/Irs2^tm1Mfw	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:3653871
cx11	Insr^tm1Dac/Insr⁺ Ppp2r2a^igt10/Ppp2r2a⁺	involves: 129S4/SvJae * C3H/HeH * C57BL/6J	MGI:6160731
cx12	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr⁺	involves: 129S4/SvJae * C57BL/6	MGI:3653869
cx13	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Insr^tm1Dac/Insr⁺	involves: 129S4/SvJae * C57BL/6	MGI:5305588
cx14	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575092
cx15	Insr^tm1Dac/Insr⁺ Sox4^Igt4/Sox4⁺	involves: C3H/HeH * C57BL/6	MGI:3819939

Allelic Composition	Insr^tm1Dac/Insr⁺
Genetic Background	B6.129S4-Insr^tm1Dac/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

homeostasis/metabolism

increased circulating insulin level ( J:246319 )

insulin resistance ( J:246319 )

Allelic Composition	Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:135659 )

• both fasting and fed insulin levels were higher than in wild-type mice

insulin resistance ( J:135659 )

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:135659 )

• increased beta cell mass

Allelic Composition	Insr^Rgsc1777/Insr⁺
Genetic Background	involves: C3H * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^Rgsc1777 mutation (1 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:133634 )

• at 54 weeks of age, the founder mouse had a serum glucose level of 537 mg/dL

• progeny of the founder have hyperglycemia and elevated HbA1c at 30 weeks

increased circulating insulin level ( J:133634 )

• progeny of the founder mouse become hyperinsulinemic

Allelic Composition	Insr^tm1Dac/Insr⁺
Genetic Background	involves: C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased insulin secretion ( J:141688 )

• beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose

homeostasis/metabolism

increased insulin secretion ( J:141688 )

• beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose

increased circulating insulin level ( J:141688 )

• circulating insulin levels are almost 3-fold higher and continue to remain higher than controls during a glucose challenge

Allelic Composition	Insr^tm1Shs/Insr⁺
Genetic Background	involves: C57BL/6CrSlc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Shs mutation (1 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:98723 )

• 4 month old heterozygous females and males survived 33.3% and 18.2% longer, respectively, when exposed to 80% oxygen compared to wild-type mice

• dietary restriction (65% of ad libitum) further increases the survival time of heterozygous males and females kept in 80% oxygen

• when exposed to 80% oxygen survival of ovariectomized heterozygous females is decreased and survival of estradiol (E2) treated heterozygous males is increased compared to untreated sex-matched heterozygotes

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:98723 )

• 4 month old heterozygous females and males began to die around 48 hours (similar to wild-type) after paraquat injection but survived longer overall compared to wild-type

homeostasis/metabolism

hyperglycemia ( J:98723 )

• seen in 6% of heterozygous males but not in females; however, no increase in urinary glucose is seen

increased circulating insulin level ( J:98723 )

• seen in males and females in the fed state

impaired glucose tolerance ( J:98723 )

• moderately impaired in heterozygous males but not in females

• estradiol (E2) treatment improved glucose tolerance in males

increased insulin sensitivity ( J:98723 )

• seen in heterozygous females

insulin resistance ( J:98723 )

• seen in heterozygous males

• estradiol (E2) treatment improved insulin sensitivity

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:98723 )

• 4 month old heterozygous females and males began to die around 48 hours (similar to wild-type) after paraquat injection but survived longer overall compared to wild-type

adipose tissue

decreased total body fat amount ( J:98723 )

• fat mass is decreased by 41.3% and 57.5% in heterozygous females and males, respectively, compared to wild-type mice; however, no difference in food intake is seen

• when food intake is restricted to 65% of ad libitum, heterozygous females and males still have decreased fat mass compared to dietary restricted wild-type mice

liver/biliary system

abnormal liver physiology ( J:98723 )

• manganese superoxide dismutase activity is increased 39.9% and 22.9% in the livers of heterozygous females and males, respectively, compared to wild-type mice

Allelic Composition	Insr^Rgsc824/Insr⁺
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^Rgsc824 mutation (1 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased glycosylated hemoglobin level ( J:133634 )

• at 11 weeks of age, the founder mouse had an HbA1c of 11.5%

homeostasis/metabolism

increased glycosylated hemoglobin level ( J:133634 )

• at 11 weeks of age, the founder mouse had an HbA1c of 11.5%

hyperglycemia ( J:133634 )

• at 11 weeks of age, the founder mouse had a serum glucose level of 428 mg/dL

increased circulating insulin level ( J:133634 )

• heterozygous progeny of the founder mouse are hyperinsulinemic

increased urine glucose level ( J:133634 )

• heterozygous progeny of the founder mouse have glucosuria

renal/urinary system

increased urine glucose level ( J:133634 )

• heterozygous progeny of the founder mouse have glucosuria

Allelic Composition	Insr^Rgsc294/Insr⁺
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^Rgsc294 mutation (1 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:133634 )

• serum glucose = 428 mg/dL at 11 wk

increased circulating insulin level ( J:133634 )

increased urine glucose level ( J:133634 )

renal/urinary system

increased urine glucose level ( J:133634 )

Allelic Composition	Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz Insr^tm1Khn/Insr⁺ Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1.1Mhz mutation (2 available); any Igf1r mutation (86 available)
Insr^tm1Khn mutation (1 available); any Insr mutation (95 available)
Tg(Ckmm-cre)5Khn mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:118987 )

N	• heart function and morphology is normal

growth/size/body

growth/size/body region phenotype ( J:118987 )

N	• mice exhibit normal growth rates

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:118987 )

N	• mice exhibit normal glucose homeostasis

Allelic Composition	Gsk3b^tm1Jrw/Gsk3b⁺ Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3b^tm1Jrw mutation (0 available); any Gsk3b mutation (110 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating glucose level ( J:135659 )

• decreased fasting glucose level relative to those in Insr^tm1Dac heterozygous mice

• the rate of glucose disposal and glucose infusion were increased relative to those in Insr^tm1Dac heterozygous mice

• hepatic glucose production is comparable to that in Insr^tm1Dac heterozygous mice

abnormal circulating insulin level ( J:135659 )

• the serum insulin values were significantly decreased relative to those in Insr^tm1Dac heterozygous mice in both the fasting and the fed state

• the values were significantly elevated relative to that in Gsk3b^tm1Jrw heterozygous mice

improved glucose tolerance ( J:135659 )

• compared to Insr^tm1Dac heterozygous mice

insulin resistance ( J:135659 )

• improved over Insr^tm1Dac heterozygous mice, but still insulin resistant compared to wild-type

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:135659 )

• reduced beta cell mass over Insr^tm1Dac heterozygous mice

Allelic Composition	Insr^tm1Dac/Insr⁺ Irs2^tm1Mfw/Irs2^tm1Mfw
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)
Irs2^tm1Mfw mutation (1 available); any Irs2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:80826 )

homeostasis/metabolism

abnormal glucose homeostasis ( J:80826 )

• diabetic at 6 to 8 weeks of age

endocrine/exocrine glands

absent pancreatic beta cells ( J:80826 )

• undetectable at 8 weeks of age

Allelic Composition	Insr^tm1Dac/Insr⁺ Ppp2r2a^igt10/Ppp2r2a⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)
Ppp2r2a^igt10 mutation (0 available); any Ppp2r2a mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:246319 )

• mice exhibit elevated plasma glucose levels from 18 weeks

increased circulating insulin level ( J:246319 )

• plasma insulin levels are elevated more than in either single heterozygote

impaired glucose tolerance ( J:246319 )

• mice show impaired glucose tolerance at 12 weeks of age

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

insulin resistance ( J:246319 )

renal/urinary system

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

behavior/neurological

polydipsia ( J:246319 )

• mice drink more and produce more urine as glycosuria develops

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:246319

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Whb mutation (0 available); any Foxo1 mutation (34 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:79560 )

N	• normal insulin and glucose levels at both 2 and 6 months • no diabetes

Allelic Composition	Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm2.1Dac mutation (0 available); any Foxo1 mutation (34 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:179687 )

• in fasted and re-fed mice

insulin resistance ( J:179687 )

• slightly impaired hypoglycemic response in an insulin intolerance test

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (86 available)
Insrr^tm1Dac mutation (0 available); any Insrr mutation (64 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice may develop testes, ovotestes, and/or ovaries

• gonad type is suggested by degree of gonadal descent and histological analyses

Allelic Composition	Insr^tm1Dac/Insr⁺ Sox4^Igt4/Sox4⁺
Genetic Background	involves: C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)
Sox4^Igt4 mutation (1 available); any Sox4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:141688 )

• these mice have impaired glucose tolerance with glucose levels significantly higher than controls 60 and 120 minutes after glucose administration

• the glucose levels are higher than in mice carrying the mutant Sox4 allele on a background that is homozygote for the wild-type allele of Insr

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