Analysis Tools
immune system
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• in culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis
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Allele Symbol Allele Name Allele ID |
Il15tm1Imx targeted mutation 1, Immunex Research and Development Corporation MGI:2136897 |
| Summary |
13 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of CD8 single-positive thymocytes is decreased relative to wild-type at 3 weeks of age
• absolute number of CD122hi cells are decreased in number among CD8+ cells at all stages of T cell maturation compared to wild-type
• at mature CD40lo stage, CD122hi CD8 SP T cells are almost undetectable in thymi
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• defects in thymic development of mature CD44hiCD122hiCD8+ T cells are detected
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• in blood, mice exhibit strong reduction in CD8+CD44hiCD122hi T cells and total peripheral CD8+ T cell number is reduced by 40-50% compared to wild-type
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• number of CD8 single-positive thymocytes is decreased relative to wild-type at 3 weeks of age
• absolute number of CD122hi cells are decreased in number among CD8+ cells at all stages of T cell maturation compared to wild-type
• at mature CD40lo stage, CD122hi CD8 SP T cells are almost undetectable in thymi
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• defects in thymic development of mature CD44hiCD122hiCD8+ T cells are detected
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• in blood, mice exhibit strong reduction in CD8+CD44hiCD122hi T cells and total peripheral CD8+ T cell number is reduced by 40-50% compared to wild-type
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• number of CD8 single-positive thymocytes is decreased relative to wild-type at 3 weeks of age
• absolute number of CD122hi cells are decreased in number among CD8+ cells at all stages of T cell maturation compared to wild-type
• at mature CD40lo stage, CD122hi CD8 SP T cells are almost undetectable in thymi
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• improved survival after infection with Listeria monocytogenes
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• very susceptible to HSV-2 infection
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• dead by day 9 after Vaccinia infection
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• lower numbers of splenic dendritc cells after Plasmodium chabaudi infection
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• Intestinal intraepithelial lymphocytes maturing outside of the thymus are greatly reduced in numbers
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• reduced numbers of natural killer cells in thymus, liver and spleen
(J:60915)
• NK cell numbers in the intestine are reduced by 100-fold
(J:142654)
• however, the Ncr(NKp46)+CD127+ NK1.1- subset of intestinal natural killer cells is unaffected
(J:142654)
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• absent in uterus
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• two fold reduction in numbers of CD8 single positive cells in spleen and lymph nodes
(J:60915)
• there is a 2-fold loss in total CD8+ T cell numbers and a 3-fold reduction in numbers of CD8+CD44hi T cells
(J:113408)
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• marked reduction
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• by 12 months
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• periferal lymph nodes significantly lower in weight
• decreased cellularity
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• lower levels of malaria specific antibodies produced
• lower levels of total immune globulin
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• decreased levels of IgG1, IgG2a, IgG2b, and IgG3 after Plasmodium infection
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• after plasmodium infection
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• significantly reduced cytolytic activity
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• CD8+ T cell proliferation in vitro is not enhanced in the presence of IL-21 in the same manner as wild-type CD8+ T cells
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• no contact hypersensitivity
• T mediated effects delayed but not B cell activation or antibody production
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• reduced production of IFN gamma by NK cells
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• reduced Il12 production by dendritic cells after Plasmodium infection
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• improved survival after infection with Listeria monocytogenes
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• very susceptible to HSV-2 infection
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• dead by day 9 after Vaccinia infection
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• parasitemia higher but only minor effect on mortality
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• absent in uterus
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• marked acellularity of decidua relative to controls
• thickened decidual arteries at days 12 and 14 of pregnancy
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• thickened decidual arteries at days 12 and 14 of pregnancy
• decidual artery walls thickened and lumen narrowed
• first evidence of abnormality at day 10 of pregnancy and worsening with time
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• slight but significant reduction in weight at birth
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• lower numbers of splenic dendritc cells after Plasmodium chabaudi infection
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• Intestinal intraepithelial lymphocytes maturing outside of the thymus are greatly reduced in numbers
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• reduced numbers of natural killer cells in thymus, liver and spleen
(J:60915)
• NK cell numbers in the intestine are reduced by 100-fold
(J:142654)
• however, the Ncr(NKp46)+CD127+ NK1.1- subset of intestinal natural killer cells is unaffected
(J:142654)
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• absent in uterus
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• two fold reduction in numbers of CD8 single positive cells in spleen and lymph nodes
(J:60915)
• there is a 2-fold loss in total CD8+ T cell numbers and a 3-fold reduction in numbers of CD8+CD44hi T cells
(J:113408)
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• marked reduction
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• by 12 months
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• lower levels of malaria specific antibodies produced
• lower levels of total immune globulin
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• decreased levels of IgG1, IgG2a, IgG2b, and IgG3 after Plasmodium infection
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• after plasmodium infection
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• significantly reduced cytolytic activity
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• CD8+ T cell proliferation in vitro is not enhanced in the presence of IL-21 in the same manner as wild-type CD8+ T cells
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• absent in uterus
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• marked acellularity of decidua relative to controls
• thickened decidual arteries at days 12 and 14 of pregnancy
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• absent in uterus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males also homozygous for this null allele of beta-2 microglobulin die much earlier, with a mean survival of only approximately 20 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• glomerular deposition of IgG at 14 weeks of age is more severe than that of BXSB/MpJ males
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• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
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• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
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• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
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• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males homozygous for both null alleles die earlier than those with just one null allele and with a survival curve essentially the same as that of beta 2 microglobulin null Yaa carrying males, with a mean survival of only 18 weeks
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• elevated over BXSB/MpJ males at 6 and 14 weeks of age
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• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
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• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
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• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
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• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the altered CD8+ T cell development that generates a large proportion of memory T cells in homozygote Itktm1Ljb thymus does not occur in these mice
• there is a 23-fold reduction in peripheral CD8+ T cells compared to wild-type mice and a 7-fold reduction compared to IL-15-sufficient Itktm1Ljb homozygotes
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• the altered CD8+ T cell development that generates a large proportion of memory T cells in homozygote Itktm1Ljb thymus does not occur in these mice
• there is a 23-fold reduction in peripheral CD8+ T cells compared to wild-type mice and a 7-fold reduction compared to IL-15-sufficient Itktm1Ljb homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the number of CD8+ CD44high memory T cells is decreased compared to in wild-type mice or single heterogyzotes
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• the number of CD8+ CD44high memory T cells is decreased compared to in wild-type mice or single heterogyzotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit the same reduction in CD8+ CD44high memory T cells as in Il15tm1Imx Myctm1Atp heterozygotes
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• mice exhibit the same reduction in CD8+ CD44high memory T cells as in Il15tm1Imx Myctm1Atp heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of CD24int CD8 SP thymocytes is less than that seen in Il15-null thymi at 3 weeks of age
• absolute number of CD122hi cells is reduced in number among CD8+ T cells at all stages of T cell development compared to Itk-single null thymi
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• number of CD24int CD8 SP thymocytes is less than that seen in Il15-null thymi at 3 weeks of age
• absolute number of CD122hi cells is reduced in number among CD8+ T cells at all stages of T cell development compared to Itk-single null thymi
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• number of CD24int CD8 SP thymocytes is less than that seen in Il15-null thymi at 3 weeks of age
• absolute number of CD122hi cells is reduced in number among CD8+ T cells at all stages of T cell development compared to Itk-single null thymi
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 100-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice
• the remaining NK cells have not proliferated within the first 3 days of transfer
• NK cells isolated from Tg(BCL2)25Wehi have a 2.5 fold higher survival rate 5 days after transfer into these recipient mice
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• 100-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice
• the remaining NK cells have not proliferated within the first 3 days of transfer
• NK cells isolated from Tg(BCL2)25Wehi have a 2.5 fold higher survival rate 5 days after transfer into these recipient mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• middle-aged mice exhibit a rescue of regulatory T cells compared with Il15tm1Imx homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Eomes- NK cells are lacking
• Eomes+ NK cells are lacking
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• Eomes- NK cells are lacking
• Eomes+ NK cells are lacking
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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