Taf7 MGI Mouse Gene Detail - MGI:1346348 - TATA-box binding protein associated factor 7

Taf7 Gene Detail

Symbol

Taf7
Name

TATA-box binding protein associated factor 7
Synonyms

55kDa, Taf2f, TAFII55

Feature Type

protein coding gene
IDs

MGI:1346348
NCBI Gene: 24074
Gene Overview

MyGene.info: TAF7

Sequence Map

Chr18:37640491-37644204 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

3714 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.54 cM
Mapping Data

4 experiments

Human Ortholog

TAF7, TATA-box binding protein associated factor 7

Vertebrate Orthologs

10

Human Ortholog

TAF7, TATA-box binding protein associated factor 7
Orthology source: HomoloGene, HGNC
Synonyms

TAF2F, TAFII55
Links

HGNC:11541

NCBI Gene ID: 6879

neXtProt AC: NX_Q15545

UniProt: Q15545
Chr Location

5q31.3; chr5:141318490-141320784 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 133942
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TAF7
Gene Tree

Taf7

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Phenotype Summary

13 phenotypes from 2 alleles in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

4
Targeted

5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

3 strains or lines available

Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E5.5. Mice homozygous for a conditional allele activated in thymocytes exhibit impaired T cell differentiation.

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All GO Annotations

38
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

32
Tissues

17
cDNA Data

56
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase taf7

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Taf7 interacts with 199 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

28
RefSeq

2
UniProt

3
CCDS

CCDS29189.1
UniGene

236009

			Length	Strain/Species	Flank
genomic	OTTMUSG00000034268	VEGA Gene Model \| MGI Sequence Detail	3714	C57BL/6J	± kb
transcript	OTTMUST00000087081	VEGA \| MGI Sequence Detail	3302	Not Applicable
polypeptide	OTTMUSP00000047218	VEGA \| MGI Sequence Detail	341	Not Applicable

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SNPs within 2kb

47 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000016033 transcription initiation factor TFIID subunit 7

(term hierarchy)
InterPro Domains

IPR006751 TAFII55 protein, conserved region

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All nucleic 57

Genomic 1

cDNA 56

Microarray probesets 5

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MGI:2147246, MGI:2147382

Summaries

All 44

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 6
Earliest

J:56830 Wu SY, et al., Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription. J Biol Chem. 1999 Aug 13;274(33):23480-90
Latest

J:236825 Langer D, et al., Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Nat Commun. 2016 Mar 30;7:11063

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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