All Phenotypes Dnmt1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnmt1⁺
wild type
MGI:1857561

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dnmt1^em2Jiemw/Dnmt1⁺	C57BL/6-Dnmt1^em2Jiemw	MGI:7506876
ht2	Dnmt1^MommeD2/Dnmt1⁺	FVB/NJ-Dnmt1^MommeD2	MGI:3607156
cn3	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Dnmt1^tm2Jae/Dnmt1⁺ Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5515307
cx4	Dnmt1^tm1Pwl/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3848458
cx5	Dnmt1^tm1Jae/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3848459
cx6	Dnmt1^{tm1(tetO-BCL2)Sjk}/Dnmt1⁺ Tg(IghMyc)22Bri/0 Tg(MMTVtTA)1Mam/0	involves: 129S4/SvJae * C57BL/6	MGI:3511863
cx7	Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1⁺	involves: 129S4/SvJae * C57BL/6J	MGI:3848451
cx8	Apc^Min/Apc⁺ Dnmt1^tm1Pwl/Dnmt1⁺	involves: 129S4/SvJae * C57BL/6J	MGI:3848450
cx9	A^vy/A Dnmt1^MommeD2/Dnmt1⁺	involves: C57BL/6J * FVB/NJ	MGI:3607157

Allelic Composition	Dnmt1^em2Jiemw/Dnmt1⁺
Genetic Background	C57BL/6-Dnmt1^em2Jiemw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^em2Jiemw mutation (0 available); any Dnmt1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired spatial learning ( J:310870 )

• longer latency, fewer number of platform crossings and less time spent in target quadrant in Morris water maze test

• normal swimming speed in Morris water maze test

abnormal spatial reference memory ( J:310870 )

• higher error ratio in radial 8-arm maze test

abnormal spatial working memory ( J:310870 )

• higher error ratio in radial 8-arm maze test

abnormal response to novel object ( J:310870 )

• no difference in time spent with novel object

cellular

increased neuron apoptosis ( J:310870 )

• in hippocampus

nervous system

increased neuron apoptosis ( J:310870 )

• in hippocampus

decreased neuron number ( J:310870 )

• reduced number of immature DCX+ neurons

decreased neuronal stem cell self-renewal ( J:310870 )

• reduced proliferation of adult NSCs

Allelic Composition	Dnmt1^MommeD2/Dnmt1⁺
Genetic Background	FVB/NJ-Dnmt1^MommeD2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^MommeD2 mutation (0 available); any Dnmt1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:99816 )

• about half of heterozygous females from heterozygous intercrosses do not survive to birth

Allelic Composition	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Dnmt1^tm2Jae/Dnmt1⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11a^tm1Pwt mutation (0 available); any Bcl11a mutation (42 available)
Dnmt1^tm2Jae mutation (1 available); any Dnmt1 mutation (113 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:196140 )

• mild

decreased erythrocyte cell number ( J:196140 )

Allelic Composition	Dnmt1^tm1Pwl/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm1Pwl mutation (0 available); any Dnmt1 mutation (113 available)
Mlh1^tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75745 )

• mice exhibit reduced survival compared with wild-type mice

neoplasm

increased intestinal adenocarcinoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors

increased lymphoma incidence ( J:75745 )

• 29% of mice develop lymphomas

• mice develop lymphomas at an earlier age than in Mlh1^tm1Lisk homozygotes

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors

Allelic Composition	Dnmt1^tm1Jae/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm1Jae mutation (2 available); any Dnmt1 mutation (113 available)
Mlh1^tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75745 )

• mice exhibit poorer survival than in Mlh1^tm1Lisk homozygotes

neoplasm

increased intestinal adenocarcinoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

increased lymphoma incidence ( J:75745 )

• 56% of mice develop lymphomas

• mice develop lymphomas at an earlier age than in Mlh1^tm1Lisk homozygotes

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 41% of mice develop intestinal tumors

Allelic Composition	Dnmt1^{tm1(tetO-BCL2)Sjk}/Dnmt1⁺ Tg(IghMyc)22Bri/0 Tg(MMTVtTA)1Mam/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^{tm1(tetO-BCL2)Sjk} mutation (0 available); any Dnmt1 mutation (113 available)
Tg(IghMyc)22Bri mutation (1 available)
Tg(MMTVtTA)1Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:93549 )

• without doxycycline treatment median survival is 82 days, with doxycycline treatment the improves to 145 days

neoplasm

increased leukemia incidence ( J:93549 )

• in the absence of doxycycline, lymphoblastic leukemia is seen by 2 weeks of age

• in 5 - 7 week old triple transgenics with lymphoblastic leukemia doxycycline treatment resulted in normalization of the WBC count and restoration of normal hematopoiesis

increased B cell derived lymphoma incidence ( J:93549 )

• bulky B cell derived lymphomas, similar to those in Tg(IghMyc)22Bri single transgenics, are seen in older triple transgenics after treatment with doxycycline

behavior/neurological

lethargy ( J:93549 )

• transgenics with leukemia are lethargic, doxycycline treatment returns activity levels to normal

hematopoietic system

enlarged spleen ( J:93549 )

• in the absence of doxycycline, mutants develop an enlarged spleen with doxycycline treatment the spleen returns to its normal size

immune system

enlarged spleen ( J:93549 )

• in the absence of doxycycline, mutants develop an enlarged spleen with doxycycline treatment the spleen returns to its normal size

growth/size/body

enlarged spleen ( J:93549 )

• in the absence of doxycycline, mutants develop an enlarged spleen with doxycycline treatment the spleen returns to its normal size

Allelic Composition	Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (156 available)
Dnmt1^tm1Jae mutation (2 available); any Dnmt1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:75230 )

• mice exhibit fewer intestinal polyps compared with Apc^Min heterozygotes

• polyps are smaller than in Apc^Min heterozygotes

Allelic Composition	Apc^Min/Apc⁺ Dnmt1^tm1Pwl/Dnmt1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (156 available)
Dnmt1^tm1Pwl mutation (0 available); any Dnmt1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:75230 )

• mice exhibit fewer intestinal polyps compared with Apc^Min heterozygotes

• polyps are smaller than in Apc^Min heterozygotes

Allelic Composition	A^vy/A Dnmt1^MommeD2/Dnmt1⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (80 available); any a mutation (468 available)
A^vy mutation (4 available); any a mutation (468 available)
Dnmt1^MommeD2 mutation (0 available); any Dnmt1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

integument

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

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