Pik3cg^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Pik3cg^tm1Pngr
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:1858013
• Synonyms: p110gamma-, PI3Kgamma-
• Gene: Pik3cg Location: Chr12:32223472-32258658 bp, - strand Genetic Position: Chr12, 13.74 cM, cytoband B
• Alliance: Pik3cg^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60347
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 5 kb of this gene (amino acids 1-670) was replaced with a PGK-neo cassette via homologous recombination. Southern and Northern blot was used to confirm the null allele. Protein product was absent in neutrophils, T cells, and thymocytes from homozygous mutant animals as determined by Western blot. (J:60347)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pik3cg^tm1Pngr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cg Mutation: 59 strains or lines available

References

• Original: J:60347 Sasaki T, et al., Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration [see comments]. Science. 2000 Feb 11;287(5455):1040-6
• All: 79 reference(s)