Insr^tm1Shs
Targeted Allele Detail

Summary

• Symbol: Insr^tm1Shs
• Name: insulin receptor; targeted mutation 1, Takuji Shirasawa
• MGI ID: MGI:3580001
• Synonyms: Ir^P1195L
• Gene: Insr Location: Chr8:3200922-3329649 bp, - strand Genetic Position: Chr8, 1.82 cM
• Alliance: Insr^tm1Shs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98723
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A P1195L mutation was engineered into exon 20 using a knock-in strategy. The vector also contained a floxed neo in intron 20 that was subsequently removed from mutants by crossing with mice expressing Cre recombinase in the germline. (J:98723)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insr Mutation: 94 strains or lines available

References

• Original: J:98723 Baba T, et al., Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice. J Biol Chem. 2005 Apr 22;280(16):16417-26
• All: 4 reference(s)