Wnt3a^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt3a^tm1Amc
• Name: wingless-type MMTV integration site family, member 3A; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:1857489
• Synonyms: Wnt-3a-, Wnt3a-, Wnt3a^neo
• Gene: Wnt3a Location: Chr11:59138859-59181578 bp, - strand Genetic Position: Chr11, 37.17 cM
• Alliance: Wnt3a^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16716
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of neomycin selection cassette into exon 3 introduced a stop codon that results in a truncated peptide approximately one-third the normal size. Transcription of the targeted loci was detected in homozygous mutant embryos via in situ hybridization. (J:16716, J:39344)

Expression

In Mice Carrying this Mutation:	163 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt3a Mutation: 25 strains or lines available

References

• Original: J:16716 Takada S, et al., Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994 Jan;8(2):174-89
• All: 34 reference(s)