Pcdha Complex/Cluster/Region Detail

Summary

• Symbol
  Pcdha
• Name
  protocadherin alpha cluster
• Synonyms
  PCDHA@

• Feature Type
  complex/cluster/region
• IDs
  MGI:3719085
• Cluster Members
  Pcdha1, Pcdha2, Pcdha3 ... (14 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 18, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  24 phenotypes from 11 alleles in 6 genetic backgrounds
  2 phenotypes from multigenic genotypes
  22 phenotype references
  

• All Mutations and Alleles
  50
• Endonuclease-mediated
  4
• Targeted
  38
• Transgenic
  7
• Genomic Mutations
  6 involving Pcdha
• Find Mice (IMSR)
  52 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for an allele that produces only isoform A exhibit enhanced contextual conditioning, spatial working memory and serotonin levels.

Expression

• Assay Results
  126
• Tissues
  109
• cDNA Data
  1
• Literature Summary
  10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Molecular
Reagents

• All nucleic 7

  cDNA 3

  Primer pair 4

References

• Summaries
  All 33

  Developmental Gene Expression 10

  Phenotypes 22
• Earliest
  J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
• Latest
  J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766

Pcdha Cluster contains:

More Data for these features

Member	Feature Type	Location
Pcdha1, protocadherin alpha 1	protein coding gene	Chr18:37063338-37320710 (+)
Pcdha2, protocadherin alpha 2	protein coding gene	Chr18:37072258-37320710 (+)
Pcdha3, protocadherin alpha 3	protein coding gene	Chr18:37079158-37320710 (+)
Pcdha4, protocadherin alpha 4	protein coding gene	Chr18:37085742-37320710 (+)
Pcdha5, protocadherin alpha 5	protein coding gene	Chr18:37093493-37320710 (+)
Pcdha6, protocadherin alpha 6	protein coding gene	Chr18:37100684-37320710 (+)
Pcdha7, protocadherin alpha 7	protein coding gene	Chr18:37106864-37320716 (+)
Pcdha8, protocadherin alpha 8	protein coding gene	Chr18:37125520-37320710 (+)
Pcdha9, protocadherin alpha 9	protein coding gene	Chr18:37130933-37320710 (+)
Pcdha10, protocadherin alpha 10	protein coding gene	Chr18:37138373-37320710 (+)
Pcdha11, protocadherin alpha 11	protein coding gene	Chr18:37143911-37320710 (+)
Pcdha12, protocadherin alpha 12	protein coding gene	Chr18:37153283-37320710 (+)
Pcdhac1, protocadherin alpha subfamily C, 1	protein coding gene	Chr18:37223189-37320710 (+)
Pcdhac2, protocadherin alpha subfamily C, 2	protein coding gene	Chr18:37276731-37320716 (+)