Del(18Pcdha-Pcdhg)3Tyag
Targeted Allele Detail

Summary

• Symbol: Del(18Pcdha-Pcdhg)3Tyag
• Name: deletion, Chr 18, Takeshi Yagi 3
• MGI ID: MGI:6331347
• Synonyms: Del(18Pcdha-Pcdhg)1Tyag, Del3Tyag, Pcdhabg^del
• Gene: Del(18Pcdha-Pcdhg)3Tyag Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244163
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(18Pcdha-Pcdhg)3Tyag involves 63 genes/genome features (Pcdha, Pcdhb, Pcdhg ...) View all
• Mutation details: This allele follows the meiotic cre-mediated recombination between the Pcdha^tm13Tyag and Pcdhg^tm1.1Tyag alleles. The Pcdha^tm13Tyag allele has a loxP and FRT site flanked neomycin resistance gene cassette followed by a myc-tagged Venus fluorescent protein gene cassette inserted into the 5' end of the first exon, alpha1, of the first gene in the cluster, Pcdha1. The Pcdhg^tm1Tyag allele has an IRES, a lacZ gene cassette and a loxP site inserted into the 3' UTR of the last shared exon, gammaCR3, of the cluster genes. Recombination between the two results in the complete deletion of the Pcdha, Pcdhb and Pcdhg clusters and the Slc25a2 and Taf7 genes located between Pcdhb and Pcdhg, as well as the inserted Venus gene and neo cassette. (J:244163)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(18Pcdha-Pcdhg)3Tyag Mutation: 0 strains or lines available

References

• Original: J:244163 Hasegawa S, et al., Distinct and Cooperative Functions for the Protocadherin-alpha, -beta and -gamma Clusters in Neuronal Survival and Axon Targeting. Front Mol Neurosci. 2016;9:155
• All: 3 reference(s)