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Taf7 Gene Detail
Summary
  • Symbol
    Taf7
  • Name
    TATA-box binding protein associated factor 7
  • Synonyms
    55kDa, Taf2f, TAFII55
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346348
    NCBI Gene: 24074
  • Gene Overview
    MyGene.info: TAF7
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr18:37640491-37644204 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      3714 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.54 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TAF7, TATA-box binding protein associated factor 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TAF7, TATA-box binding protein associated factor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TAF2F, TAFII55
  • Links
    NCBI Gene ID: 6879
    neXtProt AC: NX_Q15545
    UniProt: Q15545

  • Chr Location
    5q31.3; chr5:141318490-141320784 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 133942
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TAF7
  • Gene Tree
    Taf7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E5.5. Mice homozygous for a conditional allele activated in thymocytes exhibit impaired T cell differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    32
  • Tissues
    17
  • cDNA Data
    56
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034268 VEGA Gene Model | MGI Sequence Detail 3714 C57BL/6J ±  kb
    transcript OTTMUST00000087081 VEGA | MGI Sequence Detail 3302 Not Applicable  
    polypeptide OTTMUSP00000047218 VEGA | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      47 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016033 transcription initiation factor TFIID subunit 7
      (term hierarchy)
    • InterPro Domains
      IPR006751 TAFII55 protein, conserved region
      IPR037817 Transcription initiation factor TFIID subunit 7
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 56

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147246, MGI:2147382
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:56830 Wu SY, et al., Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription. J Biol Chem. 1999 Aug 13;274(33):23480-90
    • Latest
      J:245730 Bardot P, et al., The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development. 2017 Oct 15;144(20):3808-3818
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    05/15/2018
    MGI 6.12     		The Jackson Laboratory