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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt3a+
wild type
MGI:1857486
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Wnt3aem1(IMPC)Ccpcz/Wnt3a+ C57BL/6NCrl-Wnt3aem1(IMPC)Ccpcz/Ccpcz MGI:7768461
cn2
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365612
cn3
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365611
cn4
 		Emx1tm1(cre)Krj/Emx1+
Wnt3atm2Eag/Wnt3a+ 		involves: 129S2/SvPas MGI:3616432
cn5
 		Itgb1tm1Mll/Itgb1tm1Mll
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129X1/SvJ MGI:4947983
cn6
 		Tg(Otx1-cre)1Eag/0
Wnt3atm2Eag/Wnt3a+ 		Not Specified MGI:3616434
cx7
 		Tbx6tm2Pa/Tbx6+
Wnt3atm1Amc/Wnt3a+ 		involves: 129 * 129S1/Sv * 129X1/SvJ * ICR MGI:3804667
cx8
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+ 		involves: 129 * C57BL/6 MGI:5444714
cx9
 		Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+ 		involves: 129 * C57BL/6 MGI:5444713
cx10
 		Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3a+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BR MGI:3604382


Genotype
MGI:7768461
ht1
Allelic
Composition		 Wnt3aem1(IMPC)Ccpcz/Wnt3a+
Genetic
Background		 C57BL/6NCrl-Wnt3aem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt3aem1(IMPC)Ccpcz mutation (1 available); any Wnt3a mutation (29 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:211773 )
IMPC - CCP-IMG

growth/size/body
enlarged heart ( J:211773 )
IMPC - CCP-IMG

hematopoietic system

homeostasis/metabolism

immune system

integument

skeleton
rib fusion ( J:211773 )
IMPC - CCP-IMG
vertebral fusion ( J:211773 )
IMPC - CCP-IMG

vision/eye




Genotype
MGI:4365612
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (47 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0
• nearly all CRc in the hippocampal formation are ablated




Genotype
MGI:4365611
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 35% at P0




Genotype
MGI:3616432
cn4
Allelic
Composition		 Emx1tm1(cre)Krj/Emx1+
Wnt3atm2Eag/Wnt3a+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (31 available)
Wnt3atm2Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:104373 )
• mice die shortly after birth

craniofacial
short mandible ( J:104373 )
• lower jaw is shorter than normal

nervous system
absent Cajal-Retzius cell ( J:104373 )
• at E12.5, the neocortical zone shows a near complete absence of Cajal-Retzius cells
• at !3.5 and 15.5. the band of Cajal-Retzius cells along the marginal zone of the cortex is absent
absent choroid plexus ( J:104373 )
• at E12.5, the choroid plexus is almost completely absent
abnormal cerebral cortex morphology ( J:104373 )
• at E10, the cortical hem is almost completely ablated
• the caudomedial cortex is highly disorganized and shrunken; however, at E18.5, the layers of the rostral cortex are correctly ordered

skeleton
short mandible ( J:104373 )
• lower jaw is shorter than normal

behavior/neurological
abnormal suckling behavior ( J:104373 )
• newborn mice are unable to suckle

growth/size/body
short mandible ( J:104373 )
• lower jaw is shorter than normal




Genotype
MGI:4947983
cn5
Allelic
Composition		 Itgb1tm1Mll/Itgb1tm1Mll
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Mll mutation (1 available); any Itgb1 mutation (58 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:170581 )
N
• at E15.5, mice exhibit normal Caja-Retzius localization and radial glia scaffold




Genotype
MGI:3616434
cn6
Allelic
Composition		 Tg(Otx1-cre)1Eag/0
Wnt3atm2Eag/Wnt3a+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Otx1-cre)1Eag mutation (0 available)
Wnt3atm2Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cortical marginal zone morphology ( J:104373 )
• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced and remaining cells are dispersed
decreased Cajal-Retzius cell number ( J:104373 )
• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced
abnormal cerebral cortex morphology ( J:104373 )
• cortical hem is present, but smaller than normal




Genotype
MGI:3804667
cx7
Allelic
Composition		 Tbx6tm2Pa/Tbx6+
Wnt3atm1Amc/Wnt3a+
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6tm2Pa mutation (1 available); any Tbx6 mutation (19 available)
Wnt3atm1Amc mutation (1 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:137163 )
N
• despite decrease in Wnt3a expression in Tbx6 null mice, no defects in somite formation are detected

cardiovascular system
cardiovascular system phenotype ( J:137163 )
N
• unlike in Tbx6 null mice, the direction of heart looping is similar to controls




Genotype
MGI:5444714
cx8
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (38 available)
Wnt3atm1Amc mutation (1 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 92% of embryos (n=12) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 14% of embryos (n=14)

digestive/alimentary system
cleft palate ( J:189062 )
• in 14% of embryos (n=14)

growth/size/body
cleft palate ( J:189062 )
• in 14% of embryos (n=14)




Genotype
MGI:5444713
cx9
Allelic
Composition		 Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (38 available)
Wnt3atm1Amc mutation (1 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 37% of embryos (n=16) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:3604382
cx10
Allelic
Composition		 Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (94 available)
Wnt3avt mutation (1 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
kinked tail ( J:64989 )
• variable penetrance of tail kinks is seen and the penetrance is increased compared to either single heterozygote




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory