Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
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immune system
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• neutrophil migration in a chemotaxis assay with fMLP stimulation is reduced compared to for wild-type cells
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• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
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• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
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skeleton
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• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
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cellular
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• neutrophil migration in a chemotaxis assay with fMLP stimulation is reduced compared to for wild-type cells
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hematopoietic system
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• neutrophil migration in a chemotaxis assay with fMLP stimulation is reduced compared to for wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
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cardiovascular system
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• exhibit increased fractional shortening, velocity of circumferential fiber shortening, and peak aortic outflow velocity, indicating enhanced contractility
• individual cardiomyocytes display an increase in contractility
• treatment of cardiomyocytes with a cAMP blocker leads to a greater reduction in contractility compared to wild-type
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• exhibit a significant increase in the rate of relaxation in cardiomyocytes despite the increase in peak contraction
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muscle
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• exhibit increased fractional shortening, velocity of circumferential fiber shortening, and peak aortic outflow velocity, indicating enhanced contractility
• individual cardiomyocytes display an increase in contractility
• treatment of cardiomyocytes with a cAMP blocker leads to a greater reduction in contractility compared to wild-type
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• exhibit a significant increase in the rate of relaxation in cardiomyocytes despite the increase in peak contraction
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
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immune system
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• reduction in thymic cellularity
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• mice have a higher percentage of CD117+ CD27+ NK cells and lower percentages of 2B4+ NK cells than in splenic NK cells from wild-type mice
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• T cell development is altered however B cell development is normal
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• decrease in CD4+CD8- T cells in the spleen
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• thymocytes exhibit an increase in apoptosis compared to wild-type after stimulation with adenosine receptor agonists
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• GRCR-induced respiratory burst is decreased in freshly isolated bone marrow neutrophils
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• 70% decrease in fMLP- and C5a-induced chemotaxis of neutrophils
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• accumulation of neutrophils in the peritoneal cavities is reduced in response to casein-induced peritonitis of Listeria infection
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• lymphocytic choriomeningitis virus (LCMV) induced footpad-swelling is reduced, indicating impaired CD+ T cell-dependent antiviral responses
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• production of antibodies to NIP after NIP-OVA immunization is reduced indicating impairment of functional T helper cell-dependent responses to hapten antigens
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• NK cells are slightly less lytic than wild-type cells
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• T cells exhibit impaired proliferation in response to anti-CD3 epsilon on Con A stimulation, however exhibit normal proliferation in response to PMA/Ca+ inonaphore
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• T cells produce lower amounts of interferon-gamma in response to treatment with anti-CD3 epsilon and anti-CD28, Con A, or PMA/Ca+ ionaphore
(J:60347)
• mice exhibit decreased IFN-gamma secretion following NK1.1 or IL-12/IL-18 stimulation compared to in wild-type mice
(J:124330)
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• T cells produce lower amounts of IL-2 in response to treatment with anti-CD3 epsilon and anti-CD28, Con A, or PMA/Ca+ ionaphore
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hematopoietic system
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• reduction in thymic cellularity
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• increase in total and relative numbers of Gr1+Mac1+ myeloid cells in the spleen but not in bone marrow
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• mice have a higher percentage of CD117+ CD27+ NK cells and lower percentages of 2B4+ NK cells than in splenic NK cells from wild-type mice
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• T cell development is altered however B cell development is normal
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• decrease in CD4+CD8- T cells in the spleen
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• GRCR-induced respiratory burst is decreased in freshly isolated bone marrow neutrophils
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• 70% decrease in fMLP- and C5a-induced chemotaxis of neutrophils
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• accumulation of neutrophils in the peritoneal cavities is reduced in response to casein-induced peritonitis of Listeria infection
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• lymphocytic choriomeningitis virus (LCMV) induced footpad-swelling is reduced, indicating impaired CD+ T cell-dependent antiviral responses
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• production of antibodies to NIP after NIP-OVA immunization is reduced indicating impairment of functional T helper cell-dependent responses to hapten antigens
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• NK cells are slightly less lytic than wild-type cells
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• T cells exhibit impaired proliferation in response to anti-CD3 epsilon on Con A stimulation, however exhibit normal proliferation in response to PMA/Ca+ inonaphore
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cellular
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• 70% decrease in fMLP- and C5a-induced chemotaxis of neutrophils
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• T cells exhibit impaired proliferation in response to anti-CD3 epsilon on Con A stimulation, however exhibit normal proliferation in response to PMA/Ca+ inonaphore
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endocrine/exocrine glands
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• reduction in thymic cellularity
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
Ptentm2Mak mutation
(4 available);
any
Pten mutation
(81 available)
Tg(Ckmm-cre)5Khn mutation
(4 available)
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cardiovascular system
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• significantly enlarged compared to wild-type and single homozygous Pik3cgtm1Pngr mice
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• extent of cardiac hypertrophy is similar to that seen in mice with cardiomyocyte-specific inactivation of Pten
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• hearts are hypercontractile as assessed by increased fractional shortening, velocity or circumferential fiber shortening, and peak aortic outflow velocity
• individual cardiomyocytes display increased contractility despite the hypertrophy
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muscle
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• hearts are hypercontractile as assessed by increased fractional shortening, velocity or circumferential fiber shortening, and peak aortic outflow velocity
• individual cardiomyocytes display increased contractility despite the hypertrophy
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growth/size/body
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• significantly enlarged compared to wild-type and single homozygous Pik3cgtm1Pngr mice
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• extent of cardiac hypertrophy is similar to that seen in mice with cardiomyocyte-specific inactivation of Pten
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
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immune system
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• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
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• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice
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• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice
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• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice
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skeleton
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• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice
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cellular
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• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
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hematopoietic system
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• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
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• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
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immune system
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• corticomedullary differentiation is lost
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• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
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• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression
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• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice
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• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice
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• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells
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hematopoietic system
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• corticomedullary differentiation is lost
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• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
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• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression
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• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice
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• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice
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• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells
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endocrine/exocrine glands
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• corticomedullary differentiation is lost
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• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Jni mutation
(0 available);
any
Pik3cd mutation
(43 available)
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
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immune system
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• mice exhibit a high percentage of CD117+ and CD27+ NK cells and about 40% to 50% immature CD27 CD11b- cells compared to in wild-type mice
• NK cell development is blocked before the stage at which they acquire Ly49 receptors
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• mice exhibit a 60% to 70% reduction in NK cells in the spleen compared to in wild-type mice
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• CD3+ T cell numbers and percentages are reduced compared to in wild-type mice
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• total splenocyte numbers are reduced 50% compared to in wild-type mice
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• NK cells are less lytic than wild-type cells
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• mice exhibit decreased IFN-gamma secretion following NK1.1 or IL-12/IL-18 stimulation compared to in wild-type mice
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hematopoietic system
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• mice exhibit a high percentage of CD117+ and CD27+ NK cells and about 40% to 50% immature CD27 CD11b- cells compared to in wild-type mice
• NK cell development is blocked before the stage at which they acquire Ly49 receptors
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• mice exhibit a 60% to 70% reduction in NK cells in the spleen compared to in wild-type mice
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• CD3+ T cell numbers and percentages are reduced compared to in wild-type mice
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• total splenocyte numbers are reduced 50% compared to in wild-type mice
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• NK cells are less lytic than wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Pngr mutation
(1 available);
any
Ace2 mutation
(54 available)
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
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cardiovascular system
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• increase in basal myocardial contractility
• mice exhibit a partial reversal of myocardial hypertrophy, prevention of neutrophil infiltration into myocardial tissue, and prevention of systolic function deterioration
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muscle
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• increase in basal myocardial contractility
• mice exhibit a partial reversal of myocardial hypertrophy, prevention of neutrophil infiltration into myocardial tissue, and prevention of systolic function deterioration
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Analysis Tools